A5047639632- Phytochemicals and Antioxidant Activities
- Autophagy in Disease and Therapy
- Essential Oils and Antimicrobial Activity
- Retinal Diseases and Treatments
- Phytochemistry and Biological Activities
- Advanced Glycation End Products research
- Bee Products Chemical Analysis
- Pomegranate: compositions and health benefits
- Tannin, Tannase and Anticancer Activities
- Microbial Metabolites in Food Biotechnology
- Neuroscience and Neuropharmacology Research
- COVID-19 Clinical Research Studies
- Barrier Structure and Function Studies
- Healthcare and Venom Research
- Traditional and Medicinal Uses of Annonaceae
- Cellular transport and secretion
- Fungal Biology and Applications
- Inflammasome and immune disorders
- Insect and Pesticide Research
- RNA Interference and Gene Delivery
- Synthesis of Organic Compounds
- Free Radicals and Antioxidants
- Natural product bioactivities and synthesis
- Retinal Development and Disorders
- Healthcare during COVID-19 Pandemic
Escola Superior de Tecnologia da Saúde de Coimbra
2024
Polytechnic Institute of Coimbra
2023-2024
University of Coimbra
2010-2023
Weatherford College
2022
Polytechnic Institute of Castelo Branco
2017-2022
Association for Innovation and Biomedical Research on Light and Image
2010-2017
Centro de Neurociências e Biologia Celular
2011
OBJECTIVE Calcium dobesilate (CaD) has been used in the treatment of diabetic retinopathy last decades, but its mechanisms action are not elucidated. CaD is able to correct excessive vascular permeability retina patients and experimental diabetes. We investigated molecular cellular underlying protective effects against increase blood–retinal barrier (BRB) induced by RESEARCH DESIGN AND METHODS Wistar rats were divided into three groups: controls, streptozotocin-induced rats, treated with...
Agrimony ( Agrimonia eupatoria L.) (Ae) is used in traditional medicine to treat inflammatory and oxidative related diseases. Therefore, this study focuses on the anti‐inflammatory analgesic potential of Ae infusion (AeI). Phenolic compounds characterization was achieved by HPLC‐PDA‐ESI/MS n . To evaluate antioxidant potential, 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical, SNAP assays were used. In vitro activity AeI investigated LPS‐stimulated macrophages...
Luteolin is a dietary flavonoid with medicinal properties including antioxidant, antimicrobial, anticancer, antiallergic, and anti-inflammatory. However, the effect of luteolin on liver X receptors (LXRs), oxysterol sensors that regulate cholesterol homeostasis, lipogenesis, inflammation, has yet to be studied. To unveil potential as an LXRα/β modulator, we investigated by real-time RT-PCR expression LXR-target genes, namely, sterol regulatory element binding protein 1c (SREBP-1c) in...
Abstract BACKGROUND Cymbopogon citratus (Cc), commonly known as lemongrass, is a very important crop worldwide, being grown in tropical countries. It widely used the food, pharmaceutical, cosmetic and perfumery industries for its essential oil. Cc aqueous extracts are also traditional medicine. They contain high levels of polyphenols, which their antioxidant anti‐inflammatory properties. Hydrodistillation lemongrass oil produces an waste ( CcHD ) discarded. Therefore comparative study...
Lavandulaviridis L´Hér. is an endemic Iberian species with a high essential oil yield and pleasant lemon scent. Despite these interesting features, this remains unrecognized poorly explored by the food pharmaceutical industries. Nevertheless, it has been valued in traditional medicine being used against flu, circulatory problems to relieve headaches. Since disorders trigger inflammatory responses, relevant determine anti-inflammatory potential of L. viridis attempt validate its use...
The hepatocellular carcinoma, a primary malignancy of the liver, has very poor prognosis and lower survival rate. Moreover, inefficacy conventional therapies emphasizes importance discovering new bioactive compounds. Several studies clearly state that plant-derived polyphenols, namely ellagitannins, have several health benefits. Fragaria vesca leaves contain high amounts being especially rich in ellagitannins. Therefore, this study aimed to characterize an ellagitannin-enriched fraction...
Calcium dobesilate (CaD) has been prescribed to some patients in the early stages of diabetic retinopathy delay its progression. We previously reported that treatment animals (4 weeks diabetes) with CaD, during last 10 days diabetes, prevents blood-retinal barrier breakdown. Here, we aimed investigate whether later rats CaD would reverse inflammatory processes retina. Diabetes was induced streptozotocin, and 6 after diabetes onset, (100 mg/kg/day) administered for 2 weeks. The significantly...
Multiple factors, from socioeconomic development to genetic background, can affect the regional impact of some diseases, and this has also been seen during COVID-19 pandemic. The objective retrospective study was characterize a population in interior Portugal regarding health status epidemiology. Between October 2021 January 2023, 1553 subjects residing Beira Baixa, Portugal, were included. Using self-report approach, demographic clinical data obtained. Blood group, blood pressure,...
A new C15-acetogenin, sagonenyne (20), exhibiting an unusual single tetrahydropyran ring was isolated from ethyl acetate extract of Laurencia obtusa collected on the Corsican coastline. Its structure established by detailed NMR spectroscopic analysis, mass spectrometry, and comparison with literature data. Twenty-three known compounds were identified in same means column chromatography steps, using a 13C-NMR computer aided method developed our laboratory. In addition to sesquiterpenes, which...
Alzheimer´s disease is a neurodegenerative and the most common cause of dementia with no cure or treatment. Therefore, investigation to find disease-modifying therapeutic crucial. From pathophysiological point view, AD characterized by loss homeostatic functions that control redox energy metabolism, neuroinflammation, proteostasis. The transcription factor nuclear erythroid 2–related 2 (Nrf2) master controller these and, in past decades, recent reports have shown its overall activity...