A5013293422- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Neural dynamics and brain function
- Neurobiology of Language and Bilingualism
- EEG and Brain-Computer Interfaces
- Motor Control and Adaptation
- Biomedical Text Mining and Ontologies
- Memory and Neural Mechanisms
- Bioinformatics and Genomic Networks
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Psychological and Educational Research Studies
- Obsessive-Compulsive Spectrum Disorders
- Mental Health and Psychiatry
- Child Therapy and Development
- Cognitive Abilities and Testing
- Health, Environment, Cognitive Aging
- Adolescent and Pediatric Healthcare
- Psychology of Development and Education
- Memory Processes and Influences
- Computational Drug Discovery Methods
University of Oregon
2014-2025
University of California, Los Angeles
2005-2020
Neurobehavioral Systems
2010-2016
Brain Mapping Foundation
2002-2008
Princeton University
1999-2001
Washington University in St. Louis
2001
University of Pittsburgh
2001
University of Michigan–Ann Arbor
2001
Carnegie Mellon University
1998
Maimonides Medical Center
1973
Background: Previously we proposed that dorsolateral prefrontal cortex (PFC) supports a specific working memory (WM) subcomponent: the ability to represent and maintain context information necessary guide appropriate task behavior.By context, mean prior taskrelevant represented in such form it selection of behavioral response.Furthermore, hypothesized WM deficits schizophrenia reflect impaired processing due disturbance PFC.We use functional magnetic resonance imaging examine PFC activation...
Acquisition of a new skill is generally associated with decrease in the need for effortful control over performance, leading to development automaticity. Automaticity by definition has been achieved when performance primary task minimally affected other ongoing tasks. The neural basis automaticity was examined testing subjects serial reaction time (SRT) under both single-task and dual-task conditions. diminishing cost used as an index Subjects performed SRT during two functional magnetic...
Abstract This article describes the rationale, aims, and methodology of Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). is largest international collaboration to date that will develop algorithms predict trajectories outcomes individuals at clinical high risk (CHR) for psychosis advance development use novel pharmacological interventions CHR individuals. We present a description participating research networks data processing analysis coordination center, their processes...
Clinical ascertainment and clinical outcome are key features of any large multisite study. In the ProNET PRESCIENT research networks, Accelerating Medicines Partnership® Schizophrenia (AMP®SCZ) Ascertainment Outcome Measures Team aimed to establish a harmonized assessment protocol across these two networks define criteria primary secondary endpoints. addition developing protocol, goals this aspect AMP SCZ project were: (1) implement monitor training, participants, assessments; (2) provide...
Cognitive impairment occurs at higher rates in individuals clinical high risk (CHR) for psychosis relative to healthy peers, and it contributes unique variance multivariate prediction models of transition psychosis. Such is considered a core biomarker schizophrenia. Thus, cognition key domain measured the Accelerating Medicines Partnership® program Schizophrenia (AMP SCZ initiative). The aim this paper describe rationale, processes, considerations, final harmonization cognitive battery used...
Abstract Neuroimaging with MRI has been a frequent component of studies individuals at clinical high risk (CHR) for developing psychosis, goals understanding potential brain regions and systems impacted in the CHR state identifying prognostic or predictive biomarkers that can enhance our ability to forecast outcomes. To date, most involving are likely not sufficiently powered generate robust generalizable neuroimaging results. Here, we describe prospective, advanced, modern protocol was...
Studies of a range higher cognitive functions consistently activate region anterior cingulate cortex (ACC), typically posterior to the genu and superior corpus collosum. In particular, this ACC appears be active in task situations where there is need override prepotent response tendency, when responding underdetermined, errors are made. We have hypothesized that function monitor for presence "crosstalk" or competition between incompatible responses. prior work, we provided initial support...
This study sought to investigate neural activity in the amygdala during episodes of mania.Nine manic subjects and nine healthy comparison underwent functional magnetic resonance imaging (fMRI) while performing a neuropsychological paradigm known activate amygdala. Subjects viewed faces displaying affect (experimental task) geometric forms (control matched them one two simultaneously presented similar images.Manic had significantly increased activation left reduced bilateral lateral...
While undergoing fMRI, six patients with DSM IV diagnosis of panic disorder and normal controls performed directed imagery neutral, moderate high anxiety situations based on an individually determined behavioral hierarchy. Brain activity was compared during vs neutral blocks for each group subjects using SPM99b. Panic showed increased in inferior frontal cortex, hippocampus throughout the cingulate both anterior posterior, extending into orbitofrontal cortex encompassing hemispheres. These...
Objective: To investigate neural activity in prefrontal cortex and amygdala during bipolar depression. Methods: Eleven I depressed 17 normal subjects underwent functional magnetic resonance imaging (fMRI) while performing a task known to activate amygdala. Whole brain activation patterns were determined using statistical parametric mapping (SPM) when matched faces displaying neutral or negative affect (match condition) geometric form (control condition). Contrasts for each group the match...
It has been suggested that patients with schizophrenia have corticostriatal circuit dysfunction (Carlsson & Carlsson, 1990). Skill learning is thought to rely on circuitry and different types of skill may be related separable loops (Grafton, Hazeltine, Ivry, 1995; Poldrack, Prabhakaran, Seger, Gabrieli, 1999). The authors examined motor (Serial Reaction Time task, SRT) cognitive (Probabilistic Classification PCT) in normal controls. Development automaticity was examined, using a dual task...
Introduction Understanding the relationship between brain and complex latent behavioral constructs like cognitive control will require an inordinate amount of data. Internet-based methods can rapidly efficiently refine measures in very large samples that are needed for genetics research. Cognitive is a multifactorial construct considered to be endophenotype numerous neuropsychiatric disorders, including attention deficit/hyperactivity disorder (ADHD). While previous studies have demonstrated...