A5052262712- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Tryptophan and brain disorders
- Treatment of Major Depression
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Nicotinic Acetylcholine Receptors Study
- Cerebrovascular and Carotid Artery Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Schizophrenia research and treatment
- Neural and Behavioral Psychology Studies
- Alzheimer's disease research and treatments
- Mental Health Research Topics
- Pharmacological Receptor Mechanisms and Effects
- Smoking Behavior and Cessation
- Immune Response and Inflammation
- Long-Term Effects of COVID-19
- Substance Abuse Treatment and Outcomes
- Mental Health and Psychiatry
- Frailty in Older Adults
- Advanced MRI Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Lanthanide and Transition Metal Complexes
- Eating Disorders and Behaviors
National Center of Neurology and Psychiatry
2019-2024
National Institute of Mental Health
2019-2024
Jikei University School of Medicine
2024
Kyorin University
2024
Okayama University Hospital
2024
Neurobehavioral Systems
2016-2020
University of California, Los Angeles
2014-2020
VA Greater Los Angeles Healthcare System
2014-2020
Nagoya City University
2017
University of California, Irvine
2015
Background: In clinical practice, equivocal findings are inevitable in visual interpretation of whether amyloid positron emission tomography (PET) is positive or negative. It therefore necessary to establish a more objective quantitative evaluation method for determining the indication disease-modifying drugs currently under development. Aims: We aimed determine cutoffs positivity analysis 18 F-flutemetamol PET patients with cognitive impairment and suspected Alzheimer's disease (AD). also...
Abstract Dopamine dysfunction has been associated with depression. However, results of recent neuroimaging studies on dopamine transporter (DAT), which reflect the function dopaminergic system, are inconclusive. The aim this study was to apply texture analysis, a novel method extract information about textural properties images (e.g., coarseness), single-photon emission computed tomography (SPECT) imaging in We performed SPECT using 123 I-ioflupane measure DAT binding 150 patients major...
Abstract Aim To investigate changes in the clinical characteristics of patients who abused benzodiazepine receptor agonists (BZRA) or over‐the‐counter (OTC) drugs before and after COVID‐19 based on 2018 2022 data “Nationwide Psychiatric Hospital (NPH) Survey Drug‐related Disorders.” Method A total 446 155 cases, 435 273 mainly BZRAs OTC drugs, respectively, were extracted from database two NPH Surveys. Demographic variables, education, employment, criminal record, drug use during previous...
A relapse prevention program called the Information Technology Aided Relapse Prevention Programme in Schizophrenia (ITAREPS) has been developed and is reported to be highly effective. However effectiveness was influenced by user adherence protocol of program, exact role ITAREPS have partially uncertain.The purpose this study evaluate excluding effect program.We attempted perform a randomized controlled trial devised method with visiting nurse service. Outpatients schizophrenia were (n=22) or...
Abstract Objective Amyloid positron emission tomography (PET) can reliably detect senile plaques and fluorinated ligands are approved for clinical use. However, the impact of amyloid PET imaging is still under investigation. The aim this study was to evaluate diagnostic utility in patient management using 18 F-florbetapir patients with cognitive impairment suspected Alzheimer’s disease (AD). We also aimed determine cutoffs positivity quantitative measures by investigating agreement between...
Individuals with substance-use disorders exhibit emotional problems, including deficits in emotion recognition and processing, this class of also has been linked to dopaminergic markers the brain. Because associations between these phenomena have not explored, we compared a group recently abstinent methamphetamine-dependent individuals (n=23) healthy-control (n=17) on dopamine D2-type receptor availability, measured using positron emission tomography [18F]fallypride. The anterior cingulate...
Recent developments in image analysis have enabled an individual's brain network to be evaluated and age predicted from gray matter images. Our study aimed investigate the effects of sex on single-subject networks using a large sample healthy participants. We recruited 812 individuals (59.3 ± 14.0 years, 407 females, 405 males) who underwent three-dimensional T1-weighted magnetic resonance imaging. Similarity-based were constructed, following properties calculated: normalized clustering,...
Cigarette smoking induces dopamine release in the striatum, and smoking- or nicotine-induced ventral striatal is correlated with nicotine dependence. Smokers also exhibit lower D2/3 receptor availability dorsal striatum than nonsmokers. Negative correlations of exposure dependence, therefore, might be expected but have not been tested. Twenty smokers had positron emission tomography scans [18F]fallypride to measure regions provided self-report measures recent lifetime As reported before, was...
Cognitive assessments and neuroimaging are routinely combined in clinical practice to diagnose dementia represented by Alzheimer's disease (AD). The Montreal Assessment (MoCA) is reported be more suitable than the Mini-Mental State Examination (MMSE) for screening mild cognitive impairment (MCI) AD. On other hand, attention subfield volumes of medial temporal lobe has recently been considered important differential diagnosis early detection aim this study was uncover which specific...
This case report details the therapeutic effects of tandospirone on two patients with anorexia nervosa, one restricting subtype (ANR), and another binge-eating/purging (ANBP). A 22-year-old female patient ANR a 23-year-old ANBP were treated successfully 5-HT1A partial agonist tandospirone. After treatment, not only did both gain weight, they also showed improved scores Eating Disorder Examination Questionnaire. In addition, 6-month follow-up maintenance these effects. this disorder, may be...
In Japan, the landscape of clinical practice for substance use disorder is changing significantly, primarily due to an increase in patients using over-the-counter drugs. A major concern rising number misusing dextromethorphan (DXM). These with DXM disorders often have severe trauma-related and mood symptoms, therefore try cope those symptoms by self-medicating DXM. this article, we propose that ketamine, which has similar psychopharmacological effects DXM, may be a useful alternative...
Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for patients who misuse alcohol, especially in the context of comorbid depressive symptoms. Deficits impulse control and decision-making linked to routine alcohol consumption dependence. The goal this study was determine effects a single dose citalopram on measures impulsivity, decision-making, and/or brain dopamine receptor availability alcohol-dependent individuals. A double-blind, placebo-controlled, within-subject,...