A5065263281- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Olfactory and Sensory Function Studies
- Crystallography and molecular interactions
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Superconducting Materials and Applications
- Advanced Chemical Sensor Technologies
- Cardiac Valve Diseases and Treatments
- Diabetes Management and Research
- Biochemical Analysis and Sensing Techniques
- Potato Plant Research
- Nutritional Studies and Diet
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- FOXO transcription factor regulation
- Parkinson's Disease and Spinal Disorders
- Vagus Nerve Stimulation Research
- Heat Transfer and Boiling Studies
- Adipose Tissue and Metabolism
- Inflammatory Myopathies and Dermatomyositis
- Genomics, phytochemicals, and oxidative stress
- Natural Antidiabetic Agents Studies
- Luminescence Properties of Advanced Materials
- Cardiovascular Health and Disease Prevention
Kanazawa Medical University
2011-2024
Tohoku University
2017-2024
Kyushu University
1997-2024
Teikyo University
2015-2024
Osaki Citizen Hospital
2023-2024
Cambridge University Press
2023
New York University Press
2023
Kyoto Institute of Technology
2023
Ichinomiya Kenshin College
2023
Azabu University
2016-2022
The liver possesses a high regenerative capacity. Liver regeneration is compensatory response overcoming disturbances of whole-body homeostasis provoked by organ defects. Here we show that vagus-macrophage-hepatocyte link regulates acute after injury and this system critical for promoting survival. Hepatic Foxm1 rapidly upregulated partial hepatectomy (PHx). branch vagotomy (HV) suppresses upregulation hepatocyte proliferation, thereby increasing mortality. In addition, hepatic FoxM1...
Under insulin-resistant conditions such as obesity, pancreatic β-cells proliferate to prevent blood glucose elevations. A liver-brain-pancreas neuronal relay plays an important role in this process. Here, we show the molecular mechanism underlying compensatory β-cell proliferation. We identify FoxM1 activation islets from relay-stimulated mice. Blockade of relay, including vagotomy, inhibits obesity-induced pathway and suppresses expansion. Inducible β-cell-specific deficiency also blocks In...
The enhancement of insulin secretion and the proliferation pancreatic β cells are promising therapeutic options for diabetes. Signals from vagal nerve regulate both processes, yet effectiveness stimulating is unclear, owing to a lack techniques doing it so selectively prolongedly. Here we report two optogenetic methods vagal-nerve stimulation that led enhanced glucose-stimulated cell in mice expressing choline acetyltransferase-channelrhodopsin 2. One method involves subdiaphragmatic...
We examined the effect of perfluorooctanoic acid (PFOA) on adipose cells using 3T3-L1 adipocytes and found that PFOA increased adipocyte differentiation, triglyceride accumulation, mRNA level factors related to differentiation. In addition, bound peroxisome proliferator-activated receptor γ (PPAR γ). These results suggest promotes differentiation as a PPAR ligand.
Recent progress in direct lineage reprogramming has enabled the generation of induced hepatocyte-like (iHep) cells and revealed their potential as an alternative to hepatocytes for medical applications. However, hepatic functions iHep are insufficient compared with those primary hepatocytes. Here, we show that cell-aggregate formation can rapidly induce growth arrest maturation through activation Hippo signaling. During cell aggregates, Yap inactivation is by actin reorganization...
Anamorelin (ANAM) is a novel ghrelin receptor agonist for the treatment of cancer cachexia. In clinical trials ANAM, glucose metabolism disorders as adverse effects were relatively frequent, however, when and how they occur remains unclear. Moreover, safety in patients with pancreatic and/or diabetes has not been clarified because most previous studies focused on non-small cell lung had excluded poorly controlled diabetes. Herein, 66-year-old man advanced was administered acute hyperglycemia...
As universidades brasileiras são constituídas pelo tripé ensino, pesquisa e extensão. A extensão universitária é comumente a forma em que as instituições de ensino superior concedem seus serviços à comunidade aonde inseridas, repassando o conhecimento produzido, capacitando os profissionais ali formados com vivência social. Muitos cursos, inclusive Odontologia, têm suas grades curriculares presença da participação práticas extensionistas. O projeto “Restauração dentes tratados...
CMOS image sensors with rolling exposure have come to be widely used, but they cannot avoid the distortion inherent no matter how much speed improves for capturing a moving target. The need has consequently been felt global-shutter sensors.
In liver development, hepatoblasts that act as hepatic stem/progenitor cells proliferate and differentiate into both hepatocytes cholangiocytes to form tissues. Although numerous factors contribute this event, little is known about the roles of microRNAs in hepatoblast proliferation differentiation. study, we focused on lineage‐28 (Lin28) family proteins, which are required for microRNA regulation pluripotent stem cancer cells, investigated their regulatory properties hepatoblasts....
In this study, the antidiabetic effects of a hot water extract edible Chrysanthemum morifolium Ramat. (HW-ECM) were investigated in type 2 diabetic mice. HW-ECM improved blood glucose levels and insulin resistance increased adiponectin mRNA expression adipose tissues protein concentrations plasma. Moreover, it expressions peroxisome proliferator-activated receptor γ (PPARγ), regulator transcription, its downstream target genes. It also reduced cell size attenuated pro-inflammatory...
Hepatocytes play important roles in the liver, but culture, they immediately lose function and dedifferentiate into progenitor-like cells. Although this unique feature is well-known, dynamics mechanisms of hepatocyte dedifferentiation differentiation potential dedifferentiated hepatocytes (dediHeps) require further investigation. Here, we employ a culture system specifically established for hepatic progenitor cells to study dedifferentiation. We found that with hybrid epithelial/mesenchymal...
The aim of this study was to assess whether migration thallium-201 ((201)Tl) the olfactory bulb were reduced in patients with impairments comparison healthy volunteers after nasal administration (201)Tl.10 and 21 enrolled (19 males 12 females; 26-71 years old). causes dysfunction head trauma (n = 7), upper respiratory tract infection chronic rhinosinusitis 7). (201)TlCl administered unilaterally cleft, SPECT-CT conducted 24 h later. Separate MRI images merged SPECT images. (201)Tl also...
Due to concerns of carcinogenicity, it is necessary assess long-term acrylamide exposure in individuals. Whether the available methods estimating intake can indicate remains unknown. We examined variations estimated dietary Japanese population.The study included 240 participants aged 40-74 years who were a part Japan Public Health Center-based Prospective Study for Next Generation (JPHC-NEXT). Twelve-day records (DRs) collected over one-year period, and food frequency questionnaires (FFQs)...
Obesity is directly associated with cancer, cardiovascular injury, hypertension, and type 2 diabetes. To date, Yamamoto identified that hot water extracts of edible Chrysanthemum (EC) induced cell size reduction, up-regulation adiponectin expression, glucose absorption inhibition in 3T3-L1 cells during adipocyte differentiation. Furthermore, EC showed antidiabetic effects such as improvement insulin resistance the down-regulation blood level liver lipid content diabetes model mice. In this...
Malignant pleural mesothelioma (MPM) is an aggressive neoplasm arising from mesothelial lining of pleura. CD26 molecules preferentially expressed on epithelioid type MPM. This study investigates the molecular mechanisms regulating MPM cells in vitro and vivo.Biochemical cell biological approaches were used for identifying a novel target Its contribution to tumour expansion has been also assessed using animal models. The clinical samples its expression.We identify that cytostatic effects are...
We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among compounds, luteolin, diosmetin, and chrysoeriol partly inhibited by blocking accumulation triacylglycerol Conversely, tricetin facilitated The induction lipogenesis or lipolysis may depend number bonding position hydroxyl methoxy groups B ring 5,7-dihydroxyflavone. mRNA expression levels adipogenic lipogenic genes were suppressed luteolin treatment cells, while lipolytic not affected....
Whether basal β-cell proliferation during adulthood is involved in maintaining sufficient mass, and if so, the molecular mechanism(s) underlying remain unclear. FoxM1 a critical transcription factor which known to play roles 'adaptive' proliferation, facilitates rapid increases mass response increased insulin demands. Therefore, herein we focused on of 'basal' under normal conditions maintenance as well glucose homeostasis adulthood.FoxM1 deficiency was induced specifically β-cells...
Although sarcopenia is common in patients with Alzheimer's disease (AD), the neural substrates involved remain unclear. We investigated relationship between sarcopenia, as well its definition components, and regional cerebral blood flow (rCBF) older adults progression of normal cognition to AD.99m Tc-ethyl-cysteinate-dimer single-photon emission computed tomography was carried out 95 AD (40 men 55 women, mean ± SD age 80.9 6.8 years). The associations rCBF determined by 3-D stereotactic...
Few studies have investigated the effects of Okinawan vegetable consumption on risk incident stroke and coronary heart disease. This study aimed to examine associations vegetable, fruit, with disease in Japanese population Okinawa.The design was a prospective cohort study. During 1995-1998, validated food frequency questionnaire administered two areas 16,498 participants aged 45-74 years. In 217,467 person-years follow-up until end 2012, total 839 cases 197 were identified.No statistically...
The adipose tissue is an endocrine organ, and its function closely related to type 2 diabetes. Edible Chrysanthemum morifolium Ramat. (ECM) possesses several biological properties; however, effect on adipocytes remains unclear. We investigated the of hot water extract ECM (HW-ECM) 3T3-L1 adipocytes. HW-ECM enhanced adipocyte differentiation, adiponectin secretion, glucose uptake in cells. It also increased mRNA levels peroxisome proliferator-activated receptor γ (PPARγ), a regulator...
Abstract Cell proliferation processes play pivotal roles in timely adaptation to many biological situations. Herein, we establish a highly sensitive and simple strategy by which time-series showing the of targeted cell type can be quantitatively monitored vivo same individuals. We generate mice expressing secreted luciferase only cells producing Cre under control Ki67 promoter. Crossing these with tissue-specific Cre-expressing allows us monitor time course pancreatic β-cells, are few number...