A5101792400- Aquaculture disease management and microbiota
- Gene expression and cancer classification
- Invertebrate Immune Response Mechanisms
- Protein Structure and Dynamics
- Advanced Numerical Methods in Computational Mathematics
- Bioinformatics and Genomic Networks
- Plant Diversity and Evolution
- Vibrio bacteria research studies
- Mathematical Biology Tumor Growth
- Nanopore and Nanochannel Transport Studies
- Wound Healing and Treatments
- Esophageal Cancer Research and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Enzyme Structure and Function
- Glycosylation and Glycoproteins Research
- Infrastructure Maintenance and Monitoring
- Genetic diversity and population structure
- Radiomics and Machine Learning in Medical Imaging
- Biomedical Text Mining and Ontologies
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Plant and Fungal Species Descriptions
- Genetic Associations and Epidemiology
- Asphalt Pavement Performance Evaluation
Qingdao University of Science and Technology
2023-2025
Nanjing Drum Tower Hospital
2023-2024
Chinese Academy of Sciences
2015-2024
University of California, Irvine
2024
Yangzhou University
2020-2024
Zhejiang Medicine (China)
2024
University of California, San Diego
2018-2024
Nanjing Medical University
2023-2024
University of Chinese Academy of Sciences
2024
Institute of Mechanics
2024
The re-emergence of Zika virus (ZIKV) and Ebola (EBOV) poses serious continued threats to the global public health. Effective therapeutics for these maladies is an unmet need. Here, we show that emetine, anti-protozoal agent, potently inhibits ZIKV EBOV infection with a low nanomolar half maximal inhibitory concentration (IC50) in vitro potent activity vivo. Two mechanisms action emetine are identified: inhibition NS5 polymerase disruption lysosomal function. Emetine also entry. Cephaeline,...
Abstract Background Idiopathic Pulmonary Fibrosis (IPF) is a type of chronic interstitial pneumonia, often fatal, with elusive causes and bleak prognosis. Its treatment options are limited largely ineffective. Early detection precise diagnosis pivotal in managing the disease effectively enhancing patient survival rates. Recently, quest for trustworthy biomarkers IPF has gained momentum. Notably, emerging studies indicate that circular RNAs (circRNAs) found exosomes may hold significant...
Although research shows that waterborne epoxy resin emulsified asphalt (WER-EA) is an environmental protection material with potential high resistance to multiple types of pavement distress, its performance rather complicated and much affected by the curing agent value. This paper serves as a follow-up study preliminary published on evaluating impact value common agents mixtures. Four groups were filtered out prepare mixture samples, laboratory tests under low temperatures conducted....
Callitriche species are capable of purifying water, promoting wetland restoration, and providing natural shelters. Moreover, they can be utilized as horticultural plants for landscape greening. However, due to the threats climate change environmental degradation, some within this genus have been listed endangered. This study utilizes chloroplast genome analysis provide molecular evidence classification conservation these species. We conducted a comprehensive sequencing characterization...
Abstract Having comprehensive access to information on sheep behaviors is essential for acquiring relevant insights into the health status of and preventing diseases promptly. In particular, ruminating behavior tends reflect their digestive system. However, due challenging nature detecting behavior, traditional research has not yielded satisfactory results. fact, many computer vision-based methods do consider as a distinctive feature recognizing behavior. To this end, we proposed an...
Hertwig's epithelial root sheath (HERS) is important in guiding tooth formation by differentiating into cementoblasts through epithelial–mesenchymal transition (EMT) and inducing odontoblastic differentiation of dental papilla interaction (EMI) during the development. Thus, HERS cells are critical for cementum dentin might be a potential cell source to achieve regeneration. However, limited availability lifespan primary may represent an obstacle biological investigation therapeutic use...
In this study, we develop a stacked ensemble model that utilizes cell-free DNA (cfDNA) fragmentomics for the early detection of esophageal squamous cell carcinoma (ESCC). This incorporates four distinct features derived from whole-genome sequencing (WGS) and advanced machine learning algorithms robust analysis. It is validated across both an independent validation cohort external to ensure its generalizability effectiveness. Notably, maintains robustness in low-coverage environments,...
Prediction of runout distance and deposit morphology is great importance in hazard mitigation geophysical flows, including viscoplastic mudflows. The major rheological parameters mudflows, namely, yield stress viscosity, are crucial factors controlling the deposition processes. However, roles two parameters, especially mudflows with high inertia, remain poorly understood not accounted for scaling relations source volume. Here we investigate effects flow rheology on using small‐scale...
Aeromonas veronii is widespread in aquatic environments and responsible for infecting various animals. In this study, a dominant strain was isolated from the hepatopancreas of diseased Macrobrachium rosenbergii named JDM1-1. According to its morphological, physiological, biochemical characteristics molecular identification, isolate JDM1-1 identified as A. veronii. The results artificial challenge showed had high pathogenicity M. with an LD50 value 8.35 × 105 CFU/mL during test....
We propose a new neural network based method for solving inverse problems partial differential equations (PDEs) by formulating the PDE problem as bilevel optimization problem. At upper level, we minimize data loss with respect to parameters. lower train locally approximate solution operator in neighborhood of given set parameters, which enables an accurate approximation descent direction level The function includes L2 norms both residual and its derivative apply gradient simultaneously on...
Abstract Objective To develop a Chinese Diabetes Mellitus Ontology (CDMO) and explore methods for constructing high-quality biomedical ontologies. Materials We used various data sources, including clinical practice guidelines, expert consensus, literature, hospital information system database schema, to build the CDMO. combined top-down bottom-up strategies integrated text mining cross-lingual ontology mapping. The was validated by experts development tools, its application through decision...
Non-O1 Vibrio cholerae is a highly virulent pathogen which has seriously threatened the development of Macrobrachium nipponense in various farms. However, little information available relation to underlying mechanisms host-bacteria interaction M. nipponense. In this study, we performed transcriptome analysis at 6 and 12 h post-infection (hpi), differentially expressed genes (DEGs) (P<0.05) were revealed by comparison gene expression levels between hpi. The results showed that different...
We develop a hybrid approach that combines the Monte Carlo (MC) method, variational implicit-solvent model (VISM), and binary level-set method for simulation of biomolecular binding in an aqueous solvent. The solvation free energy complex is estimated by minimizing VISM free-energy functional all possible solute-solvent interfaces are used as dielectric boundaries. This consists solute volumetric, interfacial, van der Waals interaction, electrostatic energy. A technique shifting boundary to...
Abstract In addition to the backbone molecules of proteins and lipids, RNAs have recently been found be N-glycosylated as well in cell models. Some overlap N-glycans between RNA protein exist terms monosaccharide composition. Here we report a draft human tissue glycoRNA covering 12 typical organs characterized by mass spectrometry-based N-glycomics. were first prepared, then enzymatically released, hydrophilically enriched, permethylated, analyzed RPLC-MS/MS, finally identified N-glycan...
Chronic inflammation and lack of angiogenesis are the important pathological mechanisms in Deep Tissue Injury (DTI). Curcumin is a well-known anti-inflammatory antioxidant agent. However, curcumin unstable under acidic alkaline conditions can be rapidly metabolized excreted bile, which shortens its bioactivity efficacy.This study aimed to prepare curcumin-loaded poly (lactic-co-glycolic acid) nanoparticles (CPNPs) elucidate protective effects underlying wound healing DTI models.CPNPs were...
In this article, we apply the binary level set method to Variational Implicit Solvent Model (VISM), which is a theoretical and computational tool study biomolecular systems with complex topology.Central in VISM an effective free energy of all possible interfaces separating solutes (e.g., proteins) from solvent water).Previously, such functional minimized numerically by determine stable equilibrium conformations solvation energies.We vastly improve speed applying method, interface...
Genetic factors play significant roles in the tumorigenicity of lung cancer; however, there is lack systematic and large‐scale characterization pathogenic germline variants for cancer. In this study, 146 preselected cancer‐susceptibility genes were detected 17 904 Chinese cancer patients by clinical next‐generation sequencing. Among patients, 1738 (9.7%) carried 1840 pathogenic/likely (P/LP) from 87 genes. SBDS (SBDS ribosome maturation factor) (1.37%), TSHR (thyroid stimulating hormone...