A5081327067- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Functional Brain Connectivity Studies
- Spinal Dysraphism and Malformations
- Alzheimer's disease research and treatments
- Fetal and Pediatric Neurological Disorders
- Advanced MRI Techniques and Applications
- Urologic and reproductive health conditions
- Bone and Joint Diseases
- Maternal and fetal healthcare
- Neuroendocrine Tumor Research Advances
- Ultrasound Imaging and Elastography
- Meningioma and schwannoma management
- Prenatal Screening and Diagnostics
- Ovarian cancer diagnosis and treatment
- Pancreatitis Pathology and Treatment
- Cardiac Arrhythmias and Treatments
- Teratomas and Epidermoid Cysts
- Cardiomyopathy and Myosin Studies
- Urological Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Gestational Trophoblastic Disease Studies
- Pancreatic and Hepatic Oncology Research
- Pituitary Gland Disorders and Treatments
- Invertebrate Immune Response Mechanisms
The University of Tokyo
1987-2025
Juntendo University
2022-2025
National Center of Neurology and Psychiatry
2021-2024
Juntendo University Hospital
2024
University of Michigan–Ann Arbor
2023
NTT Medical Center
2019-2021
Suzuki (Japan)
2021
Weatherford College
2021
Muroran Institute of Technology
1995
Tokyo University of Agriculture
1995
Amyloid-β (Aβ) and tau protein accumulation in the brain is thought to be one of causes Alzheimer's disease (AD). Recent study found that glymphatic system was waste drainage promoting elimination Aβ protein.We evaluated relationships between activity deposition.Subjects were 21 patients with AD 36 healthy subjects who underwent diffusion tensor imaging (DTI) scan positron emission tomography (PET) using tracer: 11C-PiB tau/inflammatory 18F-THK5351. We computed image analysis along...
The Alzheimer’s disease (AD) continuum is characterized by amyloid and tau protein deposition, which partly attributable to the dysfunction of brain clearance system. However, specific phase in AD wherein aberrant present remains unclear. This study aimed assess noninvasive magnetic resonance imaging (MRI) indices related functions, such as choroid plexus volume (CPV), lateral ventricular (LVV), index diffusivity along perivascular space (ALPS index), across spectrum. CPV, LVV, ALPS beta...
Background: Cortical neurodegenerative processes may precede the emergence of disease symptoms in patients with Alzheimer’s (AD) by many years. No study has evaluated free water AD using gray matter-based spatial statistics. Objective: The aim this was to explore cortical microstructural changes within matter imaging Methods: Seventy-one participants underwent multi-shell diffusion magnetic resonance imaging, 11C-Pittsburgh compound B positron emission tomography, and neuropsychological...
Characterization of brain networks by diffusion MRI (dMRI) has rapidly evolved, and there are ongoing movements toward data sharing multi-center studies. To extract meaningful information from data, methods to correct for the bias caused scanner differences, that is, harmonization, urgently needed. In this work, we report cross-scanner differences in structural network analyses using nine traveling subjects (four males five females, 21-49 years-old) who underwent scanning four 3T scanners...
Recent developments in image analysis have enabled an individual's brain network to be evaluated and age predicted from gray matter images. Our study aimed investigate the effects of sex on single-subject networks using a large sample healthy participants. We recruited 812 individuals (59.3 ± 14.0 years, 407 females, 405 males) who underwent three-dimensional T1-weighted magnetic resonance imaging. Similarity-based were constructed, following properties calculated: normalized clustering,...
Tau protein accumulation in the brain is thought to be one of causes Alzheimer’s disease (AD). Recent studies found that choroid plexus (CP) has a role β-amyloid and tau clearance brain. We evaluated relationships between CP volume ß-amyloid depositions. Participants were 20 patients with AD 35 healthy subjects who underwent MRI PET scanning using tracer 11 C-PiB tau/inflammatory 18 F-THK5351. computed estimated protein/inflammatory deposition by Spearman’s correlation test. The was...
ABSTRACT Thermodynamic properties in differential scanning calorimetry (DSC) and changes viscoelasticity upon heating of myosins from white croaker, Alaska pollock, rabbit fast muscles were investigated relation to their thermal gel formation abilities. pollock myosin unfolded a wide temperature range 19 69°C as revealed by DSC, whereas very narrow 32 56°C. Thermal unfolding croaker occurred an intermediate 30 60°C. Viscoelastic determined storage modulus, G′, loss G″, reflected differences...
Comprehensive in silico studies, based on the total fugu genome database, which was first to appear fish, revealed that torafugu Takifugu rubripes contains 20 sarcomeric myosin heavy chain (MYH) genes (MYH genes) (Ikeda et al., 2007). The present study undertaken identify MYH would be expressed adult muscles. In total, seven were found by screening cDNA clone libraries constructed from fast, slow and cardiac Three genes, fast-type MYH(M86-1), slow-type MYH(M8248) slow/cardiac-type MYH(M880),...
Tau protein accumulation in the brain is thought to be one of causes progressive supranuclear palsy (PSP). The glymphatic system was discovered a decade ago as waste drainage that promotes elimination amyloid-beta and tau protein. We here evaluated relationships between activity regional volumes PSP patients.Subjects were 24 patients with 42 healthy participants who underwent diffusion tensor imaging (DTI). computed image analysis along perivascular space (DTI‑ALPS) index proxy activity,...
Meningeal lesions can be caused by various conditions and pose diagnostic challenges. The authors review the anatomy of meninges in brain spinal cord to provide a better understanding localization extension these diseases summarize clinical imaging features that cause dural and/or leptomeningeal enhancing lesions. These include infectious meningitis (bacterial, tuberculous, viral, fungal), autoimmune (vasculitis, connective tissue diseases, meningoencephalitis, Vogt-Koyanagi-Harada disease,...
Journal Article Lower Activation Energy for Sliding of F-Actin on a Less Thermostable Isoform Carp Myosin Get access Shigeru Chaen, Chaen 1 *Department Physiology, School Medicine, Teikyo UniversityItabashi-ku, Tokyo 173 1To whom correspondence should be addressed. Tel.: +81-3-3964-1211 (Ext. 215), Fax: +81-3-5375-8789, E-mail: chaen@med.teikyo-u.ac.jp Search other works by this author on: Oxford Academic PubMed Google Scholar Misako Nakaya, Nakaya †Laboratory Aquatic Molecular Biology and...
This study aimed to characterize the clinical and imaging findings of intraductal oncocytic papillary neoplasm pancreas (IOPN-P) compared those mucinous adenoma/carcinoma (IPMA/IPMC).This multi-institutional retrospective reviewed clinical, imaging, pathological 21 patients with pathologically proven IOPN-P. Twenty-one computed tomography (CT) magnetic resonance seven 18F-fluorodeoxyglucose (FDG)-positron emission were performed before surgery. The following evaluated: preoperative blood...
<h3>BACKGROUND AND PURPOSE:</h3> Impaired glymphatic function has been suggested to be implicated in the pathophysiology of MS and aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorder. This study aimed investigate interstitial fluid dynamics brain patients with myelin oligodendrocyte glycoprotein antibody disorders (MOGAD), another demyelinating disorder, using a noninvasive imaging technique called diffusivity along perivascular space (ALPS) index. <h3>MATERIALS...