A5101768406- Adipose Tissue and Metabolism
- Phytoestrogen effects and research
- Metabolism, Diabetes, and Cancer
- Fatty Acid Research and Health
- Cancer Cells and Metastasis
- Digestive system and related health
- Estrogen and related hormone effects
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- GDF15 and Related Biomarkers
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Biochemical Analysis and Sensing Techniques
- Biochemical effects in animals
- Cardiac Health and Mental Health
- Spectroscopy and Quantum Chemical Studies
- Regulation of Appetite and Obesity
- Immune Cell Function and Interaction
- Muscle metabolism and nutrition
- Cancer, Hypoxia, and Metabolism
- Photosynthetic Processes and Mechanisms
- Bone health and osteoporosis research
- Medicinal Plant Extracts Effects
- Photoreceptor and optogenetics research
- Bone Metabolism and Diseases
Tokyo University of Agriculture
2011-2022
Heidelberg University
2014-2015
National Institute of Infectious Diseases
2011-2015
National Institute of Biomedical Innovation, Health and Nutrition
2015
National Institute of Health Sciences
2014
Nutritional Research Foundation
2010
Maximal oxygen uptake (VO(2max)) predicts mortality and is associated with endurance performance. Trained subjects have a high VO(2max) due to cardiac output metabolic capacity of skeletal muscles. Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), nuclear coactivator, promotes mitochondrial biogenesis, fiber-type switch oxidative fibers, angiogenesis in muscle. Because exercise training increases PGC-1α muscle, PGC-1α-mediated changes may contribute the improvement...
There are three isoforms of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) mRNA, which promotes mitochondrial biogenesis in skeletal muscles. Compared with PGC-1α-a PGC-1α-b or PGC-1α-c mRNA is transcribed by a different exon 1 the PGC-1α gene. In this study, effects exercise intensity and 5-aminoimidazole-4-carboxamide-1β-d-ribofuranoside (AICAR) on isoform-specific expressions were investigated. All increased proportion to treadmill running (10-30 m/min for 30 min)....
Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1α (PGC-1α) is a of various nuclear receptors and other transcription factors, which involved in the regulation energy metabolism, thermogenesis, biological processes that control phenotypic characteristics organ systems including skeletal muscle. PGC-1α muscle considered to be contractile protein function, mitochondrial metabolic regulation, intracellular signaling, transcriptional responses. Branched-chain amino acid (BCAA)...
Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1α (PGC-1α) is a of various nuclear receptors and other transcription factors whose expression increases in the skeletal muscle during exercise. We have previously made transgenic mice overexpressing PGC-1α (PGC-1α-Tg mice). upregulates genes associated with red fibers, mitochondrial function, fatty acid oxidation, branched chain amino (BCAA) degradation. However, global analyses actual metabolic products not been investigated....
In this study, the antidiabetic effects of a hot water extract edible Chrysanthemum morifolium Ramat. (HW-ECM) were investigated in type 2 diabetic mice. HW-ECM improved blood glucose levels and insulin resistance increased adiponectin mRNA expression adipose tissues protein concentrations plasma. Moreover, it expressions peroxisome proliferator-activated receptor γ (PPARγ), regulator transcription, its downstream target genes. It also reduced cell size attenuated pro-inflammatory...
Soy isoflavones, genistein, daidzein and its metabolite equol, as well β-carotene have been reported to be effective for maintaining bone health. However, it remains elucidated whether combining soy isoflavones with is beneficial formation. This study investigated the combined effect of on differentiation MC3T3-E1 preosteoblastic cells. Daidzein genistein alone did not affect cell growth but increased alkaline phosphatase (ALP) activity. Beta-carotene inhibited markedly enhanced ALP resulted...
The different effects of deoxynivalenol (DON) on intestinal barrier and stem cells by its route exposure remain less known. We explored the toxic DON functions after microinjection (luminal exposure) or addition to a culture medium (basolateral using three-dimensional mouse organoids (enteroids). influx test fluorescein-labeled dextran showed that basolateral (1 micromolar (µM) disrupted in enteroids compared with luminal at same concentration. Moreover, an immunofluorescence experiment...
S-equol is a natural metabolite of the soy isoflavone, daidzein, produced by intestinal bacteria. has been shown to have greater estrogenic activity than other isoflavones and prevent bone loss in post-menopausal women. Estrogen regulates both remodeling hemopoiesis marrow, these processes that communicate closely with each other. In this study, we investigated effect on mass gene expression marrow cells ovariectomized (OVX) mice. Female ddY strain mice, aged 12 weeks, were either sham...
Osteoclasts play a major role in bone resorption. Several functional food components, such as soy isoflavones and carotenoids, are reported to inhibit osteoclast formation. However, the cooperative effect of foods or their constituents on metabolism has not been clarified. This study aimed investigate carotenoids formation vitro using cultures RAW264 marrow cells presence receptor activator nuclear factor κ-B ligand. In cells, treatment with (genistein equol) (β-carotene) suppressed At 10...
LKB1 phosphorylates members of the AMP-activated protein kinase (AMPK) family. and AMPK in skeletal muscle are believed to regulate not only fuel oxidation during exercise but also capacity. was required prevent diaphragm fatigue, which shown affect performance. Using mice expressing dominant negative (DN) mutants AMPK, specifically heart, we investigated roles activity performance effects these kinases on characteristics respiratory locomotive muscles. In gastrocnemius, both AMPK-DN LKB1-DN...
Feeding a high-cholesterol diet with water-soluble peanut skin polyphenol fraction to rats reduced their plasma cholesterol level, an increase in fecal excretion. The hypocholesterolemic effect was greater the lower-molecular-weight rather than higher-molecular-weight fraction. This possibly due some oligomeric polyphenols which solubility of dietary intestinal bile acid-emulsified micelles.
In this study, we investigated the synergistic effects of daidzein (Dz) and kiwifruit on bone equol production in ovariectomised (OVX) rats. Female Sprague-Dawley rats were randomly assigned to one five groups: sham operated, OVX control, fed 0.1% Dz-supplemented diet (OVX + Dz), Dz green (GRK)-supplemented GRK) gold (GOK)-supplemented GOK). There no significant differences whole body femur mineral density (BMD) among groups at week 8. BMD group significantly decreased 8; however, GRK was...
Kiwifruit is a good source of dietary components and has beneficial effects for health. In this study, we investigated the two types kiwifruit, green kiwifruit (GRK) gold (GOK), on bone metabolism in ovariectomized (OVX) mice. Seven-week-old female Balb/c-strain mice were divided into four groups: sham-operated (sham) group, OVX that fed GRK-supplemented diet or GOK-supplemented diet. Freeze-dried GRK GOK prepared added at concentration 3 g/100 g. After 9 wk, sacrificed, serum, uterus,...
The adipose tissue is an endocrine organ, and its function closely related to type 2 diabetes. Edible Chrysanthemum morifolium Ramat. (ECM) possesses several biological properties; however, effect on adipocytes remains unclear. We investigated the of hot water extract ECM (HW-ECM) 3T3-L1 adipocytes. HW-ECM enhanced adipocyte differentiation, adiponectin secretion, glucose uptake in cells. It also increased mRNA levels peroxisome proliferator-activated receptor γ (PPARγ), a regulator...
Retinoid X receptor (RXR) γ is a nuclear receptor-type transcription factor expressed mostly in skeletal muscle, and regulated by nutritional conditions. Previously, we established transgenic mice overexpressing RXRγ muscle (RXRγ mice), which showed lower blood glucose than the control mice. Here investigated their metabolism.RXRγ were subjected to insulin tolerance tests, transporter expression levels, hyperinsulinemic-euglycemic clamp uptake analyzed. Microarray bioinformatics analyses...
We examined whether the combination of isoflavone and milk basic protein both are reported to be effective for bone metabolism, prevents loss induced by skeletal hind-limb unloading in mice. Female ddY strain mice, aged 8 weeks, were divided into six groups (n = 6–8 each): (1) normally housed group, (2) loading (3) group fed a control diet, (4) 0.2% conjugates (5) 1.0% (6) diet. After 3 femoral mineral density was markedly reduced The showed cooperative effects preventing inhibited increased...
Adenosine signaling is involved in glucose metabolism hepatocytes and myocytes vitro. However, no information available regarding the effect of adenosine on vivo. Thus, we examined how extracellular acts using mice. Subcutaneous injections (10, 25, 50 mg/kg bodyweight) dose-dependently increased blood levels, with peak occurring at 30 min post injection. At after injection (25 bodyweight), glycogen content liver, but not skeletal muscle, was significantly decreased. Hepatic depletion by...
Exercise has acute and chronic effects on fat burning. Concerning the effect, observed during after a single exercise session, enzymes responsible for burning increase. Carnitine palmitoyltransferase 1 (CPT1), which regulates β-oxidation of fatty acids in mitochondria, is believed to play an important role effect. The activation AMP-activated protein kinase (AMPK), detects energy state muscles, may contribute exercise-induced CPT1. In effect with ongoing training, physiological changes...
New Zealand is a rich source of food components that may have bioactivity on bone.Docosahexaenoic acid (DHA) from fish oil has been shown to maintain bone in ovariectomised (OVX) rats.Kiwifruit, fibre and carotenoids, also affect via prebiotic as well direct cell-based mechanisms.We aimed 1) ascertain the effects DHA two cell models, including interactions with soy isoflavones; 2) investigate specific carotenoids kiwifruit whole rodent models human study.RAW 264.7 mouse monocytes or marrow...