A5067274454- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Natural Antidiabetic Agents Studies
- melanin and skin pigmentation
- Phase Equilibria and Thermodynamics
- Biochemical Analysis and Sensing Techniques
- Phytochemicals and Antioxidant Activities
- Allelopathy and phytotoxic interactions
- Non-Invasive Vital Sign Monitoring
- Biochemical and biochemical processes
- Alzheimer's disease research and treatments
- Bee Products Chemical Analysis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Phytochemistry Medicinal Plant Applications
- Ginkgo biloba and Cashew Applications
- Skin Protection and Aging
- Cardiovascular Health and Disease Prevention
- Antioxidant Activity and Oxidative Stress
- Seed and Plant Biochemistry
- Diet and metabolism studies
- Advanced Fiber Optic Sensors
- Polysaccharides and Plant Cell Walls
- Adipose Tissue and Metabolism
- Advancements in Transdermal Drug Delivery
- Hemodynamic Monitoring and Therapy
Rede de Química e Tecnologia
2012-2024
University of Coimbra
2013-2024
Instituto Superior Técnico
2012
Eucalyptus globulus is planted extensively for pulp, paper and wood production. Although bioactive compounds obtained from its biomass are used as cosmetics ingredients, the skin effects were not yet fully explored. In order to fill this gap, work aimed study protective effect against damage provided by essential oil (EO) hydrodistillation of leaves, an extract residual water (HRW). The major compound identified in EO was 1,8-Cineole, phenolic acids HRW included gallic acid main constituent....
Propolis is a bee product used since ancient times due to its diverse biological applications. We aimed investigate the antioxidant and anti-inflammatory action of Brazilian propolis in THP-1 cells stimulated with 1‐fluoro‐2,4‐dinitrobenzene (DNFB) or lipopolysaccharide (LPS). Cell viability was assessed by resazurin assay, activity evaluated DPPH superoxide dismutase (SOD) 1 2 colorimetric assay. CD86 expression determined flow cytometry. IL-1β HMOX-1 were analysed Western blot. did not...
Supercritical fluid extraction of all-E-lycopene from tomato industrial wastes (mixture skins and seeds) was carried out in a semi-continuous flow apparatus using ethane as supercritical solvent. The effect pressure, temperature, feed particle size, solvent superficial velocity matrix initial composition evaluated. Moreover, the yield compared with that obtained other solvents (supercritical CO2 near critical mixture propane). recovery increased decreased increase size stages not practically...
The paramount importance of a healthy diet in the prevention type 2 diabetes is now well recognized. Blueberries (BBs) have been described as attractive functional fruits for this purpose. This study aimed to elucidate cellular and molecular mechanisms pertaining protective impact blueberry juice (BJ) on prediabetes. Using hypercaloric diet-induced prediabetic rat model, we evaluated effects BJ glucose, insulin, lipid profiles; gut microbiota composition; intestinal barrier integrity;...
Overexpression of melanin contributes to darkening plant and fruit tissues skin hyperpigmentation, leading melasma or age spots. Although biosynthesis is complex involves several steps, a single enzyme known as tyrosinase key regulating this process. The melanogenesis pathway initiated by oxidation the starting material l-tyrosine (or l-DOPA) dopaquinone tyrosinase; resulting quinone then serves substrate for subsequent steps that eventually lead production melanin. Medicinal plants are...
This work expands the phytochemical composition knowledge of Acanthus mollis and evaluates antioxidant anti-inflammatory activities which could be related with its traditional uses. Extracts from leaves, obtained by sequential extraction, were screened using TLC HPLC-PDA. The ethanol extract was most active on DPPH assay (IC50 = 20.50 μg/mL) inhibited nitric oxide (NO) production in RAW 264.7 macrophages 48.31 μg/mL). Significant amounts cyclic hydroxamic phenolic acids derivatives detected....
Topical formulations of Acanthus mollis L. leaf and the optimization release their active compounds topical bioavailability were investigated for first time. In vitro, from three formulations—an oil-in-water cream two hydrogels (Carbopol 940 Pluronic F-127)—was determined using Franz diffusion cells. Detection quantification was performed via high-performance liquid chromatography with a photodiode array (HPLC-PDA). DIBOA, bioactive compound this medicinal plant, exhibited kinetics Weibull...