A5102767758- Horticultural and Viticultural Research
- Plant biochemistry and biosynthesis
- Plant Water Relations and Carbon Dynamics
- Fermentation and Sensory Analysis
- Plant Gene Expression Analysis
- Pharmacological Effects of Natural Compounds
- Tissue Engineering and Regenerative Medicine
- Plant responses to elevated CO2
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Atmospheric chemistry and aerosols
- Fluoride Effects and Removal
- Natural product bioactivities and synthesis
- Adenosine and Purinergic Signaling
- Phytochemistry and Biological Activities
- Histone Deacetylase Inhibitors Research
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Liver physiology and pathology
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
- HIV/AIDS drug development and treatment
- Berberine and alkaloids research
- Forest ecology and management
- Metabolomics and Mass Spectrometry Studies
Zhengzhou Fruit Research Institute
2024-2025
Chinese Academy of Agricultural Sciences
2024-2025
First Affiliated Hospital of Henan University
2017-2024
Xinjiang Production and Construction Corps
2024
Clemson University
2020-2024
North China University of Science and Technology
2021-2023
Henan Polytechnic University
2020-2022
The Royal Free Hospital
2021
Xinjiang Agricultural University
2020-2021
University College London
2021
RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA 3D structure prediction. With agreement from crystallographers, structures are predicted by various groups before publication crystal structures. We now report prediction for six sequences: four nucleolytic ribozymes two riboswitches. Systematic protocols comparing models described analyzed. In these puzzles, we discuss (i) comparison between automated web servers human experts; (ii) coaxial stacking;...
The present study was conducted to evaluate the in vitro and vivo digestibility of dietary starch its digestive behaviour on systemic circulating amino acids (AA) weaned pigs. Eighteen weanling pigs surgically fitted with a catheter jugular vein were randomly assigned three treatment groups. Sticky rice (SRS) hydrolysed more quickly ( P < 0·05) than maize (MS) resistant (RS), almost completely within 4 h. different segments small intestine significantly different. SRS digested (81·9 %;...
Once-daily glecaprevir coformulated with pibrentasvir (glecaprevir/pibrentasvir) demonstrated high rates of sustained virologic response 12 weeks after treatment (SVR12) in patients hepatitis C virus (HCV) genotype 1–6 infection. This phase 3 study evaluated the efficacy and safety glecaprevir/pibrentasvir chronic HCV human immunodeficiency type 1 (HIV-1) coinfection, including compensated cirrhosis. EXPEDITION-2 was a 3, multicenter, open-label evaluating (300 mg/120 mg)...
Melatonin is a pleiotropic molecule which plays an important role in animal reproductive activities. Because of the increased global warming, impact heat stress (HS) on stockbreeding has become inevitable issue to be solved. To investigate potential effects melatonin vitro maturation porcine oocyte under HS, HS model for been used this study and different concentrations (10(-6) -10(-9) m) were also tested their protective oocytes. The polar body rate, index nuclear oocytes, cleavage rate as...
Abstract Proanthocyanidins (PAs) are important metabolites that enhance freezing tolerance of plants. Actinidia arguta , especially freezing‐tolerant germplasms, accumulate abundant PAs in dormant shoots and thereby tolerance, but the underlying mechanism is unknown. In this study, we used two A. with contrasting cold‐resistant phenotypes, KL RB, to explore mechanisms response cold tolerance. We determined a leucoanthocyanidin reductase gene ( AaLAR1 ) was more highly expressed than...
Purposes: To investigate whether valproic acid (VPA) has a neuroprotective effect against ischemia/reperfusion (I/R) injury in the rat retina, and to elucidate potential antioxidant mechanisms involved.Methods: Adult male Wistar rats were randomly divided into four groups: sham (group A), plus VPA B), I/R vehicle C), D). Retinal was produced by inducing an exceedingly high intraocular pressure (IOP). Prior insult, administered subcutaneously (300 mg/kg twice daily) for 7 days, after which...
RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA three-dimensional structure prediction. With agreement from structural biologists, structures are predicted by modeling groups before publication experimental structures. We report large-scale set predictions 18 for 23 RNA-Puzzles: 4 elements, 2 Aptamers, Viral 5 Ribozymes 8 Riboswitches. describe automatic assessment protocols comparisons between prediction experiment. Our analyses reveal some critical...
// Mingjing Meng 1, * , Shengnan Geng Zhenhua Du 1 Jingjing Yao Yaqiu Zheng Zibo Li Zhenzhen Zhang 2 Jiahuan Yongjian Duan and Gangjun Institute of Pharmacy, Pharmacy College Henan University, Jinming District, Kaifeng, Province 475004, China Department Oncology, The First Hospital Affiliated to 475001, These authors contributed equally this work Correspondence to: Du, email: 724200@henu.edu.cn Li, jiahuan1020@126.com Keywords: berberine, cinnamaldehyde, lung cancer, AMPK, AQP-1 Received:...
Abstract Although direct‐acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection are highly efficacious and safe, treatment initiation is often limited in patients with neuropsychiatric disorders due to concerns over reduced adherence drug–drug interactions. Here, we report adherence, efficacy, safety patient‐reported outcomes (PROs) from an integrated analysis of registrational studies using the pangenotypic DAA regimen glecaprevir pibrentasvir (G/P). Patients HCV genotypes...
The introduction of new preclinical models for in vitro drug discovery and testing based on 3D tissue-specific extracellular matrix (ECM) is very much awaited. This study was aimed at developing validating a co-culture model using decellularized human liver ECM scaffolds as platform anti-fibrotic anti-cancer testing. Decellularized obtained from healthy cirrhotic livers were bioengineered with LX2 HEPG2 single co-cultures up to 13 days validated drug-testing platform. Pro-fibrogenic markers...
The differences of pork quality characteristics among different pig breeds mainly came from the in myofiber type compositions. Growing evidence indicated key role miRNAs specification. In present study, we found that miR-152 is more abundant slow-twitch myofiber-enriched muscles. However, its transformation and myogenesis largely unknown. Overexpression porcine myotubes promoted formation myofibers myogenesis. While, inhibition expression showed opposite effect to mimics transfection....
Carbohydrate analysis can be used as a standard for quality control of industries plants, foods and pharmaceuticals. Quantitative 1H NMR spectroscopy (qNMR) is an excellent alternative to chromatography-based mixture analysis. However, the application qNMR in sugar has rarely been reported. In this study, performance was investigated compared with results from HPLC A head-to-head comparison (internal external methods) versus (PMP pre-column derivatization HPLC, HPLC-RID HPLC-ELSD) based on...
Hepatitis B virus (HBV) study is hampered by lacking of idea cell model which support effective HBV infection and meanwhile recapitulate hepatocyte biology function in vivo. In this study, we developed decellularized human liver scaffolds for culture further applied infection. As a result, primary hepatocytes (PHHs) engrafted into maintained differentiation with stable albumin secretion liver-specific gene expression. Comparing to mono-layer culture, scaffold-based three-dimensional (3D)...
Abstract Callicarpa kwangtungensis Chun is a traditional Chinese medicine that has various therapeutic effects. Despite its wide use in medicine, the study still quite limited, especially chemical compositions. In this research, an ultra‐high‐pressure liquid chromatography coupled with Q Exactive hybrid quadrupole‐orbitrap high‐resolution accurate mass spectrometry tandem method was utilized to analyze compositions for first time. As result, total of 124 compounds, including 20...