A5025695693- Traditional Chinese Medicine Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Phytochemical compounds biological activities
- Ginseng Biological Effects and Applications
- Synthesis and bioactivity of alkaloids
- Cell Adhesion Molecules Research
- Antibiotics Pharmacokinetics and Efficacy
- T-cell and B-cell Immunology
- Cancer therapeutics and mechanisms
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Synthesis and biological activity
- Pharmacological Effects of Natural Compounds
- Monoclonal and Polyclonal Antibodies Research
- Pharmacogenetics and Drug Metabolism
- Lung Cancer Research Studies
- Sphingolipid Metabolism and Signaling
- Microbial Metabolic Engineering and Bioproduction
- Synthesis and Biological Evaluation
- HIV Research and Treatment
- Heat shock proteins research
- Plant-based Medicinal Research
- Berberine and alkaloids research
- Spacecraft and Cryogenic Technologies
- Pneumocystis jirovecii pneumonia detection and treatment
North China University of Science and Technology
2022-2024
Southern Medical University
2004-2022
TCM-Intigrated Cancer Center of Southern Medical University
2022
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2019
Shenyang Pharmaceutical University
2017-2018
Nanfang Hospital
2004
Carbohydrate analysis can be used as a standard for quality control of industries plants, foods and pharmaceuticals. Quantitative 1H NMR spectroscopy (qNMR) is an excellent alternative to chromatography-based mixture analysis. However, the application qNMR in sugar has rarely been reported. In this study, performance was investigated compared with results from HPLC A head-to-head comparison (internal external methods) versus (PMP pre-column derivatization HPLC, HPLC-RID HPLC-ELSD) based on...
ABSTRACT Topotecan (TPT) is an important anti‐cancer drug that inhibits topoisomerase I. A sensitive and robust liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method potentially determines TPT in beagle dog plasma needed for a bioequivalence study of formulations. We developed validated LC‐MS/MS to evaluate terms specificity, linearity, precision, accuracy, stability, extraction recovery matrix effect. Plasma samples were treated with Ostro TM sorbent plate (a effective tool)...
Borneol (Bingpian), a monoterpenoid pharmaceutical ingredient, is commonly used as main composition in traditional Chinese medicine preparations such compound Danshen dropping pills (CDDP) and has also been approved by the U.S. Food Drug Administration flavoring substance or adjuvant food. plays regulating guiding role messenger drug CDDP. However, effect of borneol on pharmacokinetics components CDDP human plasma unclear. In this study, we investigate effects ginsenoside Rb1 (Rb1 ), Rg1...
Hepatocellular carcinoma (HCC) is one of the major causes cancer-related death worldwide. AHSA1 as a chaperone HSP90 promotes maturation, stability, and degradation related cancer-promoting proteins. However, regulatory mechanism biological function in HCC are largely unknown. Actually, we found that was significantly upregulated tissues cell lines notably correlated with poor clinical characteristics prognosis patients this study. Furthermore, both vitro vivo, gain- loss-of-function studies...
Patients who are coinfected with human immunodeficiency virus 1 (HIV) and Mycobacterium tuberculosis (TB) benefit from timely diagnosis treatment. In the present study frequencies of CD3+, CD4+, CD8+ T cells among peripheral blood mononuclear (PBMCs) patients in Kashi region China infected HIV, TB, both HIV TB (HIV-TB) were investigated to provide a basis for rapid identification patients.A total 62 or HIV-TB first hospitalized at our institution included study, as 30 controls. PBMCs...
Background: The seeds of Brucea javanica are known to be an abundant source quassinoids, which have a structurally diverse and wide spectrum biological effects, such as potential antiinflammatory, antitumor, antimalarial, antiamebic, cytotoxic activities. However, only several dehydro-quassinoids were isolated identified in this plant. Methods: EtOAc extract the B. was submitted silica gel CC, ODS, Sephadex LH-20, RP-HPLC get four compounds. Their chemical structures elucidated by...
Abstract Yiqi Fumai lyophilized injection (YQFM), a compound traditional Chinese medicine prescription derived from “Sheng Mai Powder,” is approved for the treatment of cardiovascular diseases. YQFM usually prescribed in combination with some Western medicines to treat patients, such as aspirin, nifedipine, and clopidogrel. However, herb–drug interactions (HDIs) are still unclear. We determined effect on drug metabolism‐related CYP450 enzymes by vitro assays. And effects pharmacokinetics or...
Compound Danshen dripping pills (CDDP), a well-known traditional Chinese medicine, is widely used to prevent and treat cardiovascular diseases. CDDP usually prescribed in combination with clopidogrel (CLP), but the herb-drug interactions are rarely reported. This study evaluated effects of on pharmacokinetics pharmacodynamics coadministered CLP, ensured safety efficacy their usage. The trial design included single-dose administration multidose test for 7 consecutive days. Wistar rats...
Salvianolic acids for injection (SAI) is developed from traditional Chinese medicine and approved the treatment of cardiovascular cerebrovascular diseases. Clopidogrel an inhibitor platelet aggregation, which often prescribed patients in combination with SAI. This present study aimed to assess effects SAI on pharmacogenomics, pharmacokinetics, pharmacodynamics clopidogrel, thereby ensuring safety efficacy coadministration. In vitro cytochrome P450 isoenzyme assays were performed human liver...
Abstract Bruceantinol (BOL), a quassinoid compound isolated from the fruits of Brucea javanica, has been reported to have cytotoxic and antibacterial effects. In this study, rapid, sensitive, specific ultra-performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) method was developed for quantitative determination BOL in rat plasma. The samples were treated by simple liquid-liquid extraction ethyl acetate separated on an UPLC BEH C18 column (2.1 mm × 50 mm) using 3-min...