A5100422665- Computational Drug Discovery Methods
- Synthesis and biological activity
- Optical measurement and interference techniques
- Cancer-related molecular mechanisms research
- Legume Nitrogen Fixing Symbiosis
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Vision and Imaging
- Video Surveillance and Tracking Methods
- Spondyloarthritis Studies and Treatments
- Seismic Waves and Analysis
- Plant and Fungal Species Descriptions
- Geotechnical Engineering and Underground Structures
- Geotechnical Engineering and Analysis
- Plant Stress Responses and Tolerance
- Sarcoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Lipid metabolism and disorders
- Genomics and Phylogenetic Studies
- Geophysical Methods and Applications
- Soil Carbon and Nitrogen Dynamics
- Agronomic Practices and Intercropping Systems
- Fire Detection and Safety Systems
- Rheumatoid Arthritis Research and Therapies
- PARP inhibition in cancer therapy
- Fern and Epiphyte Biology
Jilin University
2010-2025
Nanjing University
2021-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
Shanghai University of Traditional Chinese Medicine
2024
Fudan University
2024
Chinese PLA General Hospital
2023
Northeastern University
2018-2023
Central South University
2010-2023
General Hospital of Shenyang Military Region
2023
China University of Geosciences (Beijing)
2023
Maize ARGOS8 is a negative regulator of ethylene responses. A previous study has shown that transgenic plants constitutively overexpressing have reduced sensitivity and improved grain yield under drought stress conditions. To explore the targeted use native expression variation in drought-tolerant breeding, diverse set over 400 maize inbreds was examined for mRNA expression, but levels all lines were less than created original events. We then employed CRISPR-Cas-enabled advanced breeding...
The urban development of China is changing from incremental expansion to stock renewal mode. study functional areas has become one the important fundamental works in current and high-quality development. In recent years, big spatiotemporal data been well applied function field. However, spatial-temporal evolution characteristics forecasting optimization for mixed-use not examined well. Thus, this study, we proposed a new approach that applies revised information entropy method analyze...
It has been found that microRNAs (miRNAs) can function as a regulatory factor across species. For example, food-derived plant miRNAs may pass through the gastrointestinal (GI) tract, enter into plasma and serum of mammals, interact with endogenous RNAs to regulate their expression. Although this new type mechanism is not well understood, it provides fresh look at relationship between food consumption physiology. To investigate mechanism, we conducted systematic computational study analyze...
Despite great progress, the current cancer treatments often have obvious toxicity and side effects. a poor prognosis (some patients). One of reasons for is that certain enzymes prevent anticancer drugs from killing tumor cells. AKT1 involved in regulating PI3K/AKT/mTOR, tumor-generating pathway. Ipatasertib, highly selective inhibitor AKT1, widely used treatment tumors. In this study, many structural biochemical methodswere to find better AKT1(Threonine Kinase 1) inhibitors, which laid...
Abstract Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become wide-spread public health problem. However, is very heterogeneous, existing standard diagnostic measure not sufficient accurately identify all patients at osteoporotic guide therapy. Here, we constructed first prospective multi-omics atlas largest cohort date (longitudinal data from 366 participants three time points), also implemented an explainable data-intensive analysis...
Background: Cholesterol crystals in hepatocytes are known to strongly associate with human Metabolic Dysfunction-Associated Steatohepatitis (MASH). However, it remains unclear which molecular pathway(s) regulates free cholesterol accumulation, and therefore the formation of hepatocytes. In cultured cell lines, oxysterol-binding protein-related protein 2 (ORP2) functions deliver plasma membrane from internal organelles. Methods: Here, we generated liver-specific ORP2 knockout (ORP2-LKO) mice...
Soil salinization in farmland is a critical factor limiting global soil health, food security, and ecosystem productivity. Biochar has recently shown great application potential agricultural fields many domains, such as structure improvement, carbon sequestration, reductions greenhouse gas emissions. Here, meta-analysis of 113 published papers was carried out to quantify the effects biochar on remediation saline-alkali crop yield terms climatic conditions management, with aim determining...
Open biomass burning (OBB) in agriculture presents a significant and well-documented challenge, posing severe consequences for both environmental human health. OBB releases air pollutants that degrade quality contribute to climate change, leading premature deaths regions with high concentrations of open crop straw (OCSB) emissions. Although policies aimed at prohibiting are place, the efficacy these regulations mitigating OCSB emissions remains ambiguous. Consequently, early prevention...
Diabetic wounds significantly affect patient quality of life. Microneedles are a promising treatment to accelerate wound healing owing their high drug-loading capacity and efficient drug delivery; however, few studies date have comprehensively reviewed microneedles for diabetic healing. This up-to-date review summarizes the research progress in healing, including manufacturing materials techniques, structures, designs, release mechanisms, delivery substances, specific effects. study showed...
Epithelial-mesenchymal transition (EMT) is critical for tumor invasion and many other cell-relevant processes. While much progress has been made about EMT, no report concerns the EMT of cells on topological biomaterial interfaces with significant nuclear deformation. Herein, we prepared a poly(lactide-
Crop rotation increases crop yield, improves soil health, and reduces plant disease. However, few studies were conducted on the use of intensive cropping patterns to improve microenvironment saline soils. The present study thoroughly evaluated impact a three-year maize-peanut-millet pattern yield. rhizosphere was collected at maturity assess effects composition function microbial communities in different tillage layers (0-20 cm 20-40 cm) sandy saline-alkaline After three years rotation,...
Introduction Intercropping practices play a crucial role in enhancing and maintaining the biodiversity resiliency of agroecosystems, as well promoting stable high crop yields. Yet relationships between soil nitrogen, microbes, yield maize cultivated under maize/soybean intercropping systems remain unclear. Methods To fill that knowledge gap, here we collected rhizosphere at staminate stage after 6 consecutive years intercropping, to investigate how nitrogen application rates affected...
The aim of this research was to screen the ZINC15 database select lead compounds and drug candidates which can inhibit B-RAF (V600E). In order identify drugs potentially inhibited (V600E), numerous modules Discovery Studio 4.5 were employed. Structure-based screening using LibDock carried out followed by ADME (absorption, distribution, metabolism, excretion) toxicity prediction. CDOCKER performed demonstrate binding affinity mechanism between ligands B-RAF(V600E). To evaluate whether...
DNA double-strand breaks (DSBs) can be repaired by homologous recombination (HR) or non-homologous end joining (NHEJ). The mechanisms that govern whether a DSB is NHEJ HR remain unclear. Here, we characterise repair in the amoeba Dictyostelium. principal pathway responsible for resistance to DSBs during vegetative cell growth, stage of life cycle when cells are predominantly G2. However, illustrate restriction-enzyme-mediated integration into Dictyostelium genome possible this and mediated...
Subarachnoid hemorrhage (SAH) is an important cause of mortality in stroke patients. Long non‑coding RNAs (LncRNAs) have functions brain disease, however their expression profiles SAH remain to be elucidated. The present study aimed investigate the signatures LncRNAs and mRNAs early injury (EBI) following a rat model. Male Wistar rats were randomly divided into group sham operation group. temporal lobe cortex investigated using array experimental SAH. results revealed that there 144...
For old mines, numerous mining tunnels exist, which can potentially bring us closer to the deep ore-bearing structures. Therefore, we propose a surface-tunnel frequency domain electromagnetic (EM) method utilize these for geophysical exploration. In this method, transmitter is placed on Earth’s surface, while receiver positioned within tunnel space, providing higher resolution due its proximity target body. This paper presents derived analytical solution electric field in configuration. We...
This study was designed to screen ideal lead compounds and drug candidates with an inhibitory effect on PARP from the library (ZINC database).Two effective natural ZINC000003938684 ZINC000014811844 were found bind in ZINC database, showing a higher binding affinity. Also, they predicted have lower rodent carcinogenicity, Ames mutagenicity, developmental toxicity potential, high tolerance cytochrome P4502D6. Molecular dynamics simulation showed that had more favorable potential energies PARP,...
Homogeneous and gradient plasmonic arrays with tunable optical properties were fabricated by regulating the surface charge density of polymer films.
This paper aims to estimate the stability of water‐resistant strata between tunnel and small‐medium‐sized concealed cavity filled with high‐pressurized water or other fillings at optional position around through solving double‐hole problem. The analytical method identify critical thickness is proposed based on Schwarz alternating Griffith strength criterion, program calculate was prepared according this using mathematical software. Parametric study indicates that will increase buried depth...
Epithelial–mesenchymal transition (EMT) profoundly impacts prognosis and immunotherapy of clear cell renal carcinoma (ccRCC). However, not every patient is tested for EMT status because this requires additional genetic studies. In study, we developed an gene signature to classify the H&E-stained slides from The Cancer Genome Atlas (TCGA) into epithelial mesenchymal subtypes, then trained a deep convolutional neural network ccRCC which according our subtypes accurately automatically...
A uniform, large-scale particle-in-aperture hybrid array with well-defined nanoring hot spots is rationally designed and fabricated for highly reproducible SERS.