A5086875861- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced NMR Techniques and Applications
- NMR spectroscopy and applications
- Atomic and Subatomic Physics Research
- Transcranial Magnetic Stimulation Studies
- Metabolomics and Mass Spectrometry Studies
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Medical Imaging Techniques and Applications
- Acute Ischemic Stroke Management
- Neonatal and fetal brain pathology
- MRI in cancer diagnosis
- Advanced Glycation End Products research
- Metabolism and Genetic Disorders
- Neuroscience and Neuropharmacology Research
- Lanthanide and Transition Metal Complexes
- Diet, Metabolism, and Disease
- Spectroscopy and Chemometric Analyses
- Cardiac Imaging and Diagnostics
- Marriage and Sexual Relationships
- Hemoglobinopathies and Related Disorders
Medical University of South Carolina
2015-2024
Columbia University
2006-2023
University of Charleston
2023
Laboratoire d’Imagerie Biomédicale
2021
UNICEF East Asia and Pacific Regional Office
2019
Continental (Germany)
2019
Institute for Biomedicine
2019
Advanced Imaging Research (United States)
2015-2016
The Neurological Institute
2001-2013
Columbia University Irving Medical Center
2010-2012
With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate neurogenesis has become important goal. Here we rely on coupling between and angiogenesis test whether MRI measurements cerebral blood volume (CBV) provide imaging neurogenesis. First, used approach to generate CBV maps time hippocampal formation exercising mice. Among all subregions, exercise was found have a primary effect dentate gyrus CBV, only subregion that supports Moreover,...
A method for obtaining the three-dimensional distribution of chemical shifts in a spatially inhomogeneous sample using Fourier transform NMR is presented. The uses sequence pulsed field gradients to measure desired on rectangular grid (k,t) space. Simple inversion then recovers original distribution. An estimated signal/noise ratio 20 10 min obtained an "image" mM phosphorylated metabolite human head at kG with 2-cm resolution.
<h3>Context</h3> Because schizophrenia and related disorders have a chronic time course subtle histopathology, it is difficult to identify which brain regions are differentially targeted. <h3>Objective</h3> To sites targeted by schizophrenia, we applied high-resolution variant of functional magnetic resonance imaging clinically characterized patients matched healthy controls cohort prodromal subjects who were prospectively followed up. Additionally, explore the potential confound medication...
This review presents the principles and limitations of phosphorus nuclear magnetic resonance (31P-NMR) spectroscopy as applied to study striated muscle metabolism. Application techniques discussed include noninvasive measurement high-energy phosphate, intracellular pH, free Mg2+, metabolite compartmentation. In perfused cat biceps (fast-twitch) muscle, but not in soleus (slow-twitch), NMR spectra indicate a substantially lower (1 mM) inorganic phosphate level than when measured chemically (6...
BACKGROUND New-onset Alzheimer disease (AD) is often attributed to degenerative changes in the hippocampus. However, contribution of regionally distributed small vessel cerebrovascular disease, visualized as white matter hyperintensities (WMHs) on magnetic resonance imaging, remains unclear. OBJECTIVE To determine whether regional WMHs and hippocampal volume predict incident AD an epidemiological study. DESIGN A longitudinal community-based study older adults from northern Manhattan, New...
✓ The authors represent a cooperative group of 15 institutions that examined the feasibility using metabolic features observed in vivo with 1 H-magnetic resonance (MR) spectroscopy to characterize brain tumors glial type. provided blinded, centralized MR data processing along independent central review voxel placement, composition and contamination by brain, histopathological typing current World Health Organization criteria, clinical data. Proton H-MR was performed spin-echo technique...
Phosphorus nuclear magnetic resonance (NMR) spectra were obtained at 109.3 MHz from isolated, arterially perfused cat biceps brachi (greater than 75% fast-twitch, glycolytic fibers) and soleus 92% slow-twitch, oxidative) muscles 30 degrees C. The stable with respect to O2 consumption, twitch characteristics, ATP phosphocreatine (PC) levels for up 10 h. NMR showed a higher PC/Pi ratio in the (11) (1.7). Relatively Pi observed extracts of clamp-frozen intact muscles. This difference could be...
Phosphorus nuclear magnetic resonance spectra and steady-state O2 consumption rates were obtained from ex vivo arterially perfused cat biceps brachii (fast twitch) soleus (slow muscles during after periods of isometric twitch stimulation at 30 degrees C. In the muscles, increased phosphocreatine (PCr) concentration decreased progressively with stimulation. PCr recovery these followed first-order kinetics a half time 10 min. The results in could be explained by feedback control cellular...
<h3>Background</h3> Aging is accompanied by a decrease in brain volume and an increase cerebrovascular disease. <h3>Objective</h3> To examine the effects of age, sex, race/ethnicity, vascular disease history on measures morphology, including relative volume, ventricular hippocampus entorhinal cortex volumes, white matter hyperintensity (WMH) burden, large community-based cohort racially/ethnically diverse older adults without dementia. <h3>Design</h3> The associations self-reported with...
Abstract Partial volume effects (PVE) are a consequence of limited spatial resolution in brain imaging. In arterial spin labeling (ASL) MRI, the problem is exacerbated by nonlinear dependency ASL signal on magnetization contributions from each tissue within an imaged voxel. We have developed algorithm that corrects for PVE The based model represents voxel intensity as weighted sum pure contribution, where weighting coefficients tissue's fractional Using this algorithm, we were able to...
Fructose 3-phosphate, a novel monosaccharide phosphate, has been identified in the lens of diabetic rats. This compound, which is not present normal lenses, protein glycosylating agent and enzyme inactivator. In addition, because its structural features, this metabolite relatively labile undergoes hydrolysis to yield inorganic phosphate potent agent, 3-deoxyglucosone. The increase concentration fructose 3-phosphate rats suggests that it product, 3-deoxyglucosone, may be responsible part for...
<h3>Background</h3> The importance of subclinical cerebrovascular disease in the elderly is increasingly recognized, but its determinants have not been fully explicated. Elevated blood pressure (BP) and fluctuation BP may lead to through ischemic changes compromised cerebral autoregulation. <h3>Objective</h3> To determine association long-term with disease. <h3>Design</h3> A community-based epidemiological study older adults from northern Manhattan. <h3>Setting</h3> Washington Heights–Inwood...
Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be both, studies of relationship between tHcy quantitative measures white hyperintensity volume (WMHV) are lacking, especially in minority populations.A community-based sample 259 subjects with baseline levels underwent pixel-based measurement WMHV. We examined WMHV adjusting age, sociodemographics, vascular factors, B12 deficiency.Higher...
We examined white matter hyperintensity volume (WMHV) and subclinical infarction (no history of clinical stroke; SI) in relation to performance on tests sequencing, cognitive flexibility, sensorimotor ability.The Northern Manhattan Study includes a stroke-free community-based sample Hispanic, Black, White participants. A subsample (n=656) has undergone measurement WMHV, SI, neuropsychological testing. Linear regression was used examine WMHV SI sequencing as measured by Color Trails 1,...
1. The activity of creatine kinase in intact anaerobic frog muscle at 4 degrees C rest and during contraction was investigated by using saturation-transfer 31P n.m.r. 2. At rest, the measured forward (phosphocreatine to ATP) reaction flux 1.7 × 10(-3) M . s-1 backward 1.2 s-1. large magnitude both fluxes shows that is active resting muscle, so observed constancy [phosphocreatine] demonstrates enzyme its substrates are equilibrium. 3. apparent discrepancy between must arise largely from an...
Abstract Objective To rely on the anatomical organization of hippocampal formation in understanding whether and how late‐life diseases such as diabetes stroke contribute to age‐related cognitive decline. Methods Magnetic resonance imaging (MRI) was used document brain infarcts generate high‐resolution functional maps 240 community‐based nondemented elders (mean age, 79.7 years) who received a comprehensive medical evaluation. Sixty participants had type 2 mellitus, whereas 74 MRI‐documented...
Continuous arterial spin labeling (CASL) magnetic resonance imaging (MRI) was combined with multivariate analysis for detection of an Alzheimer's disease (AD)-related cerebral blood flow (CBF) covariance pattern. Whole-brain resting CBF maps were obtained using echo, echo planar (SE-EPI) CASL in patients mild AD ( n=12, age=70.7±8.7 years, 7 males, modified Mini-Mental State Examination (mMMS)=38.7/57±11.1) and age-matched healthy controls (HC) n=20; age=72.1±6.5 8 males). A pattern which...
Abstract Patient motion during an MRI exam can result in major degradation of image quality, and is increasing concern due to the aging population its associated diseases. This work presents a general strategy for real‐time, intraimage compensation rigid‐body that compatible with multiple imaging sequences. Image quality improvements are established structural brain acquired volunteer motion. A headband integrated three active markers secured forehead. Prospective correction achieved by...
Risk factors for subclinical brain infarcts (SBI) have not been well studied, especially in Hispanic and black populations who may be at higher risk vascular disease. We examined the prevalence determinants of SBI a multiethnic community cohort.The Northern Manhattan Study (NOMAS) includes 892 stroke-free participants underwent MRI. Baseline demographic factor data were collected. The presence was determined from size, location, imaging characteristics lesion based on fluid attenuated...
Cortical and subcortical networks have been identified that are commonly associated with attention task engagement, along theories regarding their functional interaction. However, a link between these systems has not yet demonstrated in healthy humans, primarily because of data acquisition analysis limitations. We recorded simultaneous EEG–fMRI while subjects performed auditory visual oddball tasks used to investigate the BOLD correlates single-trial EEG variability at latencies spanning...