A5102939083- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Autophagy in Disease and Therapy
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Cellular Mechanics and Interactions
- Sirtuins and Resveratrol in Medicine
- Hippo pathway signaling and YAP/TAZ
- Heat shock proteins research
- Axon Guidance and Neuronal Signaling
- Cancer, Hypoxia, and Metabolism
- Pneumocystis jirovecii pneumonia detection and treatment
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Circular RNAs in diseases
- Bioactive Natural Diterpenoids Research
- Wnt/β-catenin signaling in development and cancer
- Ubiquitin and proteasome pathways
- Molecular Biology Techniques and Applications
- Cannabis and Cannabinoid Research
- Radiopharmaceutical Chemistry and Applications
- Sulfur Compounds in Biology
TCM-Intigrated Cancer Center of Southern Medical University
2021-2023
Southern Medical University
2021-2023
Nanjing University of Chinese Medicine
2020-2021
Kanazawa University
2018-2020
Harbin Medical University
2014-2015
First Affiliated Hospital of Harbin Medical University
2014-2015
Glioma is the most common primary brain tumor in central nervous system (CNS) with high morbidity and mortality adults. Although standardized comprehensive therapy has been adapted, prognosis of glioma patients still frustrating thus novel therapeutic strategies are urgently need. Quercetin (Quer), an important flavonoid compound found many herbs, shown to be effective some models including glioma. Recently, it reported that adequate regulation autophagy can strengthen cytotoxic effect...
Background/Aims: Glioblastoma multiforme (GBM) is the most malignant primary brain tumor with a poor prognosis. Combination treatment of autophagy inducer and inhibitor may be feasible solution to improve therapeutic effects. However, correlation between them unclear. The purpose this study was investigate effect inhibition at different stages on cytotoxicity inducers in glioblastoma cells. Methods: Autophagy early stage achieved by 3-methyladenine (3-MA) or Beclin 1 shRNA. late chloroquine...
Abstract Cancer stem cells are associated with chemoresistance and rapid recurrence of malignant tumors, including glioblastoma (GBM). Although temozolomide (TMZ) is the most effective drug treatment for GBM, GBM acquire resistance become refractory to TMZ during treatment. Therefore, glioma cell (GSC)-targeted therapy TMZ-enhancing may be approaches improve prognosis. Many drugs that suppress signaling pathways maintain GSC or enhance effects have been reported. However, there no...
Rapid tumor progression, metastasis, and diagnosis in advanced stages of disease are the main reasons for short survival time high mortality rate patients with hepatocellular carcinoma (HCC). Ephrin A4 (EFNA4), ligand EPH family, participates development blood vessels epithelium by regulating cell migration rejection. In our study, based on bioinformatics analyses, we found that EFNA4 was highly expressed led to poor prognosis HCC. We demonstrated overexpression significantly promoted HCC...
We have previously shown that gelsolin (GSN) levels are significantly lower in the blood of patients with glioblastoma (GBM) than healthy controls. Here, we analyzed function GSN GBM and examined its clinical significance. Furthermore, microRNAs involved expression were also identified. The was determined using western blot analysis found to be samples normal ones. Gelsolin mainly localized astrocytes, immunohistochemistry immunofluorescence. Higher correlated more prolonged progression-free...
Long noncoding RNAs (lncRNAs) have been substantially reported to critical roles in regulating tumorigenesis recent years. However, the expression pattern and biological function of SNHG17 hepatocellular carcinoma (HCC) remain unclear. Bioinformatics analysis qRT-PCR were performed detect HCC tissues, adjacent nontumorous cell lines. The effect on proliferation, migration, apoptosis was investigated by knockdown overexpressing RNA sequencing utilized explore underlying mechanism. Utilizing...
Abstract Purpose This study was to explore whether Ginkgo biloba extract (GBE) improve memory impairment by alleviating neuroinflammation signaling in mice with status epilepticus. Methods The epilepticus (SE) model established pilocarpine and treated 100 mg / kg of GBE for 14 days. Spontaneous alternation Y‐maze new object recognition were used impairment. To examine glial cell activation, we performed immunohistochemistry immunofluorescence staining. activation NF‐κB the expression level...
Glioma persists as one of the most aggressive primary tumors central nervous system. cells are known to communicate with tumor-associated macrophages/microglia via various cytokines establish tumor microenvironment. However, how extracellular vesicles (EVs), emerging regulators cell-cell communication networks, function in this process is still elusive. We report here that glioma-derived EVs promote progression by affecting microglial gene expression an intracranial implantation glioma model...
Hepatocellular carcinoma (HCC) is one of the major causes cancer-related death worldwide. AHSA1 as a chaperone HSP90 promotes maturation, stability, and degradation related cancer-promoting proteins. However, regulatory mechanism biological function in HCC are largely unknown. Actually, we found that was significantly upregulated tissues cell lines notably correlated with poor clinical characteristics prognosis patients this study. Furthermore, both vitro vivo, gain- loss-of-function studies...
Background: Glioblastomas (GBMs) are aggressive malignant brain tumors. Although chemotherapy with temozolomide (TMZ) can extend patient survival, most patients eventually demonstrate resistance. Therefore, novel therapeutic agents that overcome TMZ chemoresistance required to improve outcomes. Purpose: Drug screening is an efficient method find new from existing drugs. In this study, we explored a anti-glioma agent by drug and analyzed its function respect GBM treatment for future clinical...
For hepatocellular carcinoma (HCC) patients, we attempted to establish a new oxidative stress (OS)-related prognostic model for predicting prognosis, exploring immune microenvironment, and the immunotherapy response. Significantly differently expressed stress-related genes (DEOSGs) between normal HCC samples from Cancer Genome Atlas (TCGA) were screened, then based on weighted gene coexpression network analysis (WGCNA), HCC-related hub discovered. Based least absolute shrinkage selection...
Cancer stem cells are associated with chemoresistance and rapid recurrence of malignant tumors including glioblastoma (GBM). Although temozolomide (TMZ) is the most effective drug against GBM to date, acquire resistance become refractory TMZ during treatment. Therefore, glioma cell (GSC)-targeted therapy enhancing may be approaches improve prognosis GBM. Many drugs that suppress signaling pathway related maintain GSC or enhance effect have been reported. However, there no established...
Abstract BackgroundRNA binding protein (RBP) plays a crucial role in tumorigenesis at post-transcriptional level various cancer types. Nevertheless, the of RBPs liver hepatocellular carcinoma (LIHC) remains obscure. We attempted to uncover association between and prognosis LIHC patients. MethodsWe analyzed transcriptome corresponding clinical data patients from genome atlas (TCGA) (training cohort) international consortium (ICGC) (validating database with series bioinformatics methods....
Abstract INTRODUCTION Glioblastoma (GBM) is the most common primary malignant brain tumors. Despite aggressive therapies, median overall survival of patients who suffered from GBM only 18 months. Furthermore, there no effective therapy for glioma stem cells (GSCs), which act as forming Herein, we newly identified pentamidine, an antiprotozoal drug, GSCs by using drug repositioning approach. METHOD We used patient-derived like cell lines KGS01, KGS07 were established at Kanazawa University....
Abstract BACKGROUND Among potential glioblastoma (GBM) blood biomarkers that we identified recently, focused on gelsolin (GSN), a key regulator of actin filament disassembly. GSN was significantly lower in the patients with GBM than healthy controls. In this study, analyzed function and microRNAs (miRs) involved expression GBM. METHODS QRT-PCR western blot were introduced to evaluate level normal brain tissue. The localization examined by immunohistochemistry immunocytochemistry using human...
Abstract BACKGROUND Glioblastoma (GBM) represents the most aggressive and frequent type of primary malignant brain tumors with a dismal clinical outcome. Though adjuvant temozolomide (TMZ) chemotherapy followed by surgical resection can extend patient`s post-operative survival, considerable number GBM cases are refractory to TMZ. Novel therapeutic agents that overcome chemoresistance against TMZ urgent. Drug repositioning is process identifying new indications for existing drugs provides...
Abstract INTRODUCTION Glioblastoma (GBM) is primary malignant brain tumor with poor prognosis. Despite aggressive chemoradiotherapies, GBM has resistance and finally relapses. Recently, it revealed that glioma stem cells (GSCs) are forming tumors induce the recurrence. However, there no effective therapy for GSCs. Herein, we newly identified pentamidine, an antiprotozoal drug, not only but also GSCs by using drug repositioning approach. METHOD We used two cell lines, A172 T98,...
Abstract Background Hepatocellular carcinoma (HCC) is one of the major causes cancer-related death worldwide. AHSA1 as a chaperone HSP90 promotes maturation, stability, and degradation related cancer-promoting proteins. However, regulatory mechanism biological function in HCC are largely unknown. The purpose this study to elaborate role development. Methods Real-Time PCR, Western blotting, Immunohistochemistry were used determine mRNA protein expression liver epithelial cells, tissues....
Abstract Background: Leukocyte immunoglobulin-like receptor subfamily B (LILRB), including 5 subtypes, is a group of inhibitory receptors in immune system. The LILRB family known to be involved the tumor progression various cancer types, especially liver cancer. However, expression patterns and prognostic values members tissues remain unclear. Methods: We used Oncomine database, GEPIA Kaplan–Meier Plotter, Timer, TISIDB cBioPortal assess value patients. also verified tumor-free at protein...