A5050613769- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Mental Health Treatment and Access
- Psychosomatic Disorders and Their Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Bipolar Disorder and Treatment
- Neuroscience and Music Perception
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Neural dynamics and brain function
- Personality Disorders and Psychopathology
- Neurobiology of Language and Bilingualism
- Olfactory and Sensory Function Studies
- Autism Spectrum Disorder Research
- Mental Health via Writing
- Family Caregiving in Mental Illness
- Biochemical Analysis and Sensing Techniques
- Digital Mental Health Interventions
- Machine Learning in Healthcare
- Advanced Chemical Sensor Technologies
Icahn School of Medicine at Mount Sinai
2004-2025
James J. Peters VA Medical Center
2019-2024
Mental Illness Research, Education and Clinical Centers
2019-2024
United States Department of Veterans Affairs
2021-2024
The King's College
2024
The University of Melbourne
2011-2023
Orygen
2023
Columbia University
2011-2021
City University of New York
2013-2021
The Graduate Center, CUNY
2013-2021
Psychiatry lacks the objective clinical tests routinely used in other specializations. Novel computerized methods to characterize complex behaviors such as speech could be identify and predict psychiatric illness individuals.In this proof-of-principle study, our aim was test automated analyses combined with Machine Learning later psychosis onset youths at high-risk (CHR) for psychosis.Thirty-four CHR (11 females) had baseline interviews were assessed quarterly up 2.5 years; five transitioned...
<h3>Context</h3> Because schizophrenia and related disorders have a chronic time course subtle histopathology, it is difficult to identify which brain regions are differentially targeted. <h3>Objective</h3> To sites targeted by schizophrenia, we applied high-resolution variant of functional magnetic resonance imaging clinically characterized patients matched healthy controls cohort prodromal subjects who were prospectively followed up. Additionally, explore the potential confound medication...
Language and speech are the primary source of data for psychiatrists to diagnose treat mental disorders. In psychosis, very structure language can be disturbed, including semantic coherence (e.g., derailment tangentiality) syntactic complexity concreteness). Subtle disturbances in evident schizophrenia even prior first psychosis onset, during prodromal stages. Using computer-based natural processing analyses, we previously showed that, among English-speaking clinical ultra) high-risk youths,...
<h3>Objective</h3> The association of primary oncologist specialty, medical oncology versus gynecologic oncology, on intensity care at the end life in elderly patients with cancer is unclear. <h3>Methods</h3> This retrospective cohort study used Surveillance, Epidemiology and End Results-Medicare (SEER-M) data. Subjects were fee-for-service Medicare enrollees aged 65 years older who died a between January 2006 December 2015. outcome was composite score for high-intensity received last month...
Abstract This article describes the rationale, aims, and methodology of Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). is largest international collaboration to date that will develop algorithms predict trajectories outcomes individuals at clinical high risk (CHR) for psychosis advance development use novel pharmacological interventions CHR individuals. We present a description participating research networks data processing analysis coordination center, their processes...
Abstract Schizophrenia has been linked with intrauterine exposure to maternal stress due bereavement, famine and major disasters. Recent evidence suggests that human vulnerability may be greatest in the first trimester of gestation rodent experiments suggest sex specificity. We aimed describe consequence an acute stress, through a follow-up offspring whose mothers were pregnant during Arab-Israeli war 1967. A priori, we focused on gestational month offspring's sex. Method In pilot study...
To examine 3-year rates of conversion to dementia, and risk factors for such conversion, in a population-based sample with diverse types cognitive impairment.All elderly (aged 65 or older) residents Cache County, UT, were invited undergo two waves dementia screening assessment. Three-year follow-up data available 120 participants who had some form mild impairment at baseline. Of these, 51 been classified baseline prodromal Alzheimer disease (proAD), 69 other syndromes (CS).Three-year 46%...
Background Social dysfunction is a hallmark symptom of schizophrenia which commonly precedes the onset psychosis. It unclear if social symptoms in clinical high-risk patients reflect depressive or are manifestation negative symptoms. Method We compared function scores on Adjustment Scale-Self Report between 56 young people (aged 13–27 years) at high risk for psychosis and 22 healthy controls. The cases were also assessed ‘prodromal’ (subthreshold positive, negative, disorganized general...
Background. Schizophrenia is characterized by profound and disabling deficits in the ability to recognize emotion facial expression tone of voice. Although these are well documented established schizophrenia using recently validated tasks, their predictive utility at-risk populations has not been formally evaluated. Method. The Penn Emotion Recognition Discrimination developed measures auditory recognition, were administered 49 clinical high-risk subjects prospectively followed for 2 years...
Objective The use of psychotropic medications in Alzheimer's disease (AD) has been associated with both deleterious and potentially beneficial outcomes. We examined the longitudinal association medication cognitive, functional, neuropsychiatric symptom (NPS) trajectories among community‐ascertained incident AD cases from Cache County Dementia Progression Study. Methods A total 230 participants were followed for a mean 3.7 years. Persistency index (PI) was calculated all antidepressants,...
Objective The ability to read passages of information fluently and with comprehension is a basic component socioeconomic success. Reading depends on the integrity underlying visual auditory (phonological) systems. This study investigated reading in schizophrenia relative function. Method participants were 45 patients, 19 clinical high-risk 65 comparison subjects. was assessed using tests sensitive or phonological dysfunction. Sensory, neuropsychological, functional outcome measures also...