A5069878877- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Ocular Oncology and Treatments
- Retinal Diseases and Treatments
- Cutaneous Melanoma Detection and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Drug-Induced Ocular Toxicity
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Ocular Infections and Treatments
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Tuberculosis Research and Epidemiology
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Children's Physical and Motor Development
- Dermatological diseases and infestations
- Parasitic Infections and Diagnostics
- Sarcoidosis and Beryllium Toxicity Research
- Syphilis Diagnosis and Treatment
- Vasculitis and related conditions
- Medicine and Dermatology Studies History
Portuguese Air Force Academy
2024-2025
Hospitais da Universidade de Coimbra
1994-2024
Escola Superior de Tecnologia da Saúde de Coimbra
2023
University of Coimbra
2007-2022
McGill University
2018
Hospital de Egas Moniz
2016
Johns Hopkins University
2006
Universidade do Porto
2005
Hospital Curry Cabral
1974-2004
The Royal Free Hospital
2000
Objectives: To describe changes in haemoglobin over time and to determine the joint prognostic value of current haemoglobin, CD4 lymphocyte count viral load among patients from across Europe. Patients: The analysis included 6725 EuroSIDA, an observational, prospective cohort with HIV Methods: Normal was defined as greater than 14g/dl for men 12g/dl women; mild anaemia 8-14g/dl 8-12g/dl severe less 8g/dl both males females. Linear regression techniques were used estimate annual change...
The impact of highly active antiretroviral therapy (HAART) among human immunodeficiency virus (HIV)-infected patients on the incidences mycobacterial infections has not been studied in detail. We assessed diseases HIV- infected following introduction HAART, using data from EuroSIDA study, a European, multicenter observational cohort more than 7,000 patients. Overall Mycobacterium tuberculosis (TB) and avium complex (MAC) were 0.8 1.4 cases/100 person-years follow-up (PYF), decreasing 1.8 3.5...
Nerve growth factor (NGF) is a neuropeptide essential for the development, survival, growth, and differentiation of corneal cells. Its effects are mediated by both TrkA p75 receptors. Clinically relevant use NGF was introduced to treat neurotrophic ulcerations in patients. Herein, we examine mechanisms which enhances epithelial wound healing vivo vitro.An animal model using adult hens implemented experiments. Laser ablation keratectomy performed animals were observed up 7 days. Epithelial...
Introduction: To report the first case of a serpiginous choroiditis presenting after SARS-CoV-2 infection in previously healthy young woman. Case description: A 41-year-old woman reported blurry vision OS 1 month mild infection. Left eye fundus examination revealed multiple peripapillary atrophic lesions, adjacent to larger diffuse, ill-defined, yellow-whitish deep amoeboid-like patch, involving region and extending temporally fovea. Multimodal imaging including fluorescein angiography,...
Travassos, Ana S. MD; Regadas, Isaura Alfaiate, Mário Silva, Eduardo D. PhD; Proença, Rui António MDEditor(s): Williams, George A. Author Information
Objective The “Super Quinas” project evaluated the effectiveness of an intervention program to improve physical activity, aerobic fitness, sleep, and motor competence on children in primary school. Methods experimental group ( n = 19) enrolled a 12-week (one more extra-curricular activity class 60 min per week) compared CG 19), all aged 9–10 years. Physical (PA) sleep were measured by accelerometry, fitness was Children’s Yo-Yo test (YYIR1C) during 1st week (PRE), 6th (DUR), 12th (POST)...
This study evaluated the one-year impact of a 12-week school-based physical activity (PA) intervention, which added one extra hour structured PA per week, on children's movement behaviors, aerobic fitness, and motor competence (MC). A longitudinal comparison between an experimental group (EG) control (CG) was conducted at baseline (PRE), mid-intervention (DUR), post-intervention (POST), follow-up (FUP). The in single school without randomization. Movement behaviors (accelerometry), fitness...
Epiretinal membrane (ERM) is an eye disease that affects 7% of the world population, with a higher incidence in people over 75 years old. If left untreated, it can lead to complications central vision, resulting severe vision loss. Early detection important for progress follow-up, treatment monitoring, and avoid total Optical coherence tomography, non-invasive retina imaging technique, be used effective monitoring this condition. To date, automatic methods detect ERM have received little...
Mitochondrial DNA (mtDNA) genotypes were determined for Atlantic striped bass from the St. Johns River in northeastern Florida and several hatchery reared individuals Monck's Corner, South Carolina. Adults hatchery-reared descendants of with high lateral line scale counts sampled sites Apalachicola system along Gulf coast Florida. In addition, naturally reproduced 1985 year class juveniles sampled. All mtDNA compared those observed our sample approximately 200 fish coastal migratory stock....
To evaluate ocular involvement in a cohort of systemic lupus erythematosus (SLE) patients tertiary referral center and to compare the results with existing literature.Patients underwent complete ophthalmological evaluation, including visual acuity, slit-lamp examination, fluorescein staining, Schirmer-I test, Goldmann applanation tonometry, fundoscopy, 10-2 automated threshold fields, fundus autofluorescence spectral-domain optical coherence tomography screen for hydroxychloroquine (HCQ)...
To compare choroidal thickness (CT) between patients with systemic lupus erythematosus (SLE) without ophthalmologic manifestations and a control group. study the effects in CT of disease duration, activity index, medication comorbidities.Cross-sectional where spectral-domain optical coherence tomography enhanced depth imaging was used to measure 13 locations, subfoveally at 500-µm intervals along horizontal vertical section from fovea. Linear regression models were used.Sixty-eight SLE fifty...
Systemic lupus erythematosus (SLE) is a chronic, autoimmune and multisystemic disease. Recent studies with functional structural magnetic resonance imaging cognitive tests report an unexpectedly high frequency of central nervous system involvement, even in patients asymptomatic SLE. The purpose this study was to identify early signs retinal neurodegeneration by comparing the thickness peripapillary nerve fiber layer (pRNFL) all macular layers between SLE without ophthalmologic manifestations...
Uveal melanoma (UM) is the most frequent primary ocular cancer in adults, accounting for 5% of all melanomas. Despite effective treatments tumour, up to 50% UM patients will develop metastasis, leading a very poor prognosis and median overall survival 6 12 months, with no major improvements last 30 years. There standard oncological treatment available metastatic patients, BRAF/MEK immune checkpoint inhibitors show disappointing results when compared cutaneous (CM). Recent advances biology,...
A 17-year-old man presented to the emergency department with complaints of retro-orbital pain left eye and an altitudinal visual field defect for 2 weeks. Fundus examination revealed ipsilateral hyperaemic optic disc oedema, patient was admitted presumptive diagnosis neuritis. Subsequently, during follow-up, developed a retinal granulomatous lesion in superior temporal arcade vitritis fibrotic strands extending mid-periphery. Serum antibodies detection by ELISA aqueous humour immunoblot were...
The authors report a case of an orbital metastasis from occult breast carcinoma. A 66-year-old woman presented with growing left tumour. Orbital CT scan was consistent lymphoma. However, ocular pathology revealed small neoplastic cells showing 'indian file pattern' suggestive metastatic carcinoma and immunohistochemistry positive for CK7, CK CAM5.2 oestrogen receptor. systemic evaluation then performed mammogram, ultrasound MRI considered normal. An exhaustive multiple bone lesions, right...