A5005498918- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced Glycation End Products research
- Cholinesterase and Neurodegenerative Diseases
- Neurological disorders and treatments
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Medical Imaging Techniques and Applications
- Functional Brain Connectivity Studies
- Educational Robotics and Engineering
- Kruppel-like factors research
- Wnt/β-catenin signaling in development and cancer
- Autism Spectrum Disorder Research
- Ubiquitin and proteasome pathways
- Cerebrovascular and Carotid Artery Diseases
- Attention Deficit Hyperactivity Disorder
- Schizophrenia research and treatment
- Psychiatric care and mental health services
Juntendo University
2015-2023
Sendai National College of Technology
2015
Abstract Objective Amyloid positron emission tomography (PET) can reliably detect senile plaques and fluorinated ligands are approved for clinical use. However, the impact of amyloid PET imaging is still under investigation. The aim this study was to evaluate diagnostic utility in patient management using 18 F-florbetapir patients with cognitive impairment suspected Alzheimer’s disease (AD). We also aimed determine cutoffs positivity quantitative measures by investigating agreement between...
<b><i>Background/Aims:</i></b> Mutations in the presenilin 2 <i>(PSEN2)</i> gene cause familial Alzheimer's disease (AD). Common polymorphisms affect activity and increase risk of AD. Nonsynonymous <i>PSEN2</i> showed Lewy body dementia (LBD) phenotypes clinically. Therefore, we aimed to investigate whether were associated with AD or LBD. <b><i>Methods:</i></b> Seven single nucleotide (SNPs) analyzed using a case-control...
Background/Aims Interaction of receptor for advanced glycation end products (RAGE) with amyloid‐β increases amplification oxidative stress and plays pathological roles in Alzheimer's disease (AD). Oxidative leads to α‐synuclein aggregation is also a major contributing factor the pathogenesis Lewy body dementias (LBDs). Therefore, we aimed investigate whether RAGE gene polymorphisms were associated AD LBDs. Methods Four single nucleotide (SNPs)—rs1800624, rs1800625, rs184003, rs2070600—of...
Objective: The tangram puzzle is a serious math game used to promote mathematic development in children, which improves visuospatial function and creativity. A improve cognitive functions useful for patients with neurocognitive disorders. This pilot study aimed determine whether this could Materials: recruited mild Alzheimer’s disease or impairment who were followed longitudinally by the Department of Psychiatry, Juntendo University Hospital, Tokyo Koto Geriatric Medical Center (Tokyo,...
The sequence control is used in many industrial products, and it important for the students who are studying field. Therefore we developed a learning kit self-studying with English Japanese E-learning contents. Its use to Global PBL, which collaborate some kind of country students. We think so grow up skills (communication, generic skill, global skill on).
Earlier differential diagnosis of dementia remains a major challenge. Although amyloid deposition by positron emission tomography is an emerging standard for the Alzheimer's disease, it too expensive routine use in clinical settings. We conducted pilot study on potential usefulness single-photon computed and Mini-Mental State Examination to predict positivity preclinical disease.
Objective: We aimed to investigate how primary care physicians (PCPs) in Japan use antipsychotics for treating the behavioural and psychological symptoms of dementia (BPSD).
Early-onset dementia is fast-progressing compared with late-onset dementia, major clinical characteristics including prominent focal cerebral symptoms. Given its economic and psychological implications, proper diagnosis treatment at an early stage essential. In the present study, authors conducted a retrospective study to evaluate usefulness of various numerical indices (including CIScore calculated by eZIS, blood flow SPECT analysis software) in differential early-onset dementia.