A5040294318- Immune Response and Inflammation
- Inflammasome and immune disorders
- Fatty Acid Research and Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Clinical Nutrition and Gastroenterology
- Hydrogen's biological and therapeutic effects
- Neuroscience and Neuropharmacology Research
- Wound Healing and Treatments
- Respiratory Support and Mechanisms
- Protease and Inhibitor Mechanisms
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Fullerene Chemistry and Applications
- Sepsis Diagnosis and Treatment
- Carbon Nanotubes in Composites
- Dermatologic Treatments and Research
- Neurotransmitter Receptor Influence on Behavior
- Exercise and Physiological Responses
- Neonatal Health and Biochemistry
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Biochemical effects in animals
- Eicosanoids and Hypertension Pharmacology
- Diabetes Management and Research
- Diabetes and associated disorders
Hyogo University
2023-2024
Himeji Dokkyo University
2024
Hyogo Medical University
2012-2021
Okayama University
2021
Tokyo Metropolitan Institute of Gerontology
2021
Nippon Medical School
2021
Kobe University
2012-2019
Hyogo University of Health Sciences
2014-2016
Nara Institute of Science and Technology
2013
RMIT University
2013
Aim: Paracrine interaction between macrophages and adipocytes in obese visceral fat tissues is thought to be a trigger of chronic inflammation. The immunomodulatory effect the short chain fatty acid, butyric has been demonstrated. We hypothesize that sodium butyrate (butyrate) attenuates inflammatory responses lipolysis generated by adipocytes.Methods: Using contact or transwell co-culture methods with differentiated 3T3-L1 RAW264.7 macrophages, we investigated effects on production tumor...
The effect of morphine on tumor growth EL-4 leukemia in C57BL/6 mice and Sarcoma 180 carcinoma ddY was studied. Local subcutaneous enhanced by (10 mg/kg, s.c.) given daily for 10d. This inhibited preadministration the opioid antagonist naloxone. However, naloxone alone had no significant growth. Morphine also inoculated i.p. with P388 as well Meth-A cell Balb/c mice. incubation cultures EL-4, P388, MM-46 cells failed to enhance Mice displayed marked atrophy reduced cellularity spleen thymus....
The three different regioisomers of bis-N-methylfulleropyrrolidines have been separated by controlling the relative amounts γ-cyclodextrin and dimethyl sulfoxide (DMSO) contained in solutions these compounds. When a small amount γ-CDx was used mechanochemical high-speed vibration milling apparatus, trans-1 trans-2•γ-CDx complexes were from trans-3•γ-CDx complex. In contrast, trans-3 extracted relatively high ratio with an excess γ-CDx. addition DMSO to aqueous fullerene derivative•γ-CDx...
We have demonstrated that C60 derivatives bearing a pyrrolidine moiety as well variety of other substituents can form 1 : 2 complexes with γ-cyclodextrin (γ-CDx) using mechanochemical high-speed vibration milling apparatus. When the influence steric hindrance on formation was negligible, water-solubilities were shown experimentally to be completely dependent hydrophobic properties substituent. Furthermore, stabilities γ-CDx-complexes several different found similar or slightly higher than...
Because inhaled carbon monoxide (CO) provides potent anti-inflammatory and antioxidant effects against ischemia reperfusion injury, we hypothesized that treatment of organ donors with CO would decrease graft injury after heart transplantation. Hearts were heterotopically transplanted into syngeneic Lewis rats 8 hours cold preservation in University Wisconsin solution. Donor exposed to at a concentration 250 parts per million for 24 via gas-exposure chamber. Severity myocardial was determined...
Acute respiratory distress syndrome, which is caused by acute lung injury, a destructive disorder systemic inflammatory response. Persistent inflammation results in irreversible alveolar fibrosis. Because hydrogen gas possesses anti-inflammatory properties, we hypothesized that daily repeated inhalation of could suppress persistent inducing functional changes macrophages, and consequently inhibit fibrosis during late-phase injury.To test this hypothesis, injury was induced mice intratracheal...
Background: A single, effective therapeutic regimen for keloids has not been established yet, and the development of novel approaches is expected. Butyrate, a short-chain fatty acid, docosahexaenoic acid (DHA), ω-3 polyunsaturated play multiple anti-inflammatory anticancer roles via their respective mechanisms action. Objective: In this study, we evaluated antifibrogenic effects single combined use on keloid fibroblasts. Methods: Keloid fibroblasts were treated with butyrate (0-16 mM) and/or...
Although recruited neutrophils function as first-line defense to remove bacteria, delayed apoptosis is implicated in persistent inflammation leading organ injury. Leukotrien B4, n-6 polyunsaturated fatty acids (PUFAs) product, one of the mediators that delay neutrophil apoptosis. The mechanism beneficial effects supplementation fish oil-based long-chain n-3 PUFAs parenteral nutrition for critically ill patients has not been fully understood. One possible less inflammatory products can...
Abstract The enantiomers of some fullerene bisadducts were separated by complexation with γ-cyclodextrin (γ-CDx) in a mechanochemical high-speed vibration milling (HSVM) apparatus, followed decomplexation the addition DMSO. HSVM treatment, which is generally used for pharmaceutical preparation, was found to be governed not thermodynamic control but kinetic control.
Dysregulation of glucose metabolism, including hyperglycemia with insulin resistance, is commonly observed in critically ill patients. Interleukin-18 (IL-18) improves the resistance associated obesity, but relationship between IL-18 and metabolism sepsis was unclear. The purpose this study to investigate influence on during sepsis.Sepsis induced using cecal ligation puncture (CLP) wild-type (WT) mice, knockout (KO) KO mice pretreated recombinant IL-18. Blood plasma insulin, glucagon,...
Sex differences exist in sepsis, but the commitment of neutrophils to these remains unclear. Neutrophil extracellular traps (NETs) function remove pathogens, yet excessive NETs release can contribute organ damage. This study explores effects gender hormones on endotoxin-induced using from both male and female sources.
Chemical constituents of the root bark Toddalia asiatica (L.) LAM. (T. aculeata PERS.), Rutaceae, were examined. In addition to twelve known coumarins [toddaculin (2), coumurrayin (5), toddanone (6), 8-(3, 3-dimethylallyl)-6, 7-dimethoxycoumarin (7), isopimpinellin (8), 6-(3-chloro-2-hydroxy-3-methylbutyl)-5, (9), 6-formyllimettin (10), 5, 7, 8-trimethoxycoumarin (12), toddasin (13), (+)-toddanol (14), 6-(2-hydroxy-3-methoxy-3-methylbutyl)-5, (18), and toddalolactone (21)] five new...
The pathophysiologic features of acute respiratory distress syndrome (ARDS) are attributed to neutrophil accumulation and over-activation. Low blood immunoglobulin G concentrations in septic shock patients associated with higher risk developing ARDS. This study showed the effects intravenous (IVIg) on apoptosis lung during murine endotoxemia.Male C57BL/6J mice were injected saline or 7 mg/kg lipopolysaccharide (LPS), 3 h later also saline, IVIg 300 mg/kg, 1000 intraperitoneally. At 12 after...
Orchitis (testicular swelling) often occurs during systemic inflammatory conditions, such as sepsis. Interleukin 18 (IL18) is a proinflammatory cytokine and an apoptotic mediator endotoxemia, but the role of IL18 in response to inflammation testes was unclear. WT knockout (KO) mice were injected lipopolysaccharide (LPS) induce endotoxemia examined 12 48 h after LPS administration model acute recovery phases endotoxemia. Caspase activation assessed using immunohistochemistry. Protein mRNA...
Fish oil rich in n-3 polyunsaturated fatty acids has diverse immunomodulatory properties and attenuates acute lung injury when administered enternal nutrition. However, enteral nutrition is not always feasible. Therefore, we investigated the ability of parenteral supplemented with fish to ameliorate injury. Rats were infused solutions (without lipids, soybean oil, or oil) for three days. Lipopolysaccharide (15 mg/kg) was then intratracheally induce injury, characterized by impaired function,...