A5102774192- Pancreatic function and diabetes
- Extracellular vesicles in disease
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Phagocytosis and Immune Regulation
- Pancreatic and Hepatic Oncology Research
- Advanced Proteomics Techniques and Applications
- Gallbladder and Bile Duct Disorders
- Diet, Metabolism, and Disease
- Photoacoustic and Ultrasonic Imaging
- FOXO transcription factor regulation
- MicroRNA in disease regulation
- Diabetes and associated disorders
- Diagnosis and treatment of tuberculosis
- Ion Transport and Channel Regulation
- Endoplasmic Reticulum Stress and Disease
- Diabetes Treatment and Management
- Genomics, phytochemicals, and oxidative stress
- Lipid metabolism and disorders
- Chronic Kidney Disease and Diabetes
- Advanced Image Fusion Techniques
- Brain Tumor Detection and Classification
- Adsorption and biosorption for pollutant removal
Nanjing Medical University
2013-2025
Changzhou University
2022-2025
Hangzhou Red Cross Hospital
2022-2024
Wenzhou Medical University
2023
ShanghaiTech University
2023
Harvard University
2001-2023
Nagoya Women's University
2023
Kobe University
2023
Zhejiang University
2022
Nanjing Jiangning Hospital
2021
Autophagy is a dynamic physiological process that can generate energy and nutrients for cell survival during stress. regulate the migration invasive ability in cancer cells. However, connection between autophagy metabolism unclear. Monocarboxylate transporter 1 (MCT1) plays an important role lactic acid transport H+ clearance cells, Wnt/β-catenin signaling increase glycolysis. We investigated whether promotes glycolysis hepatocellular carcinoma (HCC) cells by activating pathway, accompanied...
In this study, fig branch biochar (FBB) was modified by chitosan to improve the Cd2+ adsorption performance from an aqueous solution. The surface area, pores, and functional groups of chitosan-modified (CMFBB) were characterized DTG-TGA, BET, SEM-EDS, FTIR, XRD. addition, impact various conditions on Cd analyzed, including dosage, initial pH, concentration, temperature, reaction time, coexisting cations. kinetics, isotherms, practical applications also investigated. Under optimized pH 6,...
Excessive production of triglyceride-rich VLDL is attributable to hypertriglyceridemia. facilitated by microsomal triglyceride transfer protein (MTP) in a rate-limiting step that regulated insulin. To characterize the underlying mechanism, we studied hepatic MTP regulation forkhead box O1 (FoxO1), transcription factor plays key role insulin signaling. In HepG2 cells, expression was induced FoxO1 and inhibited exposure This effect correlated with ability bind stimulate promoter activity....
Successful islet transplantation depends on the infusion of sufficiently large quantities islets, but only a fraction transplanted islets can survive and become engrafted, yet underlying mechanism remains unclear. In this study, we examined effect sirolimus, key component immunosuppressive regimen in clinical transplantation, engraftment function. To distinguish sirolimus immune rejection from its engraftment, used syngeneic model. Diabetic mice were with 250 under renal capsule, followed by...
A major therapeutic target in the search for a cure to devastating Alzheimer's disease is γ-secretase. This activity resides multiprotein enzyme complex responsible generation of Aβ42 peptides, precipitates which are thought cause disease. γ-Secretase also critical component Notch signal transduction pathway; signals regulate development and differentiation adult self-renewing cells. has led hypothesis that inhibition γ-secretase may interfere with Notch-related processes adults, most...
Accumulating clinical evidence suggests that hyperuricemia is associated with an increased risk of type 2 diabetes. However, it still unclear whether elevated levels uric acid can cause direct injury pancreatic β-cells. In this study, we examined the effects on β-cell viability and function. Uric solution or normal saline was administered intraperitoneally to mice daily for 4 weeks. acid-treated exhibited significantly impaired glucose tolerance lower insulin in response challenge than did...
High-fructose consumption is associated with insulin resistance and diabetic dyslipidemia, but the underlying mechanism unclear. We show in hamsters that high-fructose feeding stimulated forkhead box O1 (FoxO1) production promoted its nuclear redistribution liver, correlating augmented apolipoprotein C-III (apoC-III) impaired triglyceride metabolism. upregulated peroxisome proliferator-activated receptor-gamma coactivator-1beta sterol regulatory element binding protein-1c expression,...
Abstract Hepatic glucose and lipid metabolism disorders promote the development progression of type 2 diabetes mellitus (T2DM), yet underlying mechanisms are not fully understood. Here, we identify tripartite motif-containing protein 21 (TRIM21), a class IV TRIM family member, as pivotal regulator hepatic in T2DM for first time. Bioinformatic analysis suggests that TRIM21 expression is significantly reduced patients. Intriguingly, mouse model obese diabetes, predominantly liver rather than...
Peroxisome proliferator–activated receptors (PPARs) are nuclear transcription factors and play a central role in insulin sensitivity, lipid metabolism, inflammation. Both PPARα -γ expressed the kidney, their agonists exhibit renoprotective effects type 2 diabetes. In present studies, we investigated effect of PPARα/γ dual agonist tesaglitazar on diabetic nephropathy db/db mice. Treatment mice with for 3 months significantly lowered fasting plasma glucose homeostasis model assessment...
Recent studies have indicated that the development of acute and chronic kidney disease including renal fibrosis is associated with endoplasmic reticulum (ER) stress. S100 calcium-binding protein 16 (S100A16) as a novel member family involved in disease; however, few examined fibrotic kidneys for relationship between S100A16 ER In our previous study, we identified GRP78 partner HK-2 cells. Here, confirmed physical interaction cells markedly increased expression unilateral ureteral occlusion...
Pancreatic β-cell dysfunction caused by obesity can be associated with alterations in the levels of miRNAs. However, role miRNAs such processes remains elusive. Here, we show that pancreatic islet miR-27a-5p, which is markedly increased obese mice and impairs insulin secretion, mainly delivered visceral adipocyte–derived extracellular vesicles (EVs). Depleting miR-27a-5p significantly improved secretion glucose intolerance db/db mice. Supporting function EV as a key pathogenic factor,...
If unaligned multimodal medical images can be simultaneously aligned and fused using a single-stage approach within unified processing framework, it will not only achieve mutual promotion of dual tasks but also help reduce the complexity model. However, design this model faces challenge incompatible requirements for feature fusion alignment. To address challenge, paper proposes an image method called Bidirectional Stepwise Feature Alignment Fusion (BSFA-F) strategy. negative impact modality...
Successful islet transplantation depends on the infusion of sufficiently large quantities islets, but only a small fraction implanted islets become engrafted. The underlying mechanisms remain elusive. To probe mechanism revascularization, we determined effect angiopoietin-1 (Ang-1), proangiogenic and antiapoptotic factor, survival, function, revascularization transplanted using syngeneic model. Islets were transduced with adenoviruses expressing Ang-1 or control LacZ, followed by under renal...
Apolipoprotein A-V (apoA-V) and apoC-III are exchangeable constituents of VLDL HDL. ApoA-V counteracts the effect on triglyceride (TG) metabolism with poorly defined mechanisms. To better understand effects apoA-V TG cholesterol metabolism, we delivered cDNA into livers hypertriglyceridemic APOC3 transgenic mice by adenovirus-mediated gene transfer. In response to hepatic production, plasma levels were reduced significantly as a result enhanced catabolism without alternations in production....
Liver X receptors (LXRs), including LXRalpha and LXRbeta, are intracellular sterol sensors that regulate expression of genes controlling fatty acid cholesterol absorption, excretion, catabolism, cellular efflux. Because the kidney plays an important role in lipid metabolism dyslipidemia accelerates renal damage, we investigated effect TO-901317, LXR agonist, on gene profile mouse kidney. Treatment C57 Bl/6 mice with TO-901317 (3 mg.kg(-1).day(-1)) for 3 days resulted 51 transcripts were...