A5022348296- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Electrochemical sensors and biosensors
- MicroRNA in disease regulation
- Electrochemical Analysis and Applications
- SARS-CoV-2 detection and testing
- Analytical Chemistry and Sensors
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Extracellular vesicles in disease
- Analytical chemistry methods development
- Advanced Nanomaterials in Catalysis
- Alzheimer's disease research and treatments
- Advanced Biosensing Techniques and Applications
- SARS-CoV-2 and COVID-19 Research
- Neurological disorders and treatments
- Graphene and Nanomaterials Applications
- Microfluidic and Capillary Electrophoresis Applications
- Cell Adhesion Molecules Research
- Breast Implant and Reconstruction
- Mass Spectrometry Techniques and Applications
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Social Policy and Reform Studies
- Lung Cancer Treatments and Mutations
University of Coimbra
2020-2024
Polytechnic Institute of Porto
2016-2023
University of Minho
2018-2022
University of Lisbon
2022
Universidade Nova de Lisboa
2018-2021
Instituto Português de Oncologia Francisco Gentil
2021
IPO Porto
2021
Instituto Superior de Engenharia do Porto
2018
Centre for Health Technology and Services Research
2016-2017
This work, describes for the first time, a simple biosensing design to yield an ultrasensitive electrochemical biosensor cancer biomarker detection, miRNA-155, with linear response down attomolar range. MiRNA-155 was selected being overexpressed in breast cancer. The assembled two stages: (1) immobilization of anti-miRNA-155 that thiol modified on Au-screen printed electrode (Au-SPE), followed by (2) blocking areas non-specific binding mercaptosuccinic acid. Atomic force microscopy (AFM) and...
Expanding the single molecule detection, enabled by laser-induced graphene (LIG) technology, for portable and on-site analysis, a dual system with two-working-electrode architecture was developed ascorbic acid (AA) amoxicillin (AMOX) which are currently used in aquaculture persist as water contaminants. The biorecognition element of each target compound suitable molecularly imprinted polymer (MIP). AMOX MIP herein first time assembled electropolymerization eriochrome black T (EBT). It showed...
Extracellular vesicles (EVs) contain biomarkers that may represent a paradigm shift in timely disease diagnosis and personalized therapeutic approaches. Despite tremendous progress this field, the considerable complexity heterogeneity of EVs, combined with hurdles isolation accurate characterization, have delayed their envisioned clinical translation. At same time, emerging biosensor technologies are trying to overcome limitations provide new momentum EVs research. In review, focus is given...
Extracellular vesicles are involved in many physiological and pathological activities. They transport miRNAs to recipient cells during their role intercellular communication, making them emerging biomarkers of diseases. Interest exosomal has grown after they have shown numerous advantages as for diagnosis, prognosis, evaluation cancer treatment. This work describes the development a biosensor detection 21-5p miRNA human serum using screen-printed carbon electrodes modified with gold...
Abstract Background The aerobic glycolysis as energy source in cancer confers a selective advantage for its proliferation and survival. Previous vitro studies demonstrated that treatment with [C16Pyr][Amp], potential anti-cancer drug prostate, decreased the transcript levels of LDHA CPT2, both involved metabolic plasticity. In fact, CPT2 were reported to be overexpressed cancer, association poor prognosis resistance chemo- radiotherapy. Since can therapy biomarkers, aim this work was assess...
A presença de células endometriais é considerada um fator alerta em esfregaços ginecológicos mulheres na segunda metade do ciclo menstrual ou a partir dos 45 anos. Em pós-menopáusicas, atípicas pode revelar uma patologia uterina grave e requer avaliação mais aprofundada.Apresentamos caso mulher 77 anos, pós-menopausa, que se apresentava com perda hemática vaginal sem alterações uterinas à ecografia. O exame citológico revelou grupos atipia nuclear, dentro contexto clínico da...