A5022065316- Dental Radiography and Imaging
- Dental Implant Techniques and Outcomes
- Medical Imaging Techniques and Applications
- Cleft Lip and Palate Research
- Orthodontics and Dentofacial Orthopedics
- Temporomandibular Joint Disorders
- Craniofacial Disorders and Treatments
- Endodontics and Root Canal Treatments
- Oral microbiology and periodontitis research
- Dental materials and restorations
- Dental Health and Care Utilization
- Radiomics and Machine Learning in Medical Imaging
- Plasma Applications and Diagnostics
- Advanced X-ray and CT Imaging
- dental development and anomalies
- Periodontal Regeneration and Treatments
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer-related gene regulation
- Head and Neck Cancer Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Anatomy and Medical Technology
- Dental Research and COVID-19
- Dental Anxiety and Anesthesia Techniques
- Optical Coherence Tomography Applications
University of Coimbra
2016-2025
Escola Superior de Tecnologia da Saúde de Coimbra
2021-2024
Hospitais da Universidade de Coimbra
2017-2023
Czech Academy of Sciences, Institute of Biophysics
2023
Controle & Inspectie Bureau Brouwer (Netherlands)
2023
Escola Superior de Saúde Egas Moniz
2017-2022
Sociedade Portuguesa de Cardiologia
2022
Medicina
2022
John Wiley & Sons (United States)
2020
Hudson Institute
2020
The goal of this exploratory study was to develop and assess a prediction model which can potentially be used as biomarker breast cancer, based on anthropometric data parameters gathered in routine blood analysis. For each the 166 participants several clinical features were observed or measured, including age, BMI, Glucose, Insulin, HOMA, Leptin, Adiponectin, Resistin MCP-1. Machine learning algorithms (logistic regression, random forests, support vector machines) implemented taking...
Abstract Since late December 2019 a new epidemic outbreak has emerged from Whuhan, China. Rapidly the coronavirus spread worldwide. China CDC reported results of descriptive exploratory analysis all cases diagnosed until 11th February 2020, presenting epidemiologic curves and geo-temporal COVID-19 along with case fatality rate according to some baseline characteristics, such as age, gender several well-established high prevalence comorbidities. Despite this, we intend increase even further...
Abstract COVID-19 is having a great impact on public health, mortality and economy worldwide, in spite of the efforts to prevent its epidemy. The SARS-CoV-2 genome different from that MERS-CoV SARS-CoV, although also expected spread differently according meteorological conditions. Our main goal investigate role some variables expansion this outbreak. In study, an exponential model relating number accumulated confirmed cases time was considered. rate spread, using as criterion doubling cases,...
Abstract Background Bariatric surgery is the most long-term effective treatment option for severe obesity. The role of gut microbiome (GM) in either development obesity or response to management strategies has been a matter debate. This study aims compare impact two popular procedures, sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (GB), on metabolic syndrome parameters bacterial systemic immuno-inflammatory response. Methods A prospective observational enrolled 24 patients with...
Endodontic biofilms eradication from the infected root canal system remains as primary focus in endodontic field. In this study, it was assessed efficacy of antimicrobial Photodynamic Therapy (aPDT) with Zn(II)chlorin e6 methyl ester (Zn(II)e6Me) activated by red light against monospecies and mixed Enterococcus faecalis Candida albicans. The results were compared ones obtained Rose Bengal (RB), Toluidine Blue-O (TBO), synthetic tetracationic porphyrin (TMPyP) well classical irrigants (3%...
Tear fluid biomarkers may offer a non-invasive strategy for detecting diabetic patients with increased risk of developing retinopathy (DR) or disease progression, thus helping both improving diagnostic accuracy and understanding the pathophysiology disease. Here, we assessed tear nondiabetic individuals, no DR, nonproliferative DR (NPDR) proliferative (PDR) to find putative diagnosis staging DR.Tear samples were collected using Schirmer test strips from cohort 12 controls 54 Type 2 Diabetes...
The aim of the present ex vivo study was to assess and compare coronal discoloration induced by four endodontic biomaterials used in regenerative procedures (REPs). Root resection executed horizontally, 2 mm apical cementoenamel junction, all fifty-four teeth. After accessing pulp chamber, specimens were randomly divided groups filled with either saline solution or blood, followed calcium silicate-based cements (CSCs) placement: ProRoot mineral trioxide aggregate (MTA) (Dentsply Sirona),...
Background and Objectives: Temporomandibular joint disorders (TMJDs) are associated with pain reduced jaw mobility. The aim of this study was to compare the outcome patients TMJ arthralgia when submitted four different treatment modalities, in some cases using intra-articular injections substances anti-inflammatory properties others, a more conservative approach consisting only bite splint. Materials Methods: sample made up 80 patients, randomly distributed into 4 groups 20 each. Each...
Collagenated porcine-derived bone graft materials exhibit osteoconductive properties and the development of different formulations intends to enhance regeneration. This study aims evaluate healing in a rabbit cancellous defect response grafting with physicochemical forms heterologous porcine bone. Twenty-six adult male New Zealand White rabbits received two critical size femoral defects per animal (n = 52), each randomly assigned one five tested (Apatos, Gen-Os, mp3, Putty, Gel 40). Animals...
Breast cancer (BC) is a malignant neoplasia with the highest incidence and mortality rates in women worldwide. Currently, therapies include surgery, radiotherapy, chemotherapy, including targeted some cases. However, treatments are often associated serious adverse effects. Looking for new options BC treatment, we evaluated therapeutic potential of cold atmospheric plasma (CAP) two cell lines (MCF7 HCC1806) distinct histological features. Apoptosis seemed to be most prevalent type death, as...
Classically associated with gap junction-mediated intercellular communication, connexin43 (Cx43) is increasingly recognized to possess non-canonical biological functions, including gene expression regulation. However, the mechanisms governing localization and role played by Cx43 in nucleus, namely transcription modulation, remain unknown. Using comprehensive complementary approaches encompassing biochemical assays, super-resolution immunogold transmission electron microscopy, we demonstrate...
ABSTRACT Introduction Patients with non‐immediate hypersensitivity to beta‐lactam antibiotics (βL) often avoid all βL, limitations for future therapy. Objectives Assess cross‐reactivity between βL in cutaneous adverse drug reactions (ni‐CADRs). Methods Retrospective analysis (2000–2022) of patients suspected ni‐CADR as a possible culprit who underwent patch testing (PT) an extended antibiotic series (10% pet., Chemotechnique Diagnostics or prepared in‐house) according European Society...
ABSTRACT Objective To evaluate the effects of four endodontic irrigation protocols on chemical composition and ultrastructure coronal dentin. Materials Methods Coronal dentin fragments were assigned to five study groups: NaOCl (3% sodium hypochlorite), NaOCl/EDTA 17% ethylenediaminetetraacetic acid), NaOCl/EDTA/CHX NaOCl, EDTA 2% chlorhexidine), NaOCl/HEDP (mixture 3% 9% etidronic control (distilled water). Confocal Raman microscopy was employed analyze spatial distribution organic inorganic...
Background The optimal immunosuppressive (IS) withdrawal strategy after kidney allograft failure remains unclear. This study evaluated the effects of prolonged calcineurin inhibitor (CNI) therapy on HLA sensitization, graft intolerance syndrome (GIS), and key clinical outcomes.
Abstract The head and neck squamous cell carcinoma (HNSCC) population consists mainly of high-risk for recurrence locally advanced stage patients. Increased knowledge the HNSCC genomic profile can improve early diagnosis treatment outcomes. development models to identify consistent patterns that distinguish patients will recur and/or develop metastasis after is utmost importance decrease mortality survival rates. In this study, we used array comparative hybridization data from implement a...