A5007357352- Dermatology and Skin Diseases
- Olfactory and Sensory Function Studies
- Allergic Rhinitis and Sensitization
- Advancements in Transdermal Drug Delivery
- Axon Guidance and Neuronal Signaling
- Mast cells and histamine
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Skin Protection and Aging
- Contact Dermatitis and Allergies
- Pain Mechanisms and Treatments
- Circadian rhythm and melatonin
- Toxin Mechanisms and Immunotoxins
- Polyamine Metabolism and Applications
- Urological Disorders and Treatments
- Hair Growth and Disorders
- Animal Genetics and Reproduction
- Psoriasis: Treatment and Pathogenesis
- Phytochemistry and Bioactive Compounds
- Cancer, Stress, Anesthesia, and Immune Response
- Stress Responses and Cortisol
- melanin and skin pigmentation
- Enzyme function and inhibition
- Neuropeptides and Animal Physiology
Juntendo University
2010-2020
Juntendo University Urayasu Hospital
2008-2020
Tokai University
2014-2016
Psoriasis is a complex, multifactorial inflammatory skin disease with genetic and environmental interactions. Patients psoriasis exhibit erythematous plaques itch, but the mechanisms of psoriatic itch are poorly understood.This study was performed to investigate epidermal nerve density opioid receptor levels in or without itch.Twenty-four patients aged between 39 82 years were included this study. The number fibres, semaphorin 3A (Sema3A) expression patterns μ- κ-opioid systems examined...
The effect of morphine on tumor growth EL-4 leukemia in C57BL/6 mice and Sarcoma 180 carcinoma ddY was studied. Local subcutaneous enhanced by (10 mg/kg, s.c.) given daily for 10d. This inhibited preadministration the opioid antagonist naloxone. However, naloxone alone had no significant growth. Morphine also inoculated i.p. with P388 as well Meth-A cell Balb/c mice. incubation cultures EL-4, P388, MM-46 cells failed to enhance Mice displayed marked atrophy reduced cellularity spleen thymus....
Epidermal hyperinnervation occurs in dermatoses with intractable pruritus, such as atopic dermatitis, suggesting that the is partly responsible for abnormal itch perception.To investigate mechanisms of penetration sensory nerve fibres into basement membrane skin.A rat dorsal root ganglion neurone culture system consisting Matrigel and a Boyden chamber containing growth factor (NGF) concentration gradient was used. In some experiments, matrix metalloproteinase (MMP) blockers semaphorin 3A...
Epidermal hyperinnervation is considered one cause of sensitization to itch, and thought regulated by keratinocyte-derived axonal guidance molecules, including nerve growth factor (NGF) semaphorin (Sema)3A. Neurotropin (NTP) shows antipruritic effects in allergic disease also used for pain relief. Using cultured rat dorsal root ganglion neurones, we previously found that NTP inhibited NGF-induced neurite outgrowth. However, no such inhibitory effect has been shown vivo. We therefore assessed...
Summary Background and Aims Pruritus frequently reduces quality of life ( QOL ) in patients with senile xerosis. This study investigated the moisturizing antipruritic effects a topical emollient containing diethylene glycol/dilinoleic acid copolymer (D/ DC pruritic Methods single‐blind involved 50 subjects, aged 50‐75 years. Patients were randomized to self‐applied treatment lower legs 10% (n = 20) or 20% D/ ‐containing cream, white petrolatum 5), no 5) thrice daily for four weeks. Clinical...
To reduce the incidence and severity of atopic dermatitis, detection treatment at an early stage are urgently required, but no effective biomarker has been reported. In this study, we attempted to detect a candidate dermatitis by focusing on levels nitrated residues in plasma proteins model mice (NC/Nga mice). We found that immunoglobulin (Ig) light chain was more highly animal than control mice. Western blot analysis showed statistically significant difference between 6-nitrotryptophan...
During the process of follicular atresia, cells are observed to invade zona pellucida (invasive cells) where they presumably play an important role in eliminating degraded oocytes. Although our preliminary studies have suggested that these may originate from granulosa and not macrophages, a detailed morphological analysis has been conducted. The objective this study was characterize more precisely by electron microscopy immunohistochemistry, using sexually immature mice. results show...
Abstract Kakato‐tsurutsuru (Kt) socks have been selling for almost 30 years in Japan. Wearers claim they improve heel dryness despite no scientific evidence. We investigated the effects of Kt on by questionnaire, clinical scores and non‐invasive skin measurements. In a double‐blind, randomized cross‐over study, 10 healthy volunteers wore control or over 2 weeks sequence 4 weeks. Skin hydration evaporation medial dorsal were measured before every week during trial. Clinical evaluations...
Increased epidermal nerve density is involved in intractable itch atopic dermatitis. Epidermal innervation regulated by the balance between growth factors (e.g. NGF) and repulsion semaphorin 3A, Sema3A) keratinocytes. Emollient ointment, UV-based therapy, Sema3A ointment cyclosporine administration decreased of fibers, resulting improvement itch. Retinoid-related orphan receptor α (RORα ) agonist LL-37 which induce keratinocytes may be a useful treatment