A5076297102- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Bee Products Chemical Analysis
- SARS-CoV-2 detection and testing
- Contact Dermatitis and Allergies
- CAR-T cell therapy research
- Inflammasome and immune disorders
- Biosensors and Analytical Detection
- Cancer Immunotherapy and Biomarkers
- Adenosine and Purinergic Signaling
- Advancements in Transdermal Drug Delivery
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Advanced biosensing and bioanalysis techniques
- Immunotoxicology and immune responses
- COVID-19 Clinical Research Studies
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 Impact on Reproduction
- Drug-Induced Adverse Reactions
- Wound Healing and Treatments
- Medicinal Plants and Neuroprotection
- Reproductive System and Pregnancy
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
University of Coimbra
2020-2025
The COVID-19 pandemic has driven immunity acquisition through infection or vaccination, leading to SARS-CoV-2 antibodies. This study introduces a colorimetric biosensor for screening using Virus-Like Particles (VLPs) with spike protein motifs on cellulose carrier. was chemically modified DSS secure the VLPs, verified via FTIR. Detection utilized Bradford reagent, RGB color analysis ImageJ and smartphone images. test strips demonstrated high sensitivity (R > 0.998) across 10-40 µg/mL range in...
The immunomodulatory properties of β-glucans have sparked interest among various medical fields. As vaccine adjuvants, glucan particles offer additional advantages as antigen delivery systems. This study reported the with different size and chemical composition. effect microparticles (GPs) nanoparticles (Glu 130 355 NPs) was evaluated on human immune cells. While GPs Glu NPs demonstrated substantial interaction Dectin-1 receptor monocytes, exhibited reduced activation this receptor....
Propolis is a bee product used since ancient times due to its diverse biological applications. We aimed investigate the antioxidant and anti-inflammatory action of Brazilian propolis in THP-1 cells stimulated with 1‐fluoro‐2,4‐dinitrobenzene (DNFB) or lipopolysaccharide (LPS). Cell viability was assessed by resazurin assay, activity evaluated DPPH superoxide dismutase (SOD) 1 2 colorimetric assay. CD86 expression determined flow cytometry. IL-1β HMOX-1 were analysed Western blot. did not...
Dendritic cells (DCs) are the most specialized and proficient antigen-presenting cells. They bridge innate adaptive immunity display a powerful capacity to prime antigen-specific T The interaction of DCs with receptor-binding domain spike (S) protein from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is pivotal step induce effective against S protein-based vaccination protocols, as well SARS-CoV-2 virus. Herein, we describe cellular molecular events triggered by virus-like...
The pursuit of cosmetic ingredients with proven efficacy and safety that meet consumer needs drives the advancement new products. Ascorbic acid (AA) is utilized in products, predominantly for its potent antioxidant properties. Nonetheless, instability compromises efficacy. In this work, ascorbyl 2-
Resveratrol (RSV), a naturally occurring metabolite, is widely used in skincare products, but its hydrophobicity impairs own incorporation into cosmetic formulations. RSV-GS synthetic hydrophilic sulfated glycosylated derivative inspired by marine natural products that present lower cytotoxicity than RSV while exhibiting similar levels of bioactivity. Herein, we predict the skin sensitization potential this new compound using an vitro approach based on OECD 442E guideline. Furthermore,...
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Event Abstract Back to Role of adenosine on the resistance an anti-tumor agent in glioblastoma cell lines Vanda S. Nogueira1, 2, Ana M. Sebastião1, 3*, José F. Cascalheira2* and Claudia A. Valente1, 3* 1 Unidade de Farmacologia Clínica, Instituto Medicina Molecular (IMM), Universidade Lisboa, Portugal 2 Faculty Health Sciences, University Beira Interior, 3 Institute Medicine, Lisbon, Glioblastoma is a primary brain tumor glial cells with high incidence adults one most abundant cancer...
Event Abstract Back to Astrocytic signaling upon Aβ-mediated excitotoxicity Joana I. Gomes1, 2, João F. Hugo V. Miranda3, Ana M. Sebastião1, Maria José Diógenes1, 2 and Sandra H. Vaz1, 2* 1 Institute of Molecular Medicine, Faculty University Lisbon, Portugal Pharmacology Neurosciences, 3 Center for Chronic Disease Studies (CEDOC), Alzheimer’s (AD) is an aged-dependent neurodegenerative disease characterized by progressive deterioration cognitive function. Amyloid beta (Aβ) accumulation...
Event Abstract Back to NLRP3 Inflammasome assembly in microglia-induced reactive astrocytes Antónia Fortunato1, 2, Catarina C. Almeida1, Ana M. Sebastião1, 2* and Claudia A. Valente1, 1 Institute of Pharmacology Neurosciences, Faculty Medicine, University Lisbon, Portugal 2 Molecular Microglia work together as the immune effectors Central Nervous System (CNS). Upon a prolonged insult or injury, these cells acquire reactive, pro-inflammatory phenotype, resulting neuronal damage [1]. At core...
Event Abstract Back to The inhibitory effect of adenosine on human astrocyte proliferation is absent in glioblastoma cell lines. Helena Marcelino1, 2, Cecilia R. Santos2, Vanda S. Nogueira2, 3, 4, João F. Fonseca-Gomes3, Joana Tomás2, Maria José Diógenes3, Ana M. Sebastião3, 4 and Cascalheira1, 2* 1 Department Chemistry, Faculty Sciences, University Beira Interior, Portugal 2 Center for Research Health 3 Institute Pharmacology Neurosciences, Medicine, Lisbon, Molecular Medicine Lobo Antunes,...