A5031316622- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Mental Health Research Topics
- Fetal and Pediatric Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Psychosomatic Disorders and Their Treatments
- Epilepsy research and treatment
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Cerebrospinal fluid and hydrocephalus
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Neurological Disease Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
National Center of Neurology and Psychiatry
2016-2025
University of Tsukuba
2009-2025
Teikyo University
2025
Tokyo Medical and Dental University
2025
University of Tsukuba Hospital
2009-2021
National Institute of Mental Health
2015-2016
Bando Chemical Industries (Japan)
2009-2011
National Institutes for Quantum Science and Technology
2006-2008
Tokyo Metropolitan Neurological Hospital
2008
Kyoto University
2008
Clinical and animal studies suggested that a medium-chain triglyceride (MCT)-based ketogenic diet provides an alternative energy substrate to the brain has neuroprotective effects, but clinical evidence is still scarce. Here we examined effect of MCT-based formula on cognitive function in patients with Alzheimer's disease (AD). The subjects were 20 Japanese mild-to-moderate AD (11 males, nine females, mean age 73.4 ± 6.0 years) who, separate days, underwent neurocognitive tests 120 min after...
This randomized, placebo-controlled, crossover, and double-blind trial aimed to examine the possible effects of four weeks L-theanine administration on stress-related symptoms cognitive functions in healthy adults. Participants were 30 individuals (nine men 21 women; age: 48.3 ± 11.9 years) who had no major psychiatric illness. (200 mg/day) or placebo tablets randomly blindly assigned for four-week administration. For symptoms, Self-rating Depression Scale, State-Trait Anxiety...
Background: Although the pathophysiology of bipolar disorder remains elusive, growing evidence suggests beneficial effects Bifidobacterium and Lactobacillus in gut microbiota on stress response depressive symptoms. In present study, we examined counts for association with serum cortisol levels. Methods: Bacterial fecal samples were 39 patients according to Diagnostic Statistical Manual Mental Disorders, 4th edn. 58 healthy controls using bacterial rRNA-targeted reverse...
Amyloid-β (Aβ) and tau protein accumulation in the brain is thought to be one of causes Alzheimer's disease (AD). Recent study found that glymphatic system was waste drainage promoting elimination Aβ protein.We evaluated relationships between activity deposition.Subjects were 21 patients with AD 36 healthy subjects who underwent diffusion tensor imaging (DTI) scan positron emission tomography (PET) using tracer: 11C-PiB tau/inflammatory 18F-THK5351. We computed image analysis along...
Abstract Aim We aimed to examine the gut permeability in patients with schizophrenia and its relevance symptoms, medication, cognitive functions, blood immune markers. Methods selected 22 (mean age: 37.9 ± 10.5 years) comprising 9 men 13 women. Furthermore, we included 86 healthy controls 43.5 11.0 41 45 All participants were biologically unrelated of Japanese descent. used Positive Negative Syndrome Scale (PANSS) Brief Assessment Cognition Schizophrenia (BACS) measure severity symptoms...
Objective l -theanine, an amino acid uniquely contained in green tea ( Camellia sinensis ), has been suggested to have various psychotropic effects. This study aimed examine whether -theanine is effective for patients with major depressive disorder (MDD) open-label clinical trial. Methods Subjects were 20 MDD (four males; mean age: 41.0±14.1 years, 16 females; 42.9±12.0 years). (250 mg/day) was added the current medication of each participant 8 weeks. Symptoms and cognitive functions...
Autism spectrum disorder often co-occurs with other psychiatric disorders. Although a high prevalence of autistic-like traits/symptoms has been identified in the pediatric population normal intelligence, there are no reports from adult population. This study examined whether is greater patients adult-onset disorders such as major depressive (MDD), bipolar disorder, or schizophrenia, and an association independent symptom severity. The subjects were 290 adults intelligence between 25 59 years...
Abstract Epilepsy is a diverse brain disorder, and the pathophysiology of its various forms comorbidities largely unknown. A recent machine learning method enables us to estimate an individual’s “brain-age” from MRI; this brain-age prediction expected as novel individual biomarker neuropsychiatric disorders. The aims study were for categories epilepsy evaluate clinical discrimination by (1) effect psychosis on temporal lobe (TLE), (2) psychogenic nonepileptic seizures (PNESs) MRI-negative...