A5046131973- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- Diabetic Foot Ulcer Assessment and Management
- Extracellular vesicles in disease
- Wound Healing and Treatments
- Adipose Tissue and Metabolism
- Ultrasound and Hyperthermia Applications
- Pressure Ulcer Prevention and Management
- Photoacoustic and Ultrasonic Imaging
- Muscle metabolism and nutrition
- Planarian Biology and Electrostimulation
- Cardiovascular and exercise physiology
- Muscle activation and electromyography studies
- Bee Products Chemical Analysis
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Dermatologic Treatments and Research
- Laser Applications in Dentistry and Medicine
- Nutrition and Health in Aging
- Clinical Nutrition and Gastroenterology
- Vitamin C and Antioxidants Research
- Tendon Structure and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Heart Rate Variability and Autonomic Control
- Adipokines, Inflammation, and Metabolic Diseases
Kobe University
2016-2025
ShanghaiTech University
2023
Nagoya Women's University
2023
Icahn School of Medicine at Mount Sinai
2023
Harvard University
2020-2023
Nanjing Medical University
2023
Hyogo University of Health Sciences
2012-2023
University of Cambridge
2023
Kansai University
2019
Kobe International University
2014
Reactive oxygen species (ROS) production in disused skeletal muscle induces capillary regression, which disrupts the balance of pro- and anti-angiogenic factors. We tested whether green coffee bean extract containing rich chlorogenic acid, has antioxidant properties, can prevent regression caused by atrophy. The study included 24 female Sprague-Dawley rats, randomly assigned to four groups: control (CON), 2-week hindlimb unloading (HU), supplemented with acids (HU+50%CGA), trace amounts...
Objectives: Wheelchair seat sagging is hypothesized to increase pressure and shear forces, potentially leading injuries. The objective of this study was assess the impact correcting wheelchair on ischial pressure, force, posture in a population healthy adults. Methods: Twenty-four adults, meeting specific anthropometric requirements for proper fit, were recruited. Participants evaluated under two conditions: with base correction (With Correction) without it (No Correction). Correction...
Introduction Macrophages play an important role in the innate immunity. While macrophage inflammation is necessary for biological defense, it must be appropriately controlled. Extracellular vesicles (EVs) are small released from all types of cells and a central intercellular communication. Skeletal muscle has been suggested to release anti-inflammatory factors, but effect myotube-derived EVs on macrophages unknown. As mechanism macrophages, immune responsive gene 1 (IRG1)-itaconate pathway...
Immobilization induces skeletal muscle fibrosis characterized by increasing collagen synthesis in the perimysium and endomysium. Transforming growth factor-β1 (TGF-β1) is associated with this lesion via promoting differentiation of fibroblasts into myofibroblasts. In addition, reactive oxygen species (ROS) are shown to mediate TGF-β1-induced tissues. These reports suggest importance ROS reduction for attenuating fibrosis. Astaxanthin, a powerful antioxidant, has been reduce production...
This study aimed to investigate the effects of Brazilian propolis on body fat mass and levels adiponectin reactive oxygen species among community-dwelling elderly females. was a double-blind randomized placebo-controlled trial. Altogether, 78 females aged 66–84 years were randomly assigned (PRO; n = 39) or placebo (PLA; group. For 12 weeks, PRO group given three capsules containing 227 mg twice day. Meanwhile, PLA daily capsules. Of participants, 53 (PLA group: 28, 25) completed study....
Objective: In this study, we develop methods to measure galvanotaxis of fibroblasts and determined the optimum conditions electrical stimulation. Method: an inverted 35mm dish containing cell suspensions (3×10 5 primary human skin fibroblasts, DMEM, 10% FBS) was placed on centre a 100mm dish. The removed 24 hours later, culture medium added Fibroblasts were randomised (double-blind) into three groups, where stimulation given at varying intensities: 0μa (control), 50μa, 100μa. Electrical...
In this study, we develop methods to measure galvanotaxis of fibroblasts and determined the optimum conditions electrical stimulation.An inverted 35mm dish containing cell suspensions (3×105 primary human skin fibroblasts, DMEM, 10% FBS) was placed on centre a 100mm dish. The removed 24 hours later, culture medium added Fibroblasts were randomised (double-blind) into three groups, where stimulation given at varying intensities: 0UA (control), 50UA, 100UA. Electrical (frequency=0.3Hz)...
The effects of a combination the antioxidant astaxanthin (AX) and electrical stimulation (ES) on muscle mass mitochondrial oxidative capacity were investigated in soleus hindlimb unloaded rats. Five groups male Sprague-Dawley rats used; control, 1-week unloading (HU), HU + AX, ES, AX ES. Respective received 50-mg/kg twice daily during HU. Calf muscles ES electrically stimulated for 240 s/day One-week decreased along with FoxO3a phosphorylation increased ubiquitinated proteins expressions,...
The effects of malnutrition on skeletal muscle result in not only the loss mass but also fatigue intolerance. It remains unknown whether metabolic capacity is related to fiber type composition under malnourished condition although resulted preferential atrophy fast muscle. purpose present study was investigate and slow muscles via energy-sensing AMPK SIRT1 malnutrition. Wistar rats were randomly divided into control groups. group provided with a low-protein diet, daily food intake limited...
The purpose of the present study was to determine effects transcutaneous CO2 application on blood flow and capillary architecture soleus muscle in rats with streptozotocin (STZ)-induced hyperglycemia. Wistar were randomly divided into four groups: control, control + CO2-treated, STZ-induced hyperglycemia, hyperglycemia CO2-treated groups. Blood increased during exposure, continued increase for 30 min after treatment. In addition, attenuated a decrease expression level eNOS VEGF protein, an...
Background: A single, effective therapeutic regimen for keloids has not been established yet, and the development of novel approaches is expected. Butyrate, a short-chain fatty acid, docosahexaenoic acid (DHA), ω-3 polyunsaturated play multiple anti-inflammatory anticancer roles via their respective mechanisms action. Objective: In this study, we evaluated antifibrogenic effects single combined use on keloid fibroblasts. Methods: Keloid fibroblasts were treated with butyrate (0-16 mM) and/or...
The protective effects of Brazilian propolis on capillary regression induced by chronically neuromuscular inactivity were investigated in rat soleus muscle. Four groups male Wistar used this study; control (CON), plus supplementation (CON + PP), 2-week hindlimb unloading (HU), and (HU PP). rats the CON PP HU received two oral doses 500 mg/kg daily (total dose 1000 mg/kg) for 2 weeks. Unloading resulted a decrease number, luminal diameter, volume, an increase expression anti-angiogenic...
Abstract Inactivity can lead to muscle atrophy and capillary regression in skeletal muscle. Niacin (NA), known for inducing hypermetabolism, may help prevent this regression. In study involving adult female Sprague–Dawley rats, the animals were randomly assigned one of four groups: control (CON), hindlimb unloading (HU), NA, HU with NA supplementation (HU + NA). For a period 2 weeks, rats groups underwent HU, while those received (750 mg/kg) twice daily through oral administration. The...
Chronic neuromuscular inactivity induces capillary regression within skeletal muscle. The objective of this study was to investigate the potential effects dietary nucleic acids in counteracting reduction linked chronic soleus utilized four distinct groups female Wistar rats: a control group (CON), hindlimb-unloading (HU), an HU supplemented with DNA (HU + DNA), and RNA RNA). For duration two weeks, rats were administered 1500 mg/kg or orally on daily basis. Two weeks hindlimb unloading...
In this study, we evaluated the effect of hip-joint rotation on interface pressure over sacrum and greater trochanter with a new protocol for positioning bedridden elderly patients.The values in patients were evaluated. These collected supine position, 90° lateral 30° 40° laterally inclined positions external or neutral hip joint. Each was assessed device measuring distribution, after which, peak index (PPI) calculated.In 17 examined, PPI position significantly than that other positions....