A5112412370- Breastfeeding Practices and Influences
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Indigenous Health and Education
- Curcumin's Biomedical Applications
- Obesity, Physical Activity, Diet
- Natural Antidiabetic Agents Studies
- Biochemical effects in animals
- Cytokine Signaling Pathways and Interactions
- Nutritional Studies and Diet
- RNA Research and Splicing
- Glutathione Transferases and Polymorphisms
- Cell death mechanisms and regulation
- Aluminum toxicity and tolerance in plants and animals
- Protein Kinase Regulation and GTPase Signaling
- RNA modifications and cancer
Hospital de Clínicas da Unicamp
2025
University of Coimbra
2023-2024
Universidade Federal de São Paulo
2024
Universidade Federal Fluminense
2020
SUMMARY PTK2, a non-receptor tyrosine kinase, is essential for regulating pivotal cellular functions, including survival by reducing p53 levels and activating PI3K/AKT pathway. However, the mechanism underlying PTK2 stabilization during stress remained unclear. Here, we identified Bclaf1, multifunctional protein known to stabilize partners, as interactor. Using advanced microscopy techniques, nuclear Bclaf1 biomolecular condensates containing in cardiomyocytes under oxidative stress. While...
Curcumin has been proposed as a potential treatment for Alzheimer's disease (AD) due to its ability inhibit amyloid-β (Aβ) peptide aggregates and destabilise pre-formed ones. Derivative 27 was synthesized improve low-dose efficacy in the context of AD. Its anti-inflammatory, antioxidant anti-amyloidogenic activities were evaluated chemico, vitro using AD neuroinflammation cell models, vivo double-transgenic APP/PS1 mice. In vitro, this curcumin derivative significantly reduced nitric oxide...
Alzheimer´s disease is a neurodegenerative and the most common cause of dementia with no cure or treatment. Therefore, investigation to find disease-modifying therapeutic crucial. From pathophysiological point view, AD characterized by loss homeostatic functions that control redox energy metabolism, neuroinflammation, proteostasis. The transcription factor nuclear erythroid 2–related 2 (Nrf2) master controller these and, in past decades, recent reports have shown its overall activity...
The aim of this study was to investigate the relationship between food consumption 99 pregnant women aged 16-44 years who gave birth at a maternity hospital in Rio de Janeiro and newborn weight. Maternal unprocessed or minimally processed ultra-processed foods evaluated through Food Consumption Markers Form. For foods, most regularly consumed sweets (73.7%), soft drinks (71.7%), sausages (65.7%), salted crackers (63.6%) fried (55.6%). Among beans (85.9%) milk yogurt (60.6%), while less than...