A5016442340- Physics of Superconductivity and Magnetism
- Sarcoma Diagnosis and Treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- Protein Interaction Studies and Fluorescence Analysis
- Magnetic and transport properties of perovskites and related materials
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Magnetic properties of thin films
- Cardiac tumors and thrombi
- Electromagnetic Simulation and Numerical Methods
- Iron-based superconductors research
- Electromagnetic Scattering and Analysis
- Cancer Genomics and Diagnostics
- Numerical methods in engineering
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Vascular Tumors and Angiosarcomas
- Tracheal and airway disorders
- Immunotherapy and Immune Responses
- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
- Thin-Film Transistor Technologies
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
Wellcome Sanger Institute
2019-2025
Osaka International Cancer Institute
2022-2025
Yokosuka Kyosai Hospital
2011-2024
Kanazawa Medical University Hospital
2020-2023
Tokyo Medical University
2017-2022
Hiroshima General Hospital
2018-2022
Osaka Prefectural Medical Center
2021
Nihon University
2020-2021
Tokyo Medical Examiner's Office
2021
Kyoto University
1999-2020
Abstract DNA is subject to continual damage, leaving each cell with thousands of individual lesions at any given moment 1–3 . The efficiency repair means that most known classes lesion have a half-life minutes hours 3,4 , but the extent which damage can persist for longer durations remains unknown. Here, using high-resolution phylogenetic trees from 89 donors, we identified mutations arising 818 persisted across multiple cycles in normal human stem cells blood, liver and bronchial epithelium...
The electromagnetic (EM) enhancement in surface-enhanced resonance Raman scattering (SERRS) is quantitatively evaluated for rhodamine molecules adsorbed on Ag nanostructures. Polarization dependence of the plasma (plasmon resonance) and SERRS spectra from single isolated nanostructures was to determine one-to-one relationship between optical anisotropy resonance, that SERRS, morphology Experimental observations were compared with finite-difference time-domain calculations EM field induced by...
Evidence of ``twofold'' electromagnetic (EM) enhancement in surface-enhanced resonance Raman scattering (SERRS) that exhibits a SERRS factor up to ${10}^{14}$ has been analyzed by comparing spectra and plasmon Rayleigh spectra. We identified spectral variations are induced selective bands whose maxima close maxima. The correlation between the energy demonstrated second EM as result coupling photons plasmons.
We have observed cosmic-ray electrons from 10 GeV to 800 by a long duration balloon flight using Polar Patrol Balloon (PPB) in Antarctica. The observation was carried out for 13 days at an average altitude of 35 km January 2004. detector is imaging calorimeter composed scintillating-fiber belts and plastic scintillators inserted between lead plates with 9 radiation lengths. performance the has been confirmed CERN-SPS beam test also investigated Monte-Carlo simulations. New telemetry system...
We analyze blinking in surface enhanced resonance Raman scattering (SERRS) and fluorescence (SEF) of rhodamine 6G molecules as intensity spectral instability by electromagnetic (EM) mechanism. find that irradiation intense NIR laser pulses induces SERRS SEF. Thanks to the finding, we systematically SEF from stable unstable using single Ag nanoparticle (NP) dimers. The analysis reveals two physical insights into follows. (1) is inversely proportional enhancement factors decay rate molecules....
ATF1, CREB1, and CREM constitute the CREB family of transcription factors. The genes encoding these factors are involved in gene fusion events human tumors. EWSR1-ATF1 EWSR1-CREB1 2 most characterized fusions, whereas EWSR1-CREM has been less studied. To better understand phenotypic spectrum mesenchymal tumors associated with fusion, we investigated archival cases using fluorescence situ hybridization and/or RNA sequencing. Among 33 clear cell sarcomas soft tissue tested, found 1 specimen, a...
NK3 homeobox 1 (NKX3-1) is widely accepted as a highly sensitive and specific marker for prostatic adenocarcinoma. Prompted by published transcriptome data showing upregulation of NKX3-1 mRNA expression in EWSR1-NFATC2 sarcoma, we explored the utility immunohistochemistry sarcoma diagnosis. We applied to 11 sarcomas 168 mimics using whole tissue sections. All consisted uniform small round or ovoid cells, all except at least focally typical growth pattern nests, cords, trabeculae within...
Fast multipole method (FMM) has been developed as a technique to reduce the computational cost and memory requirements in solving large-scale problems. This paper discusses an application of FMM three-dimensional boundary integral equation for elastostatic crack The many problems is discretized with Galerkin's method. resulting algebraic solved generalized minimum residual (GMRES). numerical results show that more efficient than conventional methods when number unknowns about 1200 and,...
Aldo-keto reductase family 1, member B10 (AKR1B10), an enzyme that converts retinals into retinols is known to detect in non–small cell lung carcinoma (squamous cell- and adeno-carcinomas), but barely expressed normal tissues. Since these types of occur frequently the uterus (like lung), AKR1B10 may also be overexpressed two major uterine cancer, cervical cancer (CC), endometrial (EMC). The objective this study investigate expression analyze its clinical significance. In samples from...
We examined an electromagnetic (EM) theory of surface-enhanced resonance Raman scattering (SERRS) using single Ag nanoaggregates. The SERRS-EM is characterized by twofold EM enhancement induced the coupling plasmon with both excitation and emission plus fluorescence. total cross-section spectra enhanced fluorescence were calculated following parameters: spectrum factor resonance, overlapped fluorescence, wavelengths. calculations well agreed experimental spectra, thus providing strong...
In the current work, we report on selective detection of HbA1c, a marker for glycemic control in diabetic patients, using surface enhanced resonance raman spectroscopy (SERRS). We found characteristic band around 770-830 cm(-1) SERRS spectrum HbA1c which was not present HbA. To examine contribution glucosyl moiety to investigated spectra nonenzymatically glycosylated that spectral features are essentially identical both and Furthermore, addition HbA into colloidal solution silver...
Giant cell tumor of bone typically involves the epiphysis long bones skeletally mature patients. It is genetically characterized by highly recurrent and specific mutations H3F3A gene, which encodes histone H3.3. The most common mutation G34W can readily be detected a recently developed mutation-specific antibody. rarely transforms to sarcoma (malignant giant bone), has not been in detail. We studied seven clinicopathologically defined malignant tumors, as well two H3F3A-mutant sarcomas...
This article reports the designed preparation of two different kinds novel porous metal nanostructured films, namely, an ordered macroporous Au/Ag film and hollow film. Different from previous reports, presently proposed method can be conveniently used to control structures by simply varying experimental conditions. The morphology these films has been characterized scanning electron microscopy (SEM), their performance as surface-enhanced Raman scattering (SERS) substrates evaluated using...
We labeled the living yeast cell surface (Saccharomyces cerevisiae strain W303-1A) by silver nanoparticles which can form nanoaggregates and found to show enhanced Raman scattering (SERS) activity. Blinking of SERS its polarization dependence reveal that signals are from amplified electromagnetic field at nanometric Ag gaps with single or a few molecules sensitivity. tentatively assigned spectra wall mannoproteins. Nanoaggregate-by-nanoaggregate variations temporal fluctuations discussed in...
Abstract Purpose To comprehensively summarize the magnetic resonance imaging (MRI) features of angiosarcomas presenting as Stewart-Treves syndrome (STS) through a retrospective case series and systematic review previous publications. Materials methods We identified five patients with STS from our institutional database 25 15 publications systemic review. reviewed MR 30 STS, including males females mean age 59.5 years. Results The tumors most commonly involved both cutis subcutis (17/25,...