A5060641698- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Gastric Cancer Management and Outcomes
- Soft tissue tumor case studies
- Gastrointestinal disorders and treatments
- Medical Imaging and Pathology Studies
- Neurofibromatosis and Schwannoma Cases
- Cardiac tumors and thrombi
- Metastasis and carcinoma case studies
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Lung Cancer Treatments and Mutations
- Ion channel regulation and function
- Genetic factors in colorectal cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ovarian cancer diagnosis and treatment
- Congenital Diaphragmatic Hernia Studies
- Polyomavirus and related diseases
- Neuroscience and Neuropharmacology Research
- Nasolacrimal Duct Obstruction Treatments
- Vascular Tumors and Angiosarcomas
- HER2/EGFR in Cancer Research
Tokyo Medical University
2017-2025
NTT Medical Center
2014-2024
Tokyo Health Care University
2019-2020
Kanazawa University
2017
Gunma University
2008-2011
Toranomon Hospital
1999-2000
The University of Tokyo
1992-1999
Teikyo University
1996
Juntendo University Urayasu Hospital
1989
BACKGROUND It has been reported that the c-erbB-2 protooncogene is frequently amplified and overexpressed in many types of cancers, except sarcomas hematological malignancies. METHODS Expression ErbB-2 tumors 26 patients with conventional osteosarcoma was evaluated by immunoblotting. DNA from tissues expressed were analyzed Southern blot hybridization to examine gross rearrangement gene. The also surveyed for presence genetic mutation transmembrane domain polymerase chain...
Abstract Background Duodenal endoscopic submucosal dissection (ESD) remains technically challenging, with a high risk of severe adverse events. Because exposure the duodenal post-ESD mucosal defect to pancreatic juice and bile acid reportedly induces delayed perforation bleeding, we examined whether closure using an over-the-scope clip (OTSC) system was useful for preventing postoperative Methods From April 2016 February 2017, total 50 consecutive patients superficial non-ampullary...
Cerebellar Purkinje cells (PCs) express a large amount of the γ isoform protein kinase C (PKCγ) and modest level PKCα. The PKCγ is involved in pruning climbing fiber (CF) synapses from developing PCs, PKCα plays critical role long-term depression (LTD) at parallel (PF)-PC synapses. Moreover, PKC signaling PCs negatively modulates nonselective transient receptor potential cation channel type 3 (TRPC3), opening which elicits slow EPSCs PF-PC Autosomal dominant spinocerebellar ataxia 14 (SCA14)...
BACKGROUND The prognosis for patients with osteosarcoma has improved over the past 20 years, mainly due to developments in chemotherapy. Some proteins have been reported show drug resistance. Theoretically, overexpression of some these makes treatment difficult, leading poorer outcome. METHODS Specimens taken from conventional osteosarcomas extremity bones 60 younger than 30 years were used. In all cases, preoperative oncostatic chemotherapy was undertaken after biopsy. If available, biopsy...
<title>Abstract</title> Since the introduction of concept molecular classification, integrated diagnostics have become an essential tool, but this has led to problem high cost, and requirement a large amount effort reach diagnosis. In study, we investigated possibility performing diagnoses tumors using artificial intelligence (AI) analyze only hematoxylin-eosin (HE)-stained slides. About 80 features cell nuclei were analyzed, support vector machine model Random Forest algorithm determine...
Pulmonary pleomorphic carcinomas are rare malignant tumors, and no standard treatments have been established. We herein report the successful treatment of a patient with pulmonary carcinoma pembrolizumab. A 51-year-old man who was current smoker presented to our hospital due dyspnea hemosputum. Chest X-ray showed right-sided pneumothorax pleural effusion; chest tube drainage therefore performed. Computed tomography after cavitary nodule in right upper lobe hilar bilateral mediastinal...
A case of multiple small Intestinal stromal tumors (SIST) with skeinoid fibers the jejunum arising in a 50 year old male neurofibromatosis 1 (NF‐1) is reported. Seven jejunal wall were incidentally found and excised during an operation for abdominal retroperitoneal neuroflbromas. Histologlcally, composed uniform spindle‐shaped cells fascicular pattern, almost indistinguishable from histology leiomyoma. Periodic acid Schiff stain‐positive hyaline globules observed among tumor cells....
Background. Although epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are effective in patients with nonsmall cell lung cancer receptor (EGFR) mutation, EGFR-TKIs have a risk of inducing fatal interstitial disease (ILD). The selection chemotherapy based on the EGFR mutation status is recommended, however, frequency ILD and efficacy safety EGFR-TKI unknown. Methods. We retrospectively reviewed association pulmonary diseases. Based high-resolution computed tomography...
There are various mechanisms underlying the resistance of EGFR-mutant lung adenocarcinoma to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). We herein report a case pulmonary with EGFR mutation (exon 19 deletion and T790M) that acquired osimertinib treatment because transformation into small-cell carcinoma (SCLC). A 67-year-old ex-smoking woman was diagnosed left upper lobe clinical stage IIIA (cT2bN2M0). She treated chemoradiotherapy (cisplatin vinorelbine plus...
Perineural invasion (PNI) is one of the major pathological characteristics pancreatic ductal adeno-carcinoma (PDAC), which mediated by invading cancer cells into nerve cells. Herein, we identify overexpression Interleukin-13 Receptor alpha2 (IL-13Rα2) in PNI from 236 PDAC samples studying its expression at protein levels immunohistochemistry (IHC) and RNA level situ hybridization (ISH). We observe that ≥75% overexpressed IL-13Rα2 IHC ISH grade 2 3 tumors, while ≥64% stage II III tumors...
Abstract The δ2 glutamate receptor (GluRδ2) is expressed predominantly in cerebellar Purkinje cells. GluRδ2 knock‐out mice show impaired synaptogenesis and loss of long‐term depression (LTD) at parallel fiber/Purkinje cell synapses, persistent multiple climbing fiber (CF) innervation cells, resulting severe ataxia. To identify domains critical for function, we produced various deletion constructs. Using lentiviral vectors, those constructs were cells GluRδ2‐deficient postnatal day (P) 6 or...
Solitary pulmonary capillary hemangioma (SPCH) is a rare disease, first described about autopsy cases in 2000 and surgically resected 2006. To date, only 9 have been published English. Here, we report 7 original with surgery (median age, 54 y; 4 females, 2 never-smokers). All patients were asymptomatic, all nodules detected by computed tomography (CT). The median (range) size of nodule was 11 (8 to 16) mm. Six showed the part-solid appearance 1 pure ground-glass CT findings. growth speed...
Fibrous dysplasia and osteofibrous are both benign fibro‐osseous lesions of the bone. We retrospectively studied clinicopathological findings in 90 cases fibrous 17 dysplasia. In these cases, expression proliferating cell nuclear antigen (PCNA) presence argyrophilic nucleolar organizer regions (AgNOR), as well DNA ploidy, were examined. The bones affected by maxilla, femur frontal Osteofibrous occurred exclusively tibia or fibula. average age patients with (24.0 years) was higher than that...
Primary neuroendocrine carcinoma of the breast is a rare entity, comprising <1% carcinomas. Described here case 78-year-old woman who developed an invasive tumor in left measuring 2.0 cm x 1.5 1.2 cm. The was composed only endocrine elements part. It infiltrated nested fashion with no tubular formation. Intraductal components were present both inside and outside portion. Almost all cells consisting intraductal parts positive for synaptophysin neuron-specific enolase. According to World...
The aim of this study is to evaluate the degree and spectrum malignancy dermatofibrosarcoma protuberans (DFSP) in aspect proliferative activity, flow cytometric DNA analysis, p53 immunoreactivity. Twenty‐three tumors from 19 cases DFSP including three with fibrosarcomatous areas (DFSP‐FS) were studied comparison its allied fibrohistiocytic tumors; that is, dermatofibroma (DF; 46 cases), fibrosarcoma (FS; four malignant fibrous histiocytoma (MFH; 11 cases). MIB‐1 labeling index (LI) was...
A 69-year-old man presented with progressive paralysis of the right arm and leg a past history metastatic rectal cancer. Magnetic resonance imaging showed cystic mass lesion posterior to odontoid process. Under preoperative diagnosis intradural extramedullary tumor, partial transcondylectomy C1 hemilaminectomy were performed, cyst was removed through transdural approach, decompressing medulla oblongata cervical spinal cord. The histological juxtafacet (ganglion cyst). An atlantoaxial...