A5058534270- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Iron Metabolism and Disorders
- MRI in cancer diagnosis
- Family Caregiving in Mental Illness
- Medical Imaging Techniques and Applications
- Complement system in diseases
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Hormonal Regulation and Hypertension
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Blood groups and transfusion
- Psychiatric care and mental health services
- Mental Health Treatment and Access
- Schizophrenia research and treatment
- Intracranial Aneurysms: Treatment and Complications
- Inhalation and Respiratory Drug Delivery
- Thermoregulation and physiological responses
- Adrenal and Paraganglionic Tumors
Alexion Pharmaceuticals (United States)
2024
AstraZeneca (United States)
2024
National Center of Neurology and Psychiatry
2010-2022
Imagerie et Cerveau
2019
Imaging Center
2019
Alexion Pharma (Switzerland)
2014
University of Shizuoka
2011
Pfizer (United States)
2004-2010
New York Proton Center
2010
The University of Tokyo
2010
The aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database healthy controls from the common systems available in Japan. This study included 510 sets data 256 (116 men and 140 women; age range, 30–83 years) acquired eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only using Chang method (ChangACNOSC) X-ray CT (CTACNOSC), both (ChangACSC) (CTACSC). These images analyzed Southampton method. outcome measure...
Background: In clinical practice, equivocal findings are inevitable in visual interpretation of whether amyloid positron emission tomography (PET) is positive or negative. It therefore necessary to establish a more objective quantitative evaluation method for determining the indication disease-modifying drugs currently under development. Aims: We aimed determine cutoffs positivity analysis 18 F-flutemetamol PET patients with cognitive impairment and suspected Alzheimer's disease (AD). also...
Abstract Introduction Molecular imaging and selective hippocampal subfield atrophy are a focus of recent Alzheimer's disease (AD) research. Here, we investigated correlations between molecular subfields in early AD. Methods We 18 patients with AD healthy control subjects using 11 C‐Pittsburgh compound‐B (PIB) positron emission tomography (PET) F‐THK5351 PET automatic segmentation high‐resolution T2‐weighted magnetic resonance imaging. The images were normalized underwent voxelwise regression...
Approximately 40% of Japanese patients with essential hypertension, including low‐renin are inadequately managed. Low‐renin hypertension generally responds poorly to angiotensin‐converting enzyme inhibitors and angiotensin‐receptor blockers, but may respond more optimally diuretics, calcium channel aldosterone blockers. This multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group, dose‐ranging study evaluated the efficacy safety selective blocker eplerenone in 193...
OBJECTIVE—The purpose of this study was to evaluate the 2-year pulmonary safety inhaled human insulin (Exubera [EXU]) in 635 nonsmoking adults with type 2 diabetes. RESEARCH DESIGN AND METHODS—Patients were randomly assigned receive prandial EXU or subcutaneous (regular short-acting) plus basal (intermediate- long-acting) insulin. The primary end points annual rate decline forced expiratory volume 1 s (FEV1) and carbon monoxide diffusing capacity (DLCO). RESULTS—Small differences FEV1...
Ito J, Oshima I, Nishio M, Sono T, Suzuki Y, Horiuchi K, Niekawa N, Ogawa Setoya Hisanaga F, Kouda Tsukada K. The effect of Assertive Community Treatment in Japan. Objective: aim this study was to evaluate the effects (ACT) program a Japanese mental health service setting. Method: This randomized controlled trial. ACT intervention condition (n = 59), and usual hospital-based rehabilitation control 59). Outcome indicators include in-patient days, psychiatric symptoms, social functioning,...
Cognitive assessments and neuroimaging are routinely combined in clinical practice to diagnose dementia represented by Alzheimer's disease (AD). The Montreal Assessment (MoCA) is reported be more suitable than the Mini-Mental State Examination (MMSE) for screening mild cognitive impairment (MCI) AD. On other hand, attention subfield volumes of medial temporal lobe has recently been considered important differential diagnosis early detection aim this study was uncover which specific...
Abstract Introduction Alzheimer's disease (AD) is characterized by accumulation of extracellular amyloid‐β and intracellular tau neurofibrillary tangles. The recent advent positron emission tomography (PET) has enabled in vivo assessment pathology. aim this study was to explore whether deposition influences the structural connectivity amyloid‐negative amyloid‐positive groups, further difference between groups. Methods We investigated 18 patients with amnestic mild cognitive impairment/mild...
Voxel-based specific regional analysis system for Alzheimer's disease (VSRAD) software is widely used in clinical practice (AD). The existing VSRAD based on the normal database with 1.5-tesla MRI scans (VSRAD-1.5T), and its utility patients have undergone 3-tesla still controversial. We recruited 19 early AD 28 healthy controls who had at our institute (Cohort 1). also data of 30 13 from Japanese Disease Neuroimaging Initiative 2). created a new 65 subjects' (VSRAD-3T), compared...
The recent advent of tau-specific positron emission tomography (PET) has enabled in vivo assessment tau pathology Alzheimer's disease (AD). However, because PET scanners have limited spatial resolution, the measured signals small brain structures or atrophied areas are underestimated by partial volume effects. aim this study was to determine whether correction (PVC) improves precision measures deposits early AD. We investigated 18 patients with amyloid-positive AD and 36 amyloid-negative...
We introduced a promoter trap vector carrying neo gene as selectable marker into F9 cells and established several cell lines in which the expression of is under control an endogenous host that active only undifferentiated cells. Using one these lines, G19, we isolated integrated construct its flanking sequences by plasmid rescue method, identified contributes to gene, named it Zfp-57 gene. Two different transcripts (1.8 3.2 kilobases) were cells, levels decreased significantly within short...
Hippocampal subfield volumetry should be more useful than whole hippocampal (WH) for diagnosing Alzheimer disease (AD). This study sought to confirm this.We investigated cognitively normal (CN) participants and patients with mild cognitive impairment (MCI) or AD using high-resolution T2-weighted 3-dimensional T1-weighted magnetic resonance imaging. Using medial temporal subregion volumetry, we discriminative power MCI versus CN.We recruited 30 CN participants, amnestic patients, 49 between...
Although the development of effective therapeutic drugs and radical treatment options for dementia Alzheimer's disease (AD) remains urgent, progress in recent clinical trials AD has been less than adequate. In order to advance trials, it is necessary establish more efficient methods recruitment. Japan, there are registration systems stratified by mild cognitive impairment preclinical stages early advanced stage dementia, but no system healthy individuals yet. Therefore, present study, we...
Although neurofibrillary tangles (NFTs) mainly accumulate in the medial temporal lobe with human aging, only a few imaging studies have investigated correlations between NFT accumulation and gray matter (GM) volume cognitively normal older adults. Here, we 18F-THK5351 GM at voxel level. We recruited 47 amyloid-negative, normal, adults (65.0 ± 7.9 years, 26 women), who underwent structural magnetic resonance imaging, 11C-Pittsburgh compound-B PET scans, neuropsychological assessment. The...
A series of vinylimidazoles containing a hetero atom such as sulfur or oxygen at beta-position the vinyl group was prepared and antifungal activities were tested. It found that sulfur-substituted derivatives (E)-1-[2-(methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole (5a-5) (E)-1-[1-[2-(hexyloxy)phenyl]-2-(methylthio)ethenyl]-1H-imidazole (5a-6) showed excellent against dermatophytes yeast cells. The stereochemistry hydrochloride salt 5a-5 determined by X-ray crystallography....
With the rapid aging of global population, cognitive decline and dementia pose large-scale healthcare socioeconomic burdens. Strategies to address these burdens are urgently needed, particularly for due Alzheimer's disease (AD). Such strategies include development modifying therapies (DMT) AD but must also incorporate a preventive approach reducing risk factors. Over past 10 years, DMT clinical trials have been largely unsuccessful, partly difficulty in recruiting early stage patients...