A5079975902- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Genetic Neurodegenerative Diseases
- Cerebrospinal fluid and hydrocephalus
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Medical Imaging Techniques and Applications
- Muscle Physiology and Disorders
- Neurological diseases and metabolism
- Neurotransmitter Receptor Influence on Behavior
- Mitochondrial Function and Pathology
- MRI in cancer diagnosis
- Genetics and Neurodevelopmental Disorders
- Metabolism and Genetic Disorders
- Neurological and metabolic disorders
- Tuberous Sclerosis Complex Research
- RNA regulation and disease
National Center of Neurology and Psychiatry
2013-2025
University of Tsukuba
2024
Southern Tohoku General Hospital
2020-2022
Southern Research Institute
2020
Cyclotron (Netherlands)
2020
Amyloid-β (Aβ) and tau protein accumulation in the brain is thought to be one of causes Alzheimer's disease (AD). Recent study found that glymphatic system was waste drainage promoting elimination Aβ protein.We evaluated relationships between activity deposition.Subjects were 21 patients with AD 36 healthy subjects who underwent diffusion tensor imaging (DTI) scan positron emission tomography (PET) using tracer: 11C-PiB tau/inflammatory 18F-THK5351. We computed image analysis along...
Background: Cortical neurodegenerative processes may precede the emergence of disease symptoms in patients with Alzheimer’s (AD) by many years. No study has evaluated free water AD using gray matter-based spatial statistics. Objective: The aim this was to explore cortical microstructural changes within matter imaging Methods: Seventy-one participants underwent multi-shell diffusion magnetic resonance imaging, 11C-Pittsburgh compound B positron emission tomography, and neuropsychological...
Background: In clinical practice, equivocal findings are inevitable in visual interpretation of whether amyloid positron emission tomography (PET) is positive or negative. It therefore necessary to establish a more objective quantitative evaluation method for determining the indication disease-modifying drugs currently under development. Aims: We aimed determine cutoffs positivity analysis 18 F-flutemetamol PET patients with cognitive impairment and suspected Alzheimer's disease (AD). also...
Abstract Objective Amyloid positron emission tomography (PET) can reliably detect senile plaques and fluorinated ligands are approved for clinical use. However, the impact of amyloid PET imaging is still under investigation. The aim this study was to evaluate diagnostic utility in patient management using 18 F-florbetapir patients with cognitive impairment suspected Alzheimer’s disease (AD). We also aimed determine cutoffs positivity quantitative measures by investigating agreement between...
In multiple system atrophy with predominant parkinsonism (MSA-P), several voxel-based morphometry (VBM) studies have revealed gray matter loss; however, the white volume changes been rarely reported. We investigated of as well by VBM. A retrospective MRI study was performed in 20 patients MSA-P and 30 age-matched healthy controls. applied VBM statistical parametric mapping (SPM8) plus diffeomorphic anatomical registration through exponentiated Lie algebra (DARTEL) to explore regional all...
Abstract Background and Purpose Free‐water‐corrected diffusion tensor imaging (FW‐DTI), a new analysis method for MRI, can indicate neuroinflammation degeneration. There is increasing evidence of autoimmune etiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We used FW‐DTI conventional DTI to investigate microstructural brain changes related autoantibody titers patients with ME/CFS. Methods prospectively examined 58 consecutive right‐handed ME/CFS who underwent both MRI...
<h3>BACKGROUND AND PURPOSE:</h3> The transmantle sign is a characteristic MR imaging finding often seen in focal cortical dysplasia type IIb. typically hyperintense on T2WI and FLAIR hypointense T1WI. However, some cases, it shows T1 high signal. We evaluated the pathologic findings to identify causes of signal sign. <h3>MATERIALS METHODS:</h3> retrospectively reviewed preoperative data 141 consecutive patients with histologically proved dysplasia. selected 25 divided them into groups based...
Recent developments in image analysis have enabled an individual's brain network to be evaluated and age predicted from gray matter images. Our study aimed investigate the effects of sex on single-subject networks using a large sample healthy participants. We recruited 812 individuals (59.3 ± 14.0 years, 407 females, 405 males) who underwent three-dimensional T1-weighted magnetic resonance imaging. Similarity-based were constructed, following properties calculated: normalized clustering,...
Tau protein accumulation in the brain is thought to be one of causes Alzheimer’s disease (AD). Recent studies found that choroid plexus (CP) has a role β-amyloid and tau clearance brain. We evaluated relationships between CP volume ß-amyloid depositions. Participants were 20 patients with AD 35 healthy subjects who underwent MRI PET scanning using tracer 11 C-PiB tau/inflammatory 18 F-THK5351. computed estimated protein/inflammatory deposition by Spearman’s correlation test. The was...
Abnormal brain aging is suggested in epilepsy. Given the network dysfunction epilepsy, white matter tracts, which primarily interconnect regions, could be of special importance. We focused on diverse forms epilepsy and comorbid psychosis. obtained diffusion tensor imaging (DTI) data at 3 T-MRI 257 patients with 429 healthy subjects. The tract-based fractional anisotropy values subjects were used to build a brain-age prediction model, we calculated brain-predicted age difference (brain-PAD:...
Background Diffusional kurtosis imaging (DKI) and neurite orientation dispersion density (NODDI) metrics provide more specific information regarding pathological changes than diffusion tensor (DTI). Purpose To detect microstructural abnormalities in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS) patients by using DKI NODDI metrics. Study Type Prospective. Population Twenty ME/CFS 23 healthy controls were recruited. Field Strength/Sequence Three‐b value DWI (b‐values = 0,...
Objective: In this study, we investigated the ability of fluid-attenuated inversion recovery (FLAIR) data coupled with machine-leaning algorithms to differentiate normal and epileptic brains identify laterality focus side in temporal lobe epilepsy (TLE) patients visually negative MRI. Materials Methods: The MRI were acquired on a 3-T MR system (Philips Medical Systems). After pre-proceeding stage, FLAIR signal intensities extracted from specific regions interest, such as amygdala, cerebral...
Abstract Introduction Alzheimer's disease (AD) is characterized by accumulation of extracellular amyloid‐β and intracellular tau neurofibrillary tangles. The recent advent positron emission tomography (PET) has enabled in vivo assessment pathology. aim this study was to explore whether deposition influences the structural connectivity amyloid‐negative amyloid‐positive groups, further difference between groups. Methods We investigated 18 patients with amnestic mild cognitive impairment/mild...
Recent studies detected the aberrant myelination of central nervous system (CNS) in Alzheimer's disease (AD). Here, we compared change between patients with AD and controls by a novel magnetic resonance imaging modality, "q-space myelin map (MM) imaging."Twenty 18 healthy subjects underwent MM imaging. We metric 2 groups examined relationships clinical symptoms AD.AD showed significant reduction hippocampus, insula, precuneus, anterior cingulate regions. There was also negative correlation...
Tau protein accumulation in the brain is thought to be one of causes progressive supranuclear palsy (PSP). The glymphatic system was discovered a decade ago as waste drainage that promotes elimination amyloid-beta and tau protein. We here evaluated relationships between activity regional volumes PSP patients.Subjects were 24 patients with 42 healthy participants who underwent diffusion tensor imaging (DTI). computed image analysis along perivascular space (DTI‑ALPS) index proxy activity,...
The recent advent of tau-specific positron emission tomography (PET) has enabled in vivo assessment tau pathology Alzheimer's disease (AD). However, because PET scanners have limited spatial resolution, the measured signals small brain structures or atrophied areas are underestimated by partial volume effects. aim this study was to determine whether correction (PVC) improves precision measures deposits early AD. We investigated 18 patients with amyloid-positive AD and 36 amyloid-negative...
<h3>BACKGROUND AND PURPOSE:</h3> CNS lesions of tuberous sclerosis complex are diagnosed mainly by T2WI, FLAIR, and sometimes T1WI with magnetization transfer contrast. The usefulness chemical shift selective images was recently reported in focal cortical dysplasia type IIb, which has histopathologic imaging features similar to those complex. We investigated the detecting <h3>MATERIALS METHODS:</h3> retrospectively reviewed 25 consecutive patients (mean age, 11.9 [SD, 8.9] years; 14 males)...