A5021058548- Glioma Diagnosis and Treatment
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Nitric Oxide and Endothelin Effects
- Cancer Cells and Metastasis
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Retinal Imaging and Analysis
- Chemokine receptors and signaling
- Microtubule and mitosis dynamics
- COVID-19 Clinical Research Studies
- Autophagy in Disease and Therapy
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Youth, Drugs, and Violence
- Cancer Mechanisms and Therapy
- Pomegranate: compositions and health benefits
- Neurogenesis and neuroplasticity mechanisms
- Ocular Infections and Treatments
- interferon and immune responses
- Immunotherapy and Immune Responses
- Business and Management Studies
- Tannin, Tannase and Anticancer Activities
- Epigenetics and DNA Methylation
- Brain Metastases and Treatment
Hospitais da Universidade de Coimbra
2016-2024
Clinical Academic Center of Braga
2022
University of Coimbra
2007-2019
Centro de Neurociências e Biologia Celular
2013-2018
Association for Innovation and Biomedical Research on Light and Image
1998-2018
Escola Universitária Vasco da Gama
2007-2015
Patients with coronavirus disease-2019 may be discharged based on clinical resolution of symptoms, and evidence for viral RNA clearance from the upper respiratory tract. Understanding severe acute syndrome 2 (SARS-CoV-2) profile is crucial to establish a re-testing plan discharge ending isolation patients. We aimed evaluate number days that patient needed achieve undetectable levels SARS-CoV-2 in tract specimens (nasopharyngeal swab and/or an oropharyngeal swab). The persistence was...
Abstract Background Osteosarcoma is a bone-forming tumor of mesenchymal origin that presents clinical pattern consistent with the cancer stem cell model. Cells stem-like properties (CSCs) have been identified in several tumors and hypothesized as responsible for relative resistance to therapy relapses. In this study, we aimed identify characterize CSCs populations human osteosarcoma line explore their role responsiveness conventional therapies. Methods were isolated from MNNG/HOS using...
Abstract Nitric oxide (NO) was described to inhibit the proliferation of neural stem cells. Some evidence suggests that NO, under certain conditions, can also promote cell proliferation, although mechanisms responsible for a potential proliferative effect NO in cells have remained unaddressed. In this work, we investigated and characterized cultures obtained from mouse subventricular zone. We found donor NOC-18 (10 μM) increased whereas higher concentrations (100 inhibited proliferation....
Glioblastoma (GBM) is the most aggressive and malignant brain tumor. Recent studies indicated that glioma samples are characterized by increased expression of CXCR4, CXCL12/SDF-1 chemokine receptor. To better understand role CXCR4 in GBM biology we performed an integrated study where simultaneously evaluate contribution CXCR4/CXCL12 signaling pathway to proliferation, survival motility a human cell line. Our results axis induced increase proliferation motility. The blockage significant...
A contabilidade ambiental tem ganhado crescente relevância na gestão empresarial, impulsionada por demandas regulatórias e pressões dos stakeholders para maior transparência sustentabilidade. No entanto, sua implementação ainda enfrenta desafios relacionados à padronização, custos operacionais riscos como o greenwashing. Este estudo objetivo analisar a influência da no desempenho sustentável das empresas, meio de uma revisão sistemática literatura. Para isso, foram analisados 15 estudos...
A educação socioemocional (ESE) tem sido amplamente reconhecida como essencial para o desenvolvimento integral dos indivíduos, ultrapassando as habilidades cognitivas tradicionais. No entanto, sua implementação efetiva enfrenta desafios a falta de clareza conceitual, resistência institucional e capacitação docente insuficiente. pandemia da COVID-19 reforçou necessidade estratégias que integrem emocional cognitivo. Assim, este estudo objetivo analisar publicações científicas sobre ESE,...
Glioblastomas (GBM) are the most lethal subtype of astrocytomas, with a mean patient survival rate 12 months after diagnosis. The gold standard treatment GBM, which includes surgery followed by combination radiotherapy and chemotherapy temozolomide (TMZ), increases to 14.6 months. success TMZ appears be limited occurrence chemoresistance that allows glioma cells escape from death signaling pathways. However, mechanism action is yet clarified although some controversial results have been...
To evaluate short-term markers of outcome in diabetic macular edema (DME). Prospective interventional case series included 122 eyes patients with recently diagnosed DME. Eyes were treated a 3-monthly loading dose ranibizumab or aflibercept and pro re nata thereafter. Serial enhanced deep imaging SD-OCT high resolution scans used to measure subfoveal choroidal thickness (SFCT) central retinal (CRT). Anatomic (10% CRT decrease) functional responses (best corrected visual acuity, BCVA gain ≥5...
Background: Our previous results showed that in retinas from streptozotocin (STZ)‐induced diabetic rats there is an increased level of interleukin‐1β (IL‐1β ). This cytokine may be involved the expression inducible isoform nitric oxide synthase (iNOS), with consequent synthesis large amounts NO and blood–retinal barrier (BRB) breakdown. Aims: The aim this work was to examine whether administration cyclosporin‐A (Cs‐A) STZinduced inhibits IL‐1β proteins, iNOS cyclo‐oxygenase‐2 (COX‐2) retinal...
Glioblastoma (GBM) is a grade IV astrocytoma. GBM patients show resistance to chemotherapy such as temozolomide (TMZ), the gold standard treatment. In order simulate molecular mechanisms behind different chemotherapeutic responses in we compared cellular heterogeneity and cell lines. We isolated characterized human line obtained from patient, named GBM11. studied GBM11 behaviour when treated with Tamoxifen (TMX) that, among other functions, protein kinase C (PKC) inhibitor, alone combination...
The hepatocellular carcinoma, a primary malignancy of the liver, has very poor prognosis and lower survival rate. Moreover, inefficacy conventional therapies emphasizes importance discovering new bioactive compounds. Several studies clearly state that plant-derived polyphenols, namely ellagitannins, have several health benefits. Fragaria vesca leaves contain high amounts being especially rich in ellagitannins. Therefore, this study aimed to characterize an ellagitannin-enriched fraction...