A5047832617- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Connective tissue disorders research
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Circular RNAs in diseases
- RNA modifications and cancer
- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Bone health and treatments
- Musculoskeletal pain and rehabilitation
- Vascular Malformations Diagnosis and Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Cerebral Venous Sinus Thrombosis
- Environmental DNA in Biodiversity Studies
- FOXO transcription factor regulation
- ATP Synthase and ATPases Research
- Cancer Research and Treatments
- Autophagy in Disease and Therapy
- Alkaline Phosphatase Research Studies
- Pomegranate: compositions and health benefits
- Intracerebral and Subarachnoid Hemorrhage Research
- Ubiquitin and proteasome pathways
- Wound Healing and Treatments
- Wnt/β-catenin signaling in development and cancer
Sir Run Run Shaw Hospital
2020-2024
Zhejiang University
2004-2024
Blood Center of Zhejiang Province
2020-2024
University of Science and Technology of China
2024
Qinghai University
2023
Harbin Medical University
2010-2022
First Affiliated Hospital of Harbin Medical University
2010-2022
Peking University People's Hospital
2018
Peking University
2018
Institute of Modern Physics
2004
Emerging evidence indicates that circRNAs are broadly expressed in osteosarcoma (OS) cells and play a crucial role OS progression. Recently, cancer-specific circRNA circPRKAR1B has been identified by high-throughput sequencing is recorded publicly available databases. Nevertheless, the detailed functions underlying mechanisms of remains poorly understood. By functional experiments, we found enhanced cell proliferation, migration, promotes epithelial-mesenchymal transition (EMT). Mechanistic...
The ubiquitin-proteasome system (UPS) plays a key role in maintaining protein homeostasis and bone remodelling.However, the of deubiquitinating enzymes (DUBs) resorption is still not well defined.Here, we identified deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) as negative regulator osteoclastogenesis by using GEO database, proteomic analysis, RNAi.Osteoclast-specific UCHL1 conditional knockout mice exhibited severe osteoporosis phenotype an ovariectomized model.Mechanistically,...
ABSTRACT Excessive bone resorption induced by increased osteoclast activity in postmenopausal women often causes osteoporosis. Although the pharmacological treatment of osteoporosis has been extensively developed, a safer and more effective is still needed. Here, we found that curcumenol (CUL), an antioxidant sesquiterpene isolated from Curcuma zedoaria, impaired receptor activator nuclear factor-κB (NF-κB) ligand (RANKL)-induced osteoclastogenesis vitro, whereas osteoblastogenesis MC3T3-E1...
Discogenic low back pain (LBP) is associated with nociceptive nerve fibers that grow into degenerated intervertebral discs (IVD) but the etiopathogenesis of disease not fully understood. The purpose this study was to clarify role Netrin-1 in causing discogenic LBP.The level innervation examined disc degenerative patients and rat needle-punctured models by immunohistochemistry. Nucleus pulposus (NP) cells were isolated from IVD tissues rats induced degeneration interleukin-1β (IL-1β) or tumor...
Background/Aims: Kaiso (ZBTB33) expression is closely associated with the progression of many cancers and microRNA (miRNA) processing. MiR-181a plays critical roles in multiple cancers; however, its precise mechanisms glioma have not been well clarified. The goal this study was to evaluate interaction between miR-181a glioma. Methods: Quantitative real-time PCR (qRT-PCR) performed detect levels tissues cell lines. Cell proliferation, invasion, epithelial–mesenchymal transition (EMT) were...
Subarachnoid hemorrhage (SAH) is an important cause of mortality in stroke patients. Long non‑coding RNAs (LncRNAs) have functions brain disease, however their expression profiles SAH remain to be elucidated. The present study aimed investigate the signatures LncRNAs and mRNAs early injury (EBI) following a rat model. Male Wistar rats were randomly divided into group sham operation group. temporal lobe cortex investigated using array experimental SAH. results revealed that there 144...
As the aging process progresses, age-related intervertebral disc degeneration (IVDD) is becoming an emerging public health issue. Site-1 protease (S1P) has recently been found to be associated with abnormal spinal development in patients mutations and multiple biological functions. Here, we discovered a reduction of S1P degenerated discs, primarily regulated by DNA methylation. Furthermore, through drug treatment siRNA-mediated knockdown, nucleus pulposus cells were more prone exhibit...
The treatment of chronic wound is an important topic current clinical issue. Neovascularization plays a crucial role in skin healing by delivering fresh nutrients and oxygen to the area. aim this study was investigate mechanisms urolithin A (UA) angiogenesis during healing. results vitro experiments showed that with UA (5-20 μM) promoted proliferation, migration, angiogenic capacity HUVECs. Furthermore, we investigated effect vivo using full-thickness model. Subsequently, found regeneration...
ABSTRACT Osteoporosis, a noteworthy age-related disease induced by imbalanced osteogenesis and osteoclastogenesis, is serious economic burden on both individuals society. Small molecule drugs with dual effects bone resorption mineralization are pressingly needed. Secreted frizzled-related protein 1 (SFRP1), well-known extracellular repressor of canonical Wnt signaling, has been reported to regulate osteogenesis. Global SFRP1 knockout mice show significantly elevated mass. Although...
Modic changes (MCs) and low back pain are highly correlated an economic burden to the society. Previous studies have shown that Cutibacterium acnes (C. acnes) infection can lead MCs. The purpose of this study was clarify whether how C. contributes oxidative stress nerve growth potentially leads pain. Neurons from hippocampus or dorsal root ganglion (DRG) Sprague-Dawley (SD) rats were cocultured with annulus fibrosus cells (AFCs) without presence supernatant in vitro. Cell viability, neurite...
Short tandem repeats (STRs) are the most frequently used genetic markers in forensic genetics due to their high diversities and abundant distributions human genome. Currently, combined DNA index system is commonly incorporated into various commercial kits for research. Some novel STRs that different from were not only assess complex paternity cases but also could provide more information higher efficiency combination with those STRs. In this study, we validated performance of a multiplex...
Background: Known as co-stimulatory molecule, programmed death ligand-2 (PD-L2) contributes to T-cell exhaustion by interaction with death-1 (PD-1) receptor, but its tumor cell intrinsic signal effects has been little investigated. Methods: PD-L2 expression was detected immunohistochemistry in 18 pairs of primary osteosarcoma tissues and matching lung metastasis tissues. We also investigated the knockdown on both vitro vivo. Results: In our study, elevated metastases compared according an...
We report a case of 57-year-old man with bilateral thalamic infarction due to DAVF, who underwent mistreatment initially. found simple medication was ineffective in treatment infarct DVAF, and patients might have better outcome if surgery performed prophase disease. Further more, MRA DSA should be as routine examination for suspected venous differences therapies.
Background Chronic subdural hematoma (cSDH) is a common neurosurgical pathology associated with older age. The burr hole drainage predominant technique lower incidence of recurrence and morbidity. blind placement the drain could result in intracerebral hemorrhage. This paper describes simple reliable for catheter cSDH to reduce Methods Forty-nine consecutive patients were treated Guidewire-assisted Drainage Catheter Placement Technique between July 2019 June 2021. Epidemiological, clinical...
Background: The homeobox gene MSX2 is involved in osteogenesis and plays an important role limb development. This study mainly explored the of growth development long bone, studied its effect on cartilage hypertrophy differentiation.Methods: We established Shh-Cre+/-; MSX2f/f mice used double staining skeleton Micro-CT to observe gross morphology difference. Then we histological analyze differences. Further, fetal regulatory chondrocyte related genes. Primary chondrocytes were then extracted...