Joji Kotani
A5068452757- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Nosocomial Infections in ICU
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Immune Response and Inflammation
- Respiratory Support and Mechanisms
- Trauma and Emergency Care Studies
- Hemodynamic Monitoring and Therapy
- Frailty in Older Adults
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Arrest and Resuscitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Inflammasome and immune disorders
- Emergency and Acute Care Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neuroinflammation and Neurodegeneration Mechanisms
- Thermal Regulation in Medicine
- Airway Management and Intubation Techniques
- Neonatal Health and Biochemistry
- Climate Change and Health Impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Fatty Acid Research and Health
- Disaster Response and Management
- Esophageal and GI Pathology
Kobe University
2006-2025
Kagawa Prefectural Central Hospital
2023
European Society for Clinical Nutrition and Metabolism
2023
Hyogo Medical University
2013-2022
Weatherford College
2020-2022
Kobe Institute Of Computing
2020-2021
Tokushima University Hospital
2021
Tokushima University
2021
Kobe University Hospital
2020-2021
Suzuki (Japan)
2020
Abstract Introduction Abnormal body temperatures (T b ) are frequently seen in patients with severe sepsis. However, the relationship between T abnormalities and severity of disease is not clear. This study investigated impact on outcomes Methods We enrolled 624 sepsis grouped them into 6 categories according to their at time enrollment. The temperature (≤35.5°C, 35.6–36.5°C, 36.6–37.5°C, 37.6–38.5°C, 38.6–39.5°C, ≥39.6°C) were based data Acute Physiology Chronic Health Evaluation II (APACHE...
Abstract Introduction To validate the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) scoring system in patients with severe sepsis, we conducted a multicenter, prospective study at 15 critical care centers tertiary hospitals. Methods This included 624 sepsis patients. JAAM DIC was scored on day of diagnosis (day 1) and 4. Scores disease severity organ dysfunction were also evaluated. Results The prevalence 46.8% (292/624), 21% according to...
Sepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the incidence, clinical characteristics, evolving management sepsis important. Thus, this study aimed to evaluate management, outcomes patients with severe Japan.This cohort Focused Outcomes Research Emergency Care Acute Respiratory Distress Syndrome, Sepsis, Trauma (FORECAST) study, which was multicenter, prospective conducted at 59 intensive care units (ICUs) from January 2016...
Abstract Circulating lipopolysaccharide (LPS) concentrations are often elevated in patients with sepsis or various endogenous diseases related to bacterial translocation from the gut. Systemic inflammatory responses induced by endotoxemia induce severe involuntary loss of skeletal muscle, termed muscle wasting, which adversely affects survival and functional outcomes these patients. Currently, no drugs available for treatment endotoxemia-induced wasting. Here, we tested effects TAK-242, a...
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set clinical practice guidelines sepsis septic shock created jointly by the Society Intensive Care Medicine Association Acute Medicine, was first released in February 2017 published Journal JSICM, [2017; Volume 24 (supplement 2)] https://doi.org/10.3918/jsicm.24S0001 28, 1)] http://onlinelibrary.wiley.com/doi/10.1002/jja2.2017.28.issue-S1/issuetoc . This abridged...
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), a Japanese-specific set clinical practice guidelines sepsis septic shock created as revised from J-SSCG 2016 jointly by the Society Intensive Care Medicine Association Acute Medicine, was first released in September published February 2021. An English-language version these based on contents original Japanese-language version. purpose this guideline is to assist medical staff making...
This is a guideline for the management of sepsis, developed by Sepsis Registry Committee The Japanese Society Intensive Care Medicine (JSICM) launched in March 2007. was on basis evidence-based medicine and focuses unique treatments Japan that have not been included Surviving Campaign guidelines (SSCG), as well are viewed differently Western countries. Although methods this conform to 2008 SSCG, literature results Survey, which performed twice intensive care units (ICUs) registered with...
Accurate and early identification of infection sites might help to drive crucial decisions regarding the treatment sepsis. We aimed determine clinical etiological features according among patients with severe sepsis in Japan.This secondary analysis a multicenter, prospective cohort study included 59 intensive care units (ICU) proceeded between January 2016 March 2017. The comprised 1184 adults (≥ 16 years) who were admitted an ICU septic shock diagnosed sepsis-2 criteria. Sites by physicians...
Background and Purpose The Japanese Clinical Practice Guidelines for Management of Sepsis Septic Shock 2016 (J‐ SSCG 2016), a Japanese‐specific set clinical practice guidelines sepsis septic shock created jointly by the Society Intensive Care Medicine Association Acute Medicine, was first released in February 2017 Japanese. An English‐language version these based on contents original Japanese‐language version. Methods Members were selected organized into 19 committee members 52 working group...
Abstract Background Elderly patients have a blunted host response, which may influence vital signs and clinical outcomes of sepsis. This study was aimed to investigate whether the associations between mortality are different in elderly non-elderly with Methods retrospective observational study. A Japanese multicenter sepsis cohort (FORECAST, n = 1148) used for discovery analyses. Significant results were tested replication using two validation cohorts (JAAMSR, Japan, 624; SPH, Canada, 1004)....
Objective Autophagy is the regulated catabolic process for recycling damaged or unnecessary organelles, which plays crucial roles in cell survival during nutrient deficiency, and innate immune defense against pathogenic microorganisms. has been also reported to be involved various conditions including inflammatory diseases. IRGM (human immunity-related GTPase) an important function eliminating Mycobacterium tuberculosis from host cells via autophagy. We examined association between genetic...
Abstract Background Time to antibiotic administration is a key element in sepsis care; however, it difficult implement care bundles. Additionally, different from other emergent conditions including acute coronary syndrome, stroke, or trauma. We aimed describe the association between time and outcomes patients with severe septic shock Japan. Methods This prospective observational study enrolled 1184 adult diagnosed based on Sepsis-2 criteria admitted 59 intensive units (ICUs) Japan January 1,...
Sepsis-associated encephalopathy (SAE) increases not only morbidity and mortality but has been associated with long-lasting mental impairment after hospital discharge in septic patients. Recently, studies have shown that these impairments are caused by infection-induced neuroinflammation. However, the role of T cells pathogenesis SAE remains unclear. Thus, this study, we aimed to clarify how immune cells, especially influence development recovery disorders. In cecal slurry (CS)-induced mouse...
Antimicrobial stewardship teams (ASTs) have been well-accepted in recent years; however, their clinical outcomes not fully investigated urological patients. The purpose of this study was to evaluate the intervention via a retrospective review patients, as discussed AST meetings, who were treated with broad-spectrum antibiotics between 2014 and 2018 at Department Urology, Kobe University Hospital Japan. Interventions meetings for patients identified by pharmacists having received...
Diagnosing sepsis remains difficult because it is not a single disease but syndrome with various pathogen- and host factor-associated symptoms. Sepsis-3 was established to improve risk stratification among patients infection based on organ failures, has been still controversial compared previous definitions. Therefore, we aimed describe characteristics of who met sepsis-2 (severe sepsis) sepsis-3 definitions.This multicenter, prospective cohort study conducted by 22 intensive care units...
Background Dysglycemia is frequently observed in patients with sepsis. However, the relationship between dysglycemia and outcome inconsistent. We evaluate clinical characteristics, glycemic abnormalities, initial glucose level mortality Methods This a retrospective sub-analysis of multicenter, prospective cohort study. Adult severe sepsis (Sepsis-2) were divided into groups based on blood categories (<70 (hypoglycemia), 70–139, 140–179, ≥180 mg/dL), according to admission values. In-hospital...
<h2>Abstract</h2><h3>Background</h3> There is no one-size-fits-all empiric antimicrobial therapy for sepsis because the pathogens vary according to site of infection and have changed over time. Therefore, updating knowledge on spectrum necessary rapid administration appropriate antimicrobials. <h3>Objective</h3> The aim this study was elucidate current its variation by in sepsis. <h3>Methods</h3> This a prospective nationwide cohort consecutive adult patients with 59 intensive care units...