A5076573845- Inflammasome and immune disorders
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
- Pharmaceutical studies and practices
- Neurological disorders and treatments
- Influenza Virus Research Studies
- Advanced Neuroimaging Techniques and Applications
- Respiratory viral infections research
- Health, Environment, Cognitive Aging
- Phytochemistry Medicinal Plant Applications
- Adenosine and Purinergic Signaling
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- S100 Proteins and Annexins
- MXene and MAX Phase Materials
- Data-Driven Disease Surveillance
- Pregnancy and preeclampsia studies
- Graphene research and applications
- Biochemical effects in animals
- Bone Metabolism and Diseases
- Obstructive Sleep Apnea Research
- Autism Spectrum Disorder Research
University of Coimbra
2019-2024
Centro Hospitalar de Lisboa Central
2022-2023
King's College London
2023
The University of Adelaide
2023
Bial (Portugal)
2019-2022
Centro de Neurociências e Biologia Celular
2022
Clinical Academic Center of Braga
2022
University of Algarve
2018-2020
Icahn School of Medicine at Mount Sinai
2017
Allen Institute for Brain Science
2017
With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate neurogenesis has become important goal. Here we rely on coupling between and angiogenesis test whether MRI measurements cerebral blood volume (CBV) provide imaging neurogenesis. First, used approach to generate CBV maps time hippocampal formation exercising mice. Among all subregions, exercise was found have a primary effect dentate gyrus CBV, only subregion that supports Moreover,...
Background. Severe acute respiratory infections (SARI) surveillance is recommended to assess the severity of disease. In 2021, National Institute Health Doutor Ricardo Jorge, in collaboration with two general hospitals, implemented a SARI sentinel system based on electronic health registries. We describe its application 2021/2022 season and compare evolution cases COVID-19 influenza activity regions Portugal. Methods. The main outcome interest was weekly incidence patients hospitalized due...
Propolis is a bee product used since ancient times due to its diverse biological applications. We aimed investigate the antioxidant and anti-inflammatory action of Brazilian propolis in THP-1 cells stimulated with 1‐fluoro‐2,4‐dinitrobenzene (DNFB) or lipopolysaccharide (LPS). Cell viability was assessed by resazurin assay, activity evaluated DPPH superoxide dismutase (SOD) 1 2 colorimetric assay. CD86 expression determined flow cytometry. IL-1β HMOX-1 were analysed Western blot. did not...
Significance Sleep-disordered breathing (SDB), characterized by intermittent hypoxia and sleep fragmentation during sleep, is common in the elderly can contribute to cognitive decline, with significant impairment of executive function, including mental flexibility, problem solving, working memory, which are under dorsolateral prefrontal cortex (DLPFC) control. The results present study suggest a potential mechanism SDB hypoxia-driven deficit DLPFC γ-aminobutyric acid (GABA), major inhibitory...
Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) is a crucial component of the cellular machinery responsible for homeostasis. The selective inhibition SERCA by thapsigargin (TG) leads to perturbations in signaling, which can trigger endoplasmic (ER) stress. unfolded protein response (UPR) pathway activated ER stress and induces an adaptive preserve cell survival or committee cells programmed death, depending on duration and/or level. Early stages stimulate mitochondrial metabolism but under...
Nitric oxide (NO) is well established as a regulator of neurogenesis. NO increases the proliferation neural stem cells (NSC), and essential for hippocampal injury-induced neurogenesis following an excitotoxic lesion. One mechanisms underlying non-classical cell signaling protein S-nitrosylation. This post-translational modification consists in formation nitrosothiol group (R-SNO) cysteine residues, which can promote other oxidative modifications those residues. S-nitrosylation regulate many...
Levodopa remains the cornerstone treatment for Parkinson's disease (PD) but its use is associated with development of 'wearing-off' fluctuations and other motor non-motor complications over time. Adding a catechol-O-methyltransferase (COMT) inhibitor to levodopa/dopa decarboxylase (DDC) therapy reduces in profile plasma levodopa levels following oral dosing, can therefore be beneficial management complications. The objective EPSILON study investigate efficacy opicapone (OPC;...
Abstract Brain function is the dynamic output of coordinated excitatory and inhibitory (E-I) activity. E-I alterations, arising from differences in glutamate GABA pathways, are implicated development heterogeneity multiple neurodevelopmental conditions, such as autism; consequently targets for pharmacological support options. Yet, measures neurotransmitter levels or receptors living human brain (such Magnetic Resonance Spectroscopy Positron Emission Tomography) expensive and/or invasive do...
In order to obtain additional insights into the zinc (Zn) and strontium (Sr) effects on bone formation, zebrafish (Danio rerio) was used as a recognized model for vertebrate skeletogenesis. The treatments began 5 days post-fertilization, using triplicates each test condition, with 100 larvae per replicate trials 80 trials. Tanks were maintained at 28 ºC temperature photoperiod control (recirculation system ZebTECH, Tecniplast). Diets undergoing vertebrae formation mineralization (from 30...
An anterior disconnection syndrome was first described over 100 years ago by Liepmann and Maas[1][1] brought back to clinical awareness 50 Geschwind Kaplan.[2][2] Damage the corpus callosum has been confirmed postmortem analysis but precise anatomic along with its
Background Severe Acute Respiratory Infections (SARI) surveillance is recommended to assess severity of respiratory infections disease. In 2021, the National Institute Health Doutor Ricardo Jorge, in collaboration with two central hospitals, implemented a SARI sentinel system based on electronic health registries. We describe its application 2021/2022 season and compare evolution cases COVID-19 influenza activity regions Portugal. Methods identified ICD-10 codes for influenza-like illness,...
Evaluate efficacy and safety of Eslicarbazepine acetate (ESL) monotherapy during long-term treatment.
Abstract This paper demonstrates a new concept of using two-dimensional (2D) layered materials and their heterostructures for enhanced X-ray radiation shielding. phenomenon is revealed by characterization the shielding performances several 2D with high atomic numbers (Z) including MoS 2 , antimonene (Sb), MXene prepared as multi-layered heterostructured films assembly few-layer (FL) sheets. Results showed considerable enhancement (40-50 %) at 30kVp individual compared bulk structures these...
Abstract Objective There is conflicting research on risk indicators relating to the diagnosis of early-onset Alzheimer’s disease (EOAD). We assessed an individual with numerous factors that are associated EOAD including presence two APOE e4 alleles, family history EOAD, and positive biomarkers (i.e., Amyloid PET Scan; CSF). Longitudinal neuropsychological data reflect minimal cognitive decline through age 73, suggesting substantial mediating effects reserve neuroprotective measures: aerobic...
Bipolar disorder (BD) is a mental illness characterized by mood swings between depression and mania resulting in cognitive functional impairments that require lifetime treatment.Few treatments are currently available with limited efficacy delayed/misdiagnosis frequent due to biomarkers absence.Alterations of cellular resilience, endoplasmic reticulum (ER) stress response, mitochondrial function innate immunity have been implicated BD pathophysiology.Aforementioned events closely associated...