A5038080240- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Infective Endocarditis Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Cardiovascular Effects of Exercise
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac tumors and thrombi
- Pericarditis and Cardiac Tamponade
- Mitochondrial Function and Pathology
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical industry and healthcare
- Cardiovascular Disease and Adiposity
- Meta-analysis and systematic reviews
University of Coimbra
2016-2025
Hospitais da Universidade de Coimbra
2016-2025
Universidade Federal do Oeste do Pará
2024
Hospital do Mar
2024
Association for Innovation and Biomedical Research on Light and Image
2021-2024
Université Paris Cité
2024
Hôpital Lariboisière
2024
Sociedade Portuguesa de Cardiologia
2013-2023
Hospital Universitario La Paz
2023
Escola Superior de Tecnologia da Saúde de Coimbra
2020-2023
The universal definition of myocardial infarction (MI) classifies acute ischaemia into different classes according to lesion mechanism. Our aim was perform a detailed comparison between these types MI in terms baseline characteristics, management and prognosis.An observational retrospective single-centre cohort study performed, including 1,000 consecutive patients admitted for type 1 (76.4%) or 2 (23.6%). Type were older, had higher prevalence comorbidities worse medical status at admission....
Heart rate variability (HRV) represents one of the most promising markers autonomic nervous system (ANS) regulation. However, it requires acquisition ECG signal in order to reliably detect RR intervals, which is not always easily and comfortably available personal health applications. Additionally, due progress single spot optical sensors, photoplethysmography (PPG) an interesting alternative for heartbeat interval measurements, since a more convenient less intrusive measurement technique....
AMPK activation during ischemia helps the myocardium to cope with deficit of energy production. As activity is considered be impaired in diabetes, we hypothesized that enhancing above physiological levels would protect ischemic diabetic heart through and subsequent inhibition mitochondrial permeability transition pore (mPTP) opening. Isolated perfused hearts from normoglycemic Wistar or Goto-Kakizaki (GK) rats ( n ≥ 6/group) were subjected 35 min presence 10, 20, 40 μM A-769662, a known...
Some patients show such an important clinical improvement and reverse remodelling after cardiac resynchronization therapy (CRT) that anatomy function approach normal. These have been called 'super-responders'. The aim of our study was to identify predictors becoming a super-responder CRT. Eighty-seven consecutive who underwent CRT were prospectively studied. Before 6 months after, echocardiographic evaluation performed. Patients with decrease in New York Heart Association functional class...
The previous Core Curriculum for the General Cardiologist defined a model cardiology training in Europe and it has been adopted as standard regulating training, access to specialty (certification), revalidation several countries.1 During last 5 years we have witnessed profound changes cardiological practice. work of both hospital independent cardiologists better integrated with that general practitioners. It taken into account requirements national authorities, re-imbursement organizations,...
Metformin improves cardiovascular outcomes in patients with type 2 diabetes compared other glucose-lowering drugs. Experimental studies have shown that metformin can increase the intracellular concentration of adenosine monophosphate, which is a major determinant formation adenosine. We hypothesize metformin, given at reperfusion, limit myocardial infarct size due to increased receptor stimulation. Isolated perfused hearts from Sprague-Dawley rats were subjected 35 minutes regional ischemia...
Diabetic patients have a significantly worse prognosis after an acute myocardial infarction (AMI) than their counterparts. Previous studies shown that the number of circulating endothelial progenitor cells (EPCs) increase early AMI in normoglycemic patients. However, it is well known type 2 diabetes mellitus (DM) associated with impaired function and reduced EPCs levels. Nonetheless, few analyzed response diabetics to EPC pre-diabetic has not been reported yet. Therefore, we hypothesized...
Rationale: Efficient communication between heart cells is vital to ensure the anisotropic propagation of electrical impulses, a function mainly accomplished by gap junctions (GJ) composed Cx43 (connexin 43). Although molecular mechanisms remain unclear, altered distribution and have been associated with acute myocardial infarction failure. Objective: A recent proteomic study from our laboratory identified EHD1 (Eps15 [endocytic adaptor epidermal growth factor receptor substrate 15] homology...
Classically associated with gap junction-mediated intercellular communication, connexin43 (Cx43) is increasingly recognized to possess non-canonical biological functions, including gene expression regulation. However, the mechanisms governing localization and role played by Cx43 in nucleus, namely transcription modulation, remain unknown. Using comprehensive complementary approaches encompassing biochemical assays, super-resolution immunogold transmission electron microscopy, we demonstrate...
Rotational atherectomy (RA) is widely used for the management of calcified coronary stenoses. However, there limited data on its use, trends, and outcomes. We sought to report our twelve-year experience with RA explore trends outcomes percutaneous intervention (PCI) this device. Our institutional PCI database was queried identify all cases RA-PCI performed between January 2009 December 2020. analysed peri-procedural major adverse cardiovascular events (MACE) during follow-up: death,...