A5101606834- Mesenchymal stem cell research
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Advanced Photocatalysis Techniques
- dental development and anomalies
- Liver Disease and Transplantation
- RNA modifications and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- TiO2 Photocatalysis and Solar Cells
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- RNA and protein synthesis mechanisms
- Electrocatalysts for Energy Conversion
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Periodontal Regeneration and Treatments
- Organ Transplantation Techniques and Outcomes
- Oral and Maxillofacial Pathology
- Cancer-related molecular mechanisms research
- Viral Infections and Immunology Research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Hippo pathway signaling and YAP/TAZ
- Genomics and Phylogenetic Studies
- Autoimmune and Inflammatory Disorders Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Chongqing Medical University
2025
Hefei First People's Hospital
2024
University of Missouri
2021-2024
University of Tsukuba
2024
Fujian Provincial Hospital
2021-2023
Fujian Medical University
2021-2023
Xiangtan University
2023
Digital Research Alliance of Canada
2021-2023
Anhui Provincial Children's Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Background: The formation of dentin-pulp involves complex epithelial-mesenchymal interactions between Hertwig's epithelial root sheath cells (HERS) and dental papilla (DPCs). Earlier studies have identified some the regulatory molecules participating in crosstalk HERS DPCs dentin-pulp. In present study we focused on role HERS-secreted exosomes Specifically, hypothesized that exosome-like vesicles (ELVs) might mediate function trigger lineage-specific differentiation mesenchymal cells. To...
Dental pulp is critical to maintain the vitality of a tooth. Regeneration pulpo-dentinal complex great interest treat pulpitis and necrosis. In this study, through three-dimensional spheroid culture, group unique multipotent stem cells were identified from mouse dental papilla called regenerative (MDPSCs). MDPSCs exhibited enhanced osteogenic/odontogenic differentiation capabilities could form dentin neurovascular-like structures that mimicked native teeth in vivo. Further analysis revealed...
RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA three-dimensional structure prediction. With agreement from structural biologists, structures are predicted by modeling groups before publication experimental structures. We report large-scale set predictions 18 for 23 RNA-Puzzles: 4 elements, 2 Aptamers, Viral 5 Ribozymes 8 Riboswitches. describe automatic assessment protocols comparisons between prediction experiment. Our analyses reveal some critical...
The mean survival of metastatic lung adenocarcinoma is less than 1 year, highlighting the urgent need to understand mechanisms underlying its high mortality rate. role Extracellular vesicles (EVs) in facilitating interactions between cancer cells and microenvironment has garnered increasing attention. Previous studies on EVs metastasis have been primarily focused cell-derived modulating functions stromal cells. However, whether stem (CSCs) can alter properties non-CSC cells, EV crosstalk...
Mesoporous anatase-phase TiO2 hollow shells were successfully fabricated by the solvothermal and calcination process. This method involves preparation of SiO2@TiO2 core-shell colloidal templates, sequential deposition carbon then silica layers through sol-gel processes, crystallization finally removal inner outer to produce anatase shells. The prepared samples characterized transmission electron microscopy, X-ray diffraction, N2 adsorption-desorption isotherms UV-vis absorption spectroscopy....
Hertwig's epithelial root sheath (HERS) is important in guiding tooth formation by differentiating into cementoblasts through epithelial–mesenchymal transition (EMT) and inducing odontoblastic differentiation of dental papilla interaction (EMI) during the development. Thus, HERS cells are critical for cementum dentin might be a potential cell source to achieve regeneration. However, limited availability lifespan primary may represent an obstacle biological investigation therapeutic use...
Periodontal ligament stem cells (PDLSCs), as potential "seed cells" for periodontal tissue repair and regeneration, require to be expanded in vitro a large scale. Senescence of PDLSCs occurred during long-term culture may compromise the therapeutic effects PDLSCs. Medium supplements useful antisenescence. However, mechanisms vitamin C (Vc) treatment on are still unclear. In this study, we identified that Vc-treated maintained slender morphology, higher growth rate migration capacity,...
Hertwig's epithelial root sheath (HERS) plays indispensable roles in tooth development, including controlling the shape and number of roots, dentin formation, helping generate cementum.Based on these characteristics, HERS cell is a potential seed type for tooth-related tissue regeneration.However, application severely limited by lack appropriate culture methods small numbers.Methods: Here, we constructed 3D method to expand functional cells into spheroids, investigated characteristics dental...
Accurate prediction of RNA structure and folding stability has a far-reaching impact on our understanding functions. Here we develop Vfold2D-MC, new physics-based model, to predict thermodynamics from the sequence. The model employs virtual bond-based coarse-graining backbone conformation generates conformations through Monte Carlo sampling bond angles torsional bonds. Using coarse-grained statistical potential derived known structures, assign each with weight. weighted average over...
Wnt/β-catenin signaling has been well established as a potent inhibitor of adipogenesis. Here, we identified population adipocytes that exhibit persistent activity signaling, revealed by the Tcf/Lef-GFP reporter allele, in embryonic and adult mouse fat depots, named Wnt+ adipocytes. We showed this β-catenin-mediated activation these cells is Wnt ligand- receptor-independent but relies on AKT/mTOR pathway essential for cell survival. Such are distinct from classical ones transcriptomic...
Background: The link between malnutrition and poor prognosis in cardiovascular disease has been established but the association contrast-associated acute kidney injury (CA-AKI), a common complication of coronary procedures, remains poorly understood. In this study we investigated predictive value 3 nutritional indexes for CA-AKI patients undergoing percutaneous intervention (PCI).
Purpose The primary objective of this study was to recognize critical indicators in predicting blood glucose (BG) through data-driven methods and compare the prediction performance four tree-based ensemble models, i.e. bagging with tree regressors (bagging-decision [Bagging-DT]), AdaBoost (Adaboost-DT), random forest (RF) gradient boosting decision (GBDT). Design/methodology/approach This proposed a majority voting feature selection method by combining lasso regression Akaike information...
Abstract Hertwig's epithelial root sheath (HERS) is critical for epithelial–mesenchymal interaction (EMI) during tooth formation. However, the exact roles of HERS in odontogenic differentiation by EMI have not been well characterized, because primary cells are difficult to obtain. Immortalized cell lines constitute crucial scientific tools, while there few available. Our previous study has successfully established immortalized lines. Here, we confirmed phenotype our HERS‐H1 verifying its...
Previous studies have demonstrated that non-invasive liver fibrosis scores (LFSs) are associated with kidney function deterioration. This study aimed to assess the predictive performance of LFSs in contrast-associated acute injury (CA-AKI) coronary artery disease (CAD) patients undergoing elective percutaneous intervention (PCI). retrospective involved 5627 patients. The frequency CA-AKI was 6.3% (n = 353). In a multivariate logistic analysis after adjustment, LFSs, including fibrosis-5...
An efficient TiO 2− x photoanode based on thermal reduction was prepared and inhibited charge recombination by confining O V the 2 surface. Surface can facilitate electrode/electrolyte interface transfer water splitting.
The Trans-Activator Receptor (TAR) RNA, located at the 5'-end untranslated region (5' UTR) of human immunodeficiency virus type 1 (HIV-1), is pivotal in virus's life cycle. As initial functional domain, it folds during transcription viral mRNA. Although TAR's role recruiting Tat protein for trans-activation established, detailed kinetic mechanisms play early transcription, especially points temporary transcriptional pausing, remain elusive. Moreover, precise physical processes pause and...
Abstract Aim We investigated whether perioperative urine pH was associated with contrast-associated acute kidney injury (CA-AKI) in patients undergoing emergency percutaneous coronary intervention (PCI). Methods The study enrolled 1109 consecutive PCI. Patients were divided into three groups based on (5.0–6.0, 6.5– 7.0, 7.5–8.5). primary endpoint the development of CA-AKI, defined as an absolute increase ≥ 0.3 mg/dL or a relative 50% from baseline serum creatinine within 48 h after contrast...