A5046125043- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Lymphoma Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- MRI in cancer diagnosis
- Cerebrospinal fluid and hydrocephalus
- Lung Cancer Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
- Cancer, Hypoxia, and Metabolism
- Radioactive Decay and Measurement Techniques
- Advanced Neuroimaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Boron Compounds in Chemistry
- Digital Radiography and Breast Imaging
- Radiation Detection and Scintillator Technologies
- Esophageal Cancer Research and Treatment
- Medical Imaging and Pathology Studies
Kindai University
2016-2025
Kindai University Hospital
2011-2024
Tokyo Metropolitan Institute of Gerontology
2023
Fukushima Medical University
2023
Fujita Health University Hospital
2023
Nagoya University Hospital
2023
Kitasato University
2023
Nippon Medical School
2023
Osaka University
2013-2021
Boron neutron capture therapy (BNCT) is a molecular radiation treatment based on the (10)B (n, α) (7)Li nuclear reaction in cancer cells, which delivery of by 4-borono-phenylalanine conjugated with fructose (BPA-fr) to cells critical importance. The PET tracer 4-borono-2-(18) F-fluoro-phenylalanine (FBPA) has been used predict accumulation BPA-fr before BNCT. However, because difference chemical structure between and FBPA dose administered (therapeutic dose) (tracer dose), predictive value...
Abstract Purpose To comprehensively summarize the magnetic resonance imaging (MRI) features of angiosarcomas presenting as Stewart-Treves syndrome (STS) through a retrospective case series and systematic review previous publications. Materials methods We identified five patients with STS from our institutional database 25 15 publications systemic review. reviewed MR 30 STS, including males females mean age 59.5 years. Results The tumors most commonly involved both cutis subcutis (17/25,...
Background: In clinical practice, equivocal findings are inevitable in visual interpretation of whether amyloid positron emission tomography (PET) is positive or negative. It therefore necessary to establish a more objective quantitative evaluation method for determining the indication disease-modifying drugs currently under development. Aims: We aimed determine cutoffs positivity analysis 18 F-flutemetamol PET patients with cognitive impairment and suspected Alzheimer's disease (AD). also...
PET with <sup>15</sup>O gas has been used for the quantitative measurement of cerebral blood flow (CBF), metabolic rate oxygen (CMRO<sub>2</sub>), extraction fraction (OEF), and volume (CBV) in humans. However, several technical difficulties limit its use experiments on small animals. Herein, we describe application steady-state inhalation method normal anesthetized rats. <b>Methods:</b> Eight male Sprague–Dawley rats (mean body weight ± SD, 268 14 g) under anesthesia were investigated by...
Abstract Background The purpose of this study was to quantitatively evaluate the tumor accumulation and heterogeneity 111 In-ibritumomab tiuxetan (Zevalin®) 18 F-fluoro-deoxyglucose (FDG) compare them response in B-cell non-Hodgkin’s lymphoma patients receiving 90 Y-ibritumomab therapy. Methods Sixteen with histologically confirmed who underwent therapy along single-photon emission computerized tomography (SPECT)/CT FDG positron (PET)/CT were enrolled retrospective study. On pretherapeutic...
This study evaluated the physical performance of a positron emission tomography (PET) system dedicated to head and breast according National Electrical Manufacturers Association (NEMA) NU2-2012 standard.The spatial resolution, sensitivity, scatter fraction, count rate characteristics, corrections for losses randoms, image quality were determined. All measurements performed NEMA acquisition protocols, but was assessed using brain-sized phantom. Furthermore, scans three-dimensional (3D)...
The purpose of this study was to establish a practical method estimate the absolute boron concentrations in tissues based on standardized uptake values (SUVs) after administration 4-borono-phenylalanine (BPA) using 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) PET.Rat xenograft models C6 glioma (n = 7, body weight 241 ± 28.0 g) were used for study. PET performed 60 min intravenous injection 18F-FBPA (30.5 0.7 MBq). After scanning, BPA-fructose (167.3 18.65 mg/kg) administered by slow same...
Abstract Tungsten functional paper ( TFP ), which contains 80% tungsten by weight, has radiation‐shielding properties. We investigated the use of for protection operators during interventional or therapeutic angiography. The air kerma rate scattered radiation from a simulated patient was measured, with and without , using water‐equivalent phantom fixed C‐arm fluoroscopy. Measurements were taken at level operator's eye, chest, waist, knee, variable number sheets used shielding. A Monte Carlo...
Deep learning (DL) has recently attracted attention for data processing in positron emission tomography (PET). Attenuation correction (AC) without computed (CT) is one of the interests. Here, we present, to our knowledge, first attempt generate an attenuation map human head via Sim2Real DL-based tissue composition estimation from model training using only simulated PET dataset. The DL accepts a two-dimensional non-attenuation-corrected image as input and outputs four-channel...
To clarify the change in fluorodeoxyglucose (FDG) uptake by bone marrow over time after administration of granulocyte colony-stimulating factor (G-CSF), we evaluated correlation between interval from last day G-CSF to positron emission tomography/computed tomography (PET/CT) study and spinal accumulation patients with non-Hodgkin's lymphoma.A total 127 confirmed lymphoma who underwent FDG PET within 60 days were retrospectively reviewed. Thirty age-matched sex-matched healthy controls also...
We acquired brain 18F-FDG and 18F-flutemetamol PET images using a time-of-flight system dedicated to the head (dhPET) conventional whole-body PET/CT (wbPET) evaluated clinical superiority of dhPET over wbPET. Methods: There were 18 subjects for study 17 study. first obtained wbPET, followed by dhPET. Images wbPET compared visual inspection, voxelwise analysis, SUV ratio (SUVR). Results: All judged as visually better than those The analysis demonstrated that accumulations in cerebellum,...
Decreased cerebral glucose metabolism has been reported in idiopathic normal pressure hydrocephalus (iNPH). However, the timing of appearance preclinical stage iNPH remains unknown. Herein, we evaluated changes regional with respect to characteristic morphologic features iNPH.We performed a cross-sectional study > 2000 elderly patients who received whole body 18F-fluorodeoxyglucose-positron emission tomography/computed tomography scanning and recruited subjects clinical iNPH. We included 12...
Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) findings are often reported as characteristic radiological features of idiopathic normal pressure (iNPH). However, the process development DESH remains unclear. The aim present study was to determine dynamic deforming and pathophysiology iNPH. All patients >50 years age who underwent whole body FDG-PET/CT scanning at Kindai University Hospital between May 2017 April 2018 were included in this retrospective study, their brain...
18F-misonidazole positron emission tomography (FMISO PET)/computed (CT) obtained before and during radiotherapy (RT) was analyzed as to whether it could predict clinical outcome.Twenty-two patients were included. FMISO PET/ CT performed twice RT at a dose of approximately 20 Gy/10 fractions. maximum standardized uptake values (SUVmax), the tumor-to-muscle ratios (T/M), hypoxic volume (HV) in gross target volumes measured.Of 22 tumors, 18 had areas (SUVmax ≥1.60) RT. SUVmax, T/M, HV on first...
The performances of photomultiplier tube (PMT)-based dedicated breast positron emission tomography (PET) and silicon (SiPM)-based time-of-flight (TOF) PET, which is applicable not only to imaging but also head imaging, were compared using a phantom study. A cylindrical containing four spheres (3–10 mm in diameter) filled with 18F-FDG at two signal-to-background ratios (SBRs), 4:1 8:1, was scanned. images, reconstructed three-dimensional list-mode dynamic row-action maximum likelihood...
The aim of this study was to investigate low-dose kilovoltage cone-beam CT (kV-CBCT) for image-guided radiotherapy, with a particular focus on the accuracy image registration protocols.Imaging doses were measured NOMEX semiconductor detector positioned at front head, thorax, and pelvis human body phantoms while kV-CBCT scans acquired different tube currents. Aspects quality (spatial resolution, noise, uniformity, contrast, geometric distortion, Hounsfield unit sensitivity) using bone soft...