A5088264643- Gout, Hyperuricemia, Uric Acid
- Growth Hormone and Insulin-like Growth Factors
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Nutrition and Health in Aging
- Spaceflight effects on biology
- Birth, Development, and Health
- Eosinophilic Disorders and Syndromes
- High Altitude and Hypoxia
- Pancreatic function and diabetes
- Case Reports on Hematomas
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular Disease and Adiposity
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Gestational Diabetes Research and Management
- Pharmacological Effects of Natural Compounds
- Industrial Technology and Control Systems
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Power Systems and Technologies
- Histiocytic Disorders and Treatments
- Dynamics and Control of Mechanical Systems
- Bone and Dental Protein Studies
- Cardiovascular and Diving-Related Complications
Chongqing Medical University
2014-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2014-2024
Peking University
2023-2024
Qingdao University
2011-2024
Affiliated Hospital of Qingdao University
2015-2024
117th Hospital of People's Liberation Army
2024
Nanjing Drum Tower Hospital
2024
China Geological Survey
2024
Ascension Providence Hospital
2023
Wayne State University
2023
The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia. loss humans during primate evolution causes their vulnerability to Thus, we generated a Uox-knockout model on pure C57BL/6J background using transcription activator-like effector nuclease (TALEN) technique. These mice spontaneously developed hyperuricemia (over 420 μmol/l) with about 40% survival up 62 weeks. Renal...
Accumulating clinical evidence suggests that hyperuricemia is associated with an increased risk of type 2 diabetes. However, it still unclear whether elevated levels uric acid can cause direct injury pancreatic β-cells. In this study, we examined the effects on β-cell viability and function. Uric solution or normal saline was administered intraperitoneally to mice daily for 4 weeks. acid-treated exhibited significantly impaired glucose tolerance lower insulin in response challenge than did...
Previous studies found elevated serum uric acid (SUA) was associated with the development or progression of non-alcoholic fatty liver disease (NAFLD) in general population; this study we aim to investigate association SUA and severity NAFLD based on grade ultrasonography non-obese subjects.Data were obtained from subjects via routine physical examinations Public Health Center our hospital between 2011 2014. The data included completed anthropometry blood biochemical indicators results...
BACKGROUND Colon cancer is one of the most common malignancies worldwide, and chemotherapy a widely used strategy in colon clinical therapy. Chemotherapy resistance main cause recurrence progression cancer. Thus, novel drugs for treatment are urgently needed. Tetramethylpyrazine (TMP), component traditional Chinese medicine Chuanxiong Hort, has been proven to exhibit beneficial effect tumors. AIM To investigate potential anticancer activity TMP underlying mechanisms. METHODS cells were...
Little is known about the relationship between serum uric acid (SUA) and cardio-ankle vascular index (CAVI) in Chinese population. Therefore, we aimed to investigate gender difference association of SUA CAVI a southwestern Data were obtained from subjects via routine physical examinations Public Health Center our hospital 2011 2014 Chongqing. The data included completed anthropometry blood biochemical indicators. recorded using an automatically VaseraVS-1000 screening system. We found...
It is generally believed that under normal conditions only B lymphocytes express immunoglobulin. Interestingly, our previous work demonstrated epithelial cancer tissues and cell lines also Ig alpha heavy chain. So we further analyzed the potential function of cancer-derived Here show blockade suppressed growth viability cells. And promotes malignant proliferation ability Furthermore, protein increases access percentage S phase from early mitosis synchronized Our findings support important...
Epidemiological studies have identified hyperuricemia as an independent risk factor for cardiovascular disease. However, the mechanism whereby causes atherosclerosis remains unclear. The objective of study was to establish a new rat model hyperuricemia‐induced atherosclerosis. Wistar‐Kyoto rats were randomly allocated either normal diet (ND), high‐fat (HFD), or high‐adenine (HAD), followed by sacrifice 4, 8, 12 weeks later. Serum uric acid and lipid levels analyzed, pathologic changes in...
Abstract Background The prevalence of hyperuricemia is increasing in adults, while the among adolescents seldom reported. Methods A cross-sectional survey by multistage, stratified sampling method was carried out Shandong Province during 2017–2018. total 9371 aged from 13 to 19 years were randomly sampled and analyzed this survey. Results overall mean serum uric acid (sUA) concentration 6.08 ± 1.57 mg/dL 25.4% 60.5% (when defined as sUA ≥ 7 or 5.5 mg/dL). Prevalence 42.3% (male) 8.0%...
To evaluate the three symptom indicators of scalp seborrheic dermatitis (SSD), namely flaking, maximum erythema area, and pruritus, to develop a "16-point scale," explore its relationship with severity SSD, verify reliability 16-point scale. A dermatologist evaluated patients SSD using scale, statistically analyzed collected data help SPSS 26.0 software. The measurement are expressed as (mean ± SD), intergroup comparison was done non-parametric test. We performed correlation analysis...
In this study, we develop a stacked ensemble model that utilizes cell-free DNA (cfDNA) fragmentomics for the early detection of esophageal squamous cell carcinoma (ESCC). This incorporates four distinct features derived from whole-genome sequencing (WGS) and advanced machine learning algorithms robust analysis. It is validated across both an independent validation cohort external to ensure its generalizability effectiveness. Notably, maintains robustness in low-coverage environments,...
Abstract Gout is a chronic disease resulting from elevated serum urate (SU). Previous genome-wide association studies (GWAS) have identified dozens of susceptibility loci for SU/gout, but few been conducted Chinese descent. Here, we try to extensively investigate whether these contribute gout risk in Han Chinese. A total 2255 variants linkage disequilibrium (LD) with GWAS SU/gout associated were analyzed cohort 1255 patients and 1848 controls. Cumulative genetic score analysis was performed...
<b>Purpose:</b> It has been demonstrated that metabolic risk factors were increased in adult growth hormone deficiency (AGHD) patients. Lipid accumulation product (LAP) is a novel biomarker of central lipid related to syndrome (MS), diabetes and cardiovascular disease. The aim this study was investigate the ability LAP identify MS AGHD Patients. <b>Materials methods:</b> In cross-sectional study, 75 patients controls matched with age gender enrolled. general anthropometries blood biochemical...