A5069186186- Gut microbiota and health
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Nutritional Studies and Diet
- Bone health and osteoporosis research
- Air Quality and Health Impacts
- Fatty Acid Research and Health
- Biochemical Analysis and Sensing Techniques
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
- Dietary Effects on Health
- Consumer Attitudes and Food Labeling
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Obesity, Physical Activity, Diet
- Climate Change and Health Impacts
- Urinary Bladder and Prostate Research
- Cancer, Hypoxia, and Metabolism
- Bioinformatics and Genomic Networks
- Bone Metabolism and Diseases
- Hormonal and reproductive studies
- Acute Kidney Injury Research
- Cannabis and Cannabinoid Research
Brigham and Women's Hospital
2023-2025
Fudan University
2017-2024
Zhongshan Hospital
2020-2024
State Key Laboratory of Genetic Engineering
2017-2024
Harvard University
2023-2024
Broad Institute
2023-2024
The Technological College of Beer Sheva
2024
University of Massachusetts Amherst
2023
Massachusetts General Hospital
2023
Zhejiang University
2023
Abstract Background COVID-19 is an infectious disease characterized by multiple respiratory and extrapulmonary manifestations, including gastrointestinal symptoms. Although recent studies have linked gut microbiota to diseases such as influenza, little known about the role of in pathophysiology. Methods To better understand host-gut interactions COVID-19, we microbial community barrier function using metagenomic metaproteomic approaches 63 patients 8 non-infected controls. Both...
Genetic and genomic variation among microbial strains can dramatically influence their phenotypes environmental impact, including on human health. However, inferential methods for quantifying these differences have been lacking. Strain-level metagenomic profiling data has several features that make traditional statistical challenging to use, high dimensionality, extreme samples, complex phylogenetic relatedness. We present Anpan, a set of quantitative addressing three key challenges in...
Introduction:To explore the involvement of cardiovascular system in coronavirus disease 2019 , we investigated whether myocardial injury occurred COVID-19 patients and assessed performance serum high-sensitivity cardiac Troponin I (hs-cTnI) levels predicting severity 30-day in-hospital fatality.Methods: We included 244 patients, who were admitted to Renmin Hospital Wuhan University with no preexisting or renal dysfunction.We analyzed data including patients' clinical characteristics,...
Abstract Background Circulating levels of amino acids were associated with blood pressure (BP) in observational studies. However, the causation such associations has been hypothesized but is difficult to prove human Here, we aimed use two-sample Mendelian randomization analyses evaluate potential causal circulating BP and risk hypertension. Methods We generated genetic instruments for nine by conducting meta-analyses genome-wide association study (GWAS) UK Biobank participants metabolomic...
BackgroundOsteoporosis is a common metabolic bone disease, which always leads to osteoporotic fractures. Biomarkers of mineral density (BMD) are helpful for prevention and early diagnosis osteoporosis. This study aims identify metabolomic biomarkers low BMD.MethodsWe included 701 participants who had BMD measures by dual-energy X-ray absorptiometry scans donated fasting plasma samples from three clinical centres as discovery set another 278 the fourth centre an independent replication set....
OBJECTIVE To evaluate associations of oily and nonoily fish consumption oil supplements with incident type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We included 392,287 middle-aged older participants (55.0% women) in the UK Biobank who were free diabetes, major cardiovascular disease, cancer had information on habitual intake food groups use at baseline (2006–2010). Of these, 163,706 participated one to five rounds 24-h dietary recalls during 2009–2012. RESULTS During a median 10.1 years...
Abstract Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become wide-spread public health problem. However, is very heterogeneous, existing standard diagnostic measure not sufficient accurately identify all patients at osteoporotic guide therapy. Here, we constructed first prospective multi-omics atlas largest cohort date (longitudinal data from 366 participants three time points), also implemented an explainable data-intensive analysis...
Integrative analysis of high-quality metagenomics and metabolomics data from fecal samples provides novel clues for the mechanism underpinning gut microbe-human interactions. However, regarding influence collection methods on both are sparse. Six (the gold standard [GS] [i.e., immediate freezing at -80°C with no solution], 95% ethanol, RNAlater, OMNIgene Gut, occult blood test [FOBT] cards, Microlution) were used to collect 88 eight healthy volunteers whole-genome shotgun sequencing (WGSS)...
Background: Extending the healthspan – years of lived without disease is a public health priority. Healthy diets have been linked to lower chronic risk, but underlying mechanisms are largely unknown. We previously identified plasma multi-metabolite signatures that measure intakes and metabolic responses different dietary patterns. Hypothesis: Plasma heathy associated with longer healthspan. Methods: studied 12,478 participants from Nurses’ Health Studies Professional Follow-up Study who were...
Background: Obesity, a major risk factor for cardiovascular disease (CVD), is complex trait with substantial heterogeneity in its etiology, comorbidity risk, and prevention strategies. Hypothesis: Individuals early-onset obesity-related comorbidities ( vs. late-onset) carry different genetic loci obesity varied biological consequences. Methods: We examined longitudinal data from 43,567 participants the Nurses’ Health Studies Professionals Follow-Up Study, including biennial measurements of...
Background: Healthy diets are associated with lower risk of type 2 diabetes (T2D) risk, but it is unclear if individuals different genetic risks benefit from specific dietary strategies. Hypothesis: The associations between healthy patterns and T2D may be modified by global pathway-specific polygenic scores (PRS). Methods: We conducted prospective analyses in 40,609 participants the Nurses’ Health Studies Professionals Follow-Up Study, who were free baseline diabetes, cardiovascular disease,...
Introduction: Higher coffee consumption has been consistently associated with lower type 2 diabetes (T2D) risk but the underlying mechanisms are largely unknown. Our prior study showed higher intake was improved post-load glucose clarence and insulin sensitivity, visceral adiposity. Hypothesis: We hypothesized that decreased T2D risk, by lowering genetic susceptibility of in pathophysiological pathways related to production, central Methods: analyzed data from 333,053 UK Biobank participants...
Little is known regarding the association between intestinal motility patterns and cognitive function in individuals who are baseline cognitively healthy. The gut microbiome may contribute to association. We examined bowel movement (BM) pattern explored role of explaining this
Background: Contrast induced nephropathy (CIN) is a common complication in patients receiving intravascular contrast media. In 2020, the American College of Radiology and National Kidney Foundation issued new acute kidney injury (CI-AKI) criteria. Therefore, we aimed to explore potential risk factors for CIN under criteria, develop predictive model with coronary artery disease (CAD) relatively normal renal function (NRF). Methods: Patients undergoing angiography or percutaneous intervention...
Background Contemporary risk assessment in patients with coronary atherosclerotic disease (CAD) often relies on invasive angiography. However, we aimed to explore the potential of metabolomic biomarkers reflecting residual CAD after moderate lipid‐lowering therapy. Methods and Results We analyzed serum profile among 2560 newly diagnosed undergoing therapy, through nuclear magnetic resonance spectroscopy quantified 175 metabolites, predominantly lipoproteins their components. severity was...
The associations between visceral adipose tissue (VAT) and bone mineral density (BMD) or fracture have been controversial the causality of remains to be assessed. This study aimed explore VAT^ (predicted value VAT mass) with BMD risk in men women, examine their potential causation by two-sample Mendelian randomization (MR) analyses.UK Biobank is a large, population-based prospective cohort that recruited more than 500,000 participants aged 40-69 United Kingdom from 2006 2010. In this study,...
Bile acids (BAs) undergo extensive microbial metabolism in the gut and exert hormone-like functions on physiological processes underlying metabolic risk. However, extent to which BA profiles predict cardiometabolic risk explain individual responses dietary interventions humans is still unclear. In DIRECT-PLUS Trial, we conducted a multi-omics analysis of 284 participants randomized into three groups: healthy guidelines two Mediterranean diet (MedDiet) groups. We longitudinally measured 44...