A5068962427- Bioactive natural compounds
- Natural product bioactivities and synthesis
- Organoselenium and organotellurium chemistry
- Synthesis and Biological Evaluation
- Free Radicals and Antioxidants
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Metabolism, Diabetes, and Cancer
- Phytochemicals and Antioxidant Activities
- Pancreatic function and diabetes
- Fatty Acid Research and Health
- Peroxisome Proliferator-Activated Receptors
- Bamboo properties and applications
- Pharmacological Effects of Natural Compounds
- melanin and skin pigmentation
- Synthesis and biological activity
- Phytochemistry and biological activity of medicinal plants
- Sulfur-Based Synthesis Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Synthesis of Organic Compounds
- Microbial Metabolism and Applications
- Magnolia and Illicium research
- Phytoestrogen effects and research
- Pain Mechanisms and Treatments
- Drug Transport and Resistance Mechanisms
Nihon University
2015-2024
Tokai Gakuen University
2023-2024
Tokai University
2023
Gunma Industrial Technology Center
2004-2010
Yonezawa Women's Junior College
2010
NOF Corporation (Japan)
1991-1994
Tokyo University of Marine Science and Technology
1983
Delayed wound healing reduces the quality of life (QOL) patients. Thus, understanding mechanism is indispensable for better management. However, role innate immunity in thus far unknown. Recently involvement TLR3 has been evaluated. The systemic administration polyriboinosinic-polyribocytidylic acid (poly I:C ; a substitute viral dsRNA and ligand toll-like receptor 3), enhances vivo. aim this study to improve our link between human healing, particularly re-epithelialization. present showed...
Abstract We studied the molecular evolution of haemagglutinin ( H ) gene (full length) in all genotypes (24 genotypes, 297 strains) measles virus (MeV). The gene’s evolutionary timescale was estimated by Bayesian Markov chain Monte Carlo (MCMC) method. also analysed positive selection sites. MCMC tree indicated that MeV diverged from rinderpest (same genus) about 250 years ago and 24 formed 3 lineages dating back to a 1915 ancestor (95% highest posterior density [HPD] 1882–1941) with...
Favipiravir was initially developed as an antiviral drug against influenza and is currently used in clinical trials severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (COVID-19). This agent presumably involved RNA chain termination during virus replication, although the molecular interactions underlying its potential impact on coronaviruses including SARS-CoV-2, SARS-CoV, Middle East coronavirus (MERS-CoV) remain unclear. We performed silico studies to elucidate detailed...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2,6-Dimethoxy-p-benzoquinone as an antibacterial substance in the bark of Phyllostachys heterocycla var. pubescens, a species thick-stemmed bambooAtsuyoshi Nishina, Kinichi Hasegawa, Tsuyoshi Uchibori, Hajime Seino, and Toshihiko OsawaCite this: J. Agric. Food Chem. 1991, 39, 2, 266–269Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://doi.org/10.1021/jf00002a009RIGHTS &...
Many natural products that inhibit melanogenesis, freckles, and hyperpigmentation have been selectively used in cosmetics because melanogenesis is linked to the multiple biogenesis cascades of melanin synthesis. However, some these compounds side effects may result their restriction future. We report here isolation structural elucidation extracted from Mansonia gagei evaluate activity on inhibition. isolated five known M. identified them as mansonone E (1), mansorin I (2), populene F (3), G...
Obesity is directly associated with cancer, cardiovascular injury, hypertension, and type 2 diabetes. To date, Yamamoto identified that hot water extracts of edible Chrysanthemum (EC) induced cell size reduction, up-regulation adiponectin expression, glucose absorption inhibition in 3T3-L1 cells during adipocyte differentiation. Furthermore, EC showed antidiabetic effects such as improvement insulin resistance the down-regulation blood level liver lipid content diabetes model mice. In this...
We investigated the superoxide anion scavenging effects of thirteen 2-amino-1,3-selenazoles using a highly sensitive quantitative chemiluminescence method. At 166 μM, scavenged in range 14.3 to 96.7% O2−. 2-Piperidino-1,3-selenazole and 4-phenyl-2-piperidino-1,3-selenazole exhibited strongest anion-scavenging activity among 2-amino-1,3-selenazoles. The 50% inhibitory concentrations (IC50) 2-piperidino-1,3-selenazole were determined be 4.03 μM 92.6 respectively. Thus, these compounds acted...
DNA gyrase plays important roles in genome replication various bacteria, including Pseudomonasaeruginosa. The gyrA gene encodes the subunit A protein (GyrA). Mutations GyrA are associated with resistance to quinolone-based antibiotics. We performed a detailed molecular evolutionary analyses of and quinolone drug, ciprofloxacin, using bioinformatics techniques. produced an phylogenetic tree Bayesian Markov Chain Monte Carlo (MCMC) method. This indicated that common ancestor was present over...
The increased number of patients with type 2 diabetes (T2D) has become a worldwide problem, and insulin sensitizers such as thiazolidinediones (TZDs) are used therapeutic agents. We found that extracts Vitex trifolia L. (V. trifolia), medicinal plant from Myanmar, induced adipogenesis similar to rosiglitazone (ROS), which is TZD, in 3T3-L1 preadipocytes. In the present study, we attempted isolate V. those compounds showed ROS-like effects. Among hexane, ethyl acetate, methanol obtained...
We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among compounds, luteolin, diosmetin, and chrysoeriol partly inhibited by blocking accumulation triacylglycerol Conversely, tricetin facilitated The induction lipogenesis or lipolysis may depend number bonding position hydroxyl methoxy groups B ring 5,7-dihydroxyflavone. mRNA expression levels adipogenic lipogenic genes were suppressed luteolin treatment cells, while lipolytic not affected....
Abstract A substance with antioxidant properties was obtained from the hexane extract of roots Rumex japonicus Houtt. The active component isolated and characterized as 2‐acetyl‐1,8‐dihydroxy‐3‐methyl naphthalene, trivially named musizin (MUS). activities MUS in six types fats oils were higher than that butyl hydroxyanisole (BHA) δ‐tocopherol (δ‐TOC). Together, TOC have a synergistic effect, because comparable amounts either had lower activity various combinations two antioxidants. When we...
Eleutherococcus sieboldianus (Makino) Koidz. is a local product from the area in and around Yonezawa City Yamagata Prefecture, Japan. It has been used as medicinal plant for long time. We isolated identified four types of flavonoid glycosides [astragalin (1), isoquercetin (2), rhamnocitrin 3-O-glucoside (3), nicotiflorin (4)], triterpene [methyl hederagenin (5)], three [δ-hederin (6), echinocystic acid 3-O-arabinoside (7), cauloside B (8)] methanol extract E. sieboldianus, which regulates...
We investigated the superoxide anion scavenging effects of 2-amino-1,3- selenazoles and bis-(2-amino-5-selenazoyl) ketones using a highly sensitive quantitative chemiluminescence method. At 166 μM, 2-amino-1,3-selenazoles scavenged in range 10.0 to 80.0% O2−. Bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone exhibited strongest anion-scavenging activity among six kinds three ketones. The 50% inhibitory concentration (IC50) bis[2-dimethylamino-5-(1,3-selenazolyl)] was determined be 37.1 μM....
Abstract This study aimed to chemically isolate and explore an antimelanogenesis inducer in extracts of Solanum melongena L. “Usukawamarunasu” eggplant. We successfully identified dioscin ([25R]‐Spirost‐5‐en‐3β‐yl) 2‐ O ‐(6‐deoxy‐α‐ l ‐mannopyranosyl) ‐ 4‐ ‐mannopyranosyl)‐β‐ d ‐glucopyranoside] the plant, examined effects α‐melanocyte‐stimulating hormone (MSH)–induced melanogenesis B16 murine melanoma cells by this plant‐derived dioscin. Immunoblot analysis suggested that reduced expression...
ORIGINAL RESEARCH article Front. Microbiol., 15 November 2010Sec. Virology https://doi.org/10.3389/fmicb.2010.00124
It is known that black soybean (BS) extract, rich in polyphenols, has beneficial effects against obesity, inflammation and insulin resistance. However, detailed of BS on lipid metabolism have not been documented well. In the present study, we compared fatty acid composition visceral subcutaneous adipose tissues high-fat fed (HFF) rats administered HFF rats. Black administration for 6 weeks influenced neither body nor tissue weights, blood glucose, plasma levels, or sensitivity. reduced...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntimicrobial components, trachrysone and 2-methoxystypandrone, in Rumex japonicus HouttAtsuyoshi. Nishina, Kohji. Kubota, Toshihiko. OsawaCite this: J. Agric. Food Chem. 1993, 41, 10, 1772–1775Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/jf00034a047https://doi.org/10.1021/jf00034a047research-articleACS PublicationsRequest reuse...