A5088868826- Peptidase Inhibition and Analysis
- Dermatology and Skin Diseases
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Psoriasis: Treatment and Pathogenesis
- Urticaria and Related Conditions
- Cancer, Hypoxia, and Metabolism
- Neuropeptides and Animal Physiology
- Glycosylation and Glycoproteins Research
- Cytokine Signaling Pathways and Interactions
- Gut microbiota and health
- Allergic Rhinitis and Sensitization
- Proteoglycans and glycosaminoglycans research
- TGF-β signaling in diseases
- Antimicrobial Peptides and Activities
- Barrier Structure and Function Studies
- Occupational and environmental lung diseases
- Nutrition, Health and Food Behavior
- Animal Virus Infections Studies
- Magnetic and transport properties of perovskites and related materials
- Melanoma and MAPK Pathways
- Pleural and Pulmonary Diseases
- Cardiovascular Issues in Pregnancy
- Axon Guidance and Neuronal Signaling
Juntendo University
2014-2024
Tokyo Metropolitan University
2022
Osaka Metropolitan University
2022
Ministry of Agriculture Forestry and Fisheries
2020
Ministry of Agriculture, Forestry and Fisheries
2020
Sakakibara Hospital
2018
Tokyo Medical and Dental University
2017
Yokohama City University
2012-2014
Kihara Institute for Biological Research
2012-2014
Showa Pharmaceutical University
2006-2008
Atopic dermatitis (AD), a chronic inflammatory skin disease, manifests as an intractable itch. Psychological stress has been suggested to play role in the onset and worsening of AD symptoms. However, pathophysiological relationships between psychological stressors cutaneous manifestations remain unclear. To elucidate mechanisms underlying stress-related exacerbation itch, we investigated effects water stress, restraint repeated social defeat on itch-related scratching behaviour, mechanical...
Abstract Angiomodulin (AGM) is a member of insulin‐like growth factor binding protein (IGFBP) superfamily and often called IGFBP‐ rP 1 or IGFBP‐7. AGM was originally identified as tumor‐derived cell adhesion factor, which highly accumulated in blood vessels human cancer tissues. also overexpressed cancer‐associated fibroblasts (CAFs) activates fibroblasts. However, some studies have shown tumor‐suppressing activity AGM. To understand the roles progression, we here investigated expression...
CD26/dipeptidyl peptidase IV is a cell surface glycoprotein which consists of multiple functional domains beside its ectopeptidase site. A growing body evidence indicates that elevated expression CD26 correlates with disease aggressiveness and invasive potential selected malignancies. To further explore the molecular mechanisms involved in this clinical behavior, our current work focused on interaction between CD9, were recently identified as novel markers for cancer stem cells malignant...
Although several assays are used to measure anti-receptor-binding domain (RBD) antibodies induced after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination, the not fully comparable in practice. This study evaluated immunogenicity of BNT162b2 mRNA vaccine healthy adults using two immunoassays. prospective cohort included SARS-CoV-2-naïve adults, predominantly healthcare workers, aged 20–64 years, who received doses between March and May 2021. Blood samples were collected...
Dupilumab attenuates itch and skin inflammation in patients with atopic dermatitis (AD). However, itch-related events that are improved by dupilumab remain unclear. Therefore, the present study investigated changes clinical scores, serum biomarkers, number of intraepidermal nerve fibers (IENFs) using biopsies blood samples from 12 moderate to severe AD before after treatment dupilumab. Clinical manifestations were assessed eczema area severity index (EASI) visual analogue scale (VAS) scores...
Abstract CD26 is associated with T cell signal transduction processes as a costimulatory molecule, and CD26+ cells have been suggested to be involved in the pathophysiology of diverse autoimmune diseases. Although cellular molecular mechanisms CD26-mediated activation extensively evaluated by our group others, potential negative feedback regulate still remain elucidated. In present study, we examine expression inhibitory molecules induced via costimulation. We show that coengagement CD3...
Interleukin (IL)-26, known as a Th17 cytokine, acts on various cell types and has multiple biological functions. Although its precise role still remains to be elucidated, IL-26 is suggested associated with the pathology of diverse chronic inflammatory diseases such psoriasis, bowel rheumatoid arthritis. To develop novel neutralizing anti-human monoclonal antibodies (mAbs) for therapeutic use in clinical setting, we immunized mice human protein. Hybridomas producing anti-IL-26 mAbs were...
Malignant pleural mesothelioma (MPM) is an aggressive neoplasm arising from mesothelial lining of pleura. CD26 molecules preferentially expressed on epithelioid type MPM. This study investigates the molecular mechanisms regulating MPM cells in vitro and vivo.Biochemical cell biological approaches were used for identifying a novel target Its contribution to tumour expansion has been also assessed using animal models. The clinical samples its expression.We identify that cytostatic effects are...
Angiomodulin ( AGM/IGFBP ‐ rP 1), a glycoprotein of about 30 kD a, is overexpressed in tumor vasculature as well some human cancer cell lines, but it has been suggested to be suppressor. To elucidate roles angiomodulin AGM ) progression, we here examined distribution three types tissues by immunohistochemistry. The results showed that was the stroma surrounding cells tissues. and α‐smooth muscle actin (α‐ SMA an activated fibroblast marker were often colocalized cancer‐associated fibroblasts...
Laminins present in the basement membranes (BM) of blood vessels are involved angiogenesis and other vascular functions that critical for tumor growth metastasis. Two major laminins, α4 (laminin-411/421) α5 (laminin-511/521) types, have been well characterized. We recently found a third type laminin, laminin-3B11, consisting α3B, β1 γ1 chains, revealed its biological activity. Laminin-3B11 potently stimulates endothelial cells to extend lamellipodial protrusions. To understand roles...
Laminin γ2 (Lmγ2) chain, a subunit of laminin-332, is typical molecular marker invading cancer cells, and its expression correlates with poor prognosis patients. It was previously found that forced Lmγ2 in cells promotes their invasive growth nude mice. However, the mechanism tumor-promoting activity remains unknown. Here we investigated interaction between vascular endothelial cells. When treated an N-terminal proteolytic fragment (γ2pf), HUVECs became markedly retracted or shrunken. The...
Hand-foot skin reaction (HFSR) is the most common adverse event of multikinase inhibitors (MKI), such as sorafenib. Although HFSR not life-threatening, severe cases impair quality life because pain and reduced activities daily living. However, pathological mechanisms have yet been elucidated in detail, there currently no effective treatment. We aimed to identify keratinocyte cytoprotectants against sorafenib toxicity.The screening toxicity was performed using cultured normal human epidermal...
A T cell costimulatory molecule with dipeptidyl peptidase IV (DPPIV) activity in its extracellular region, CD26 is a multifunctional associated various proteins such as adenosine deaminase, caveolin-1, CXCR4, collagen, and fibronectin, while playing an important role the regulation of inflammatory responses tumor biology. We have focused on novel therapeutic target for tumors immune disorders, developed humanized anti-CD26 monoclonal antibody (mAb), YS110, which currently being evaluated...