A5068152389- Schizophrenia research and treatment
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Treatment and Access
- Psychosomatic Disorders and Their Treatments
- Obsessive-Compulsive Spectrum Disorders
- Tryptophan and brain disorders
- Treatment of Major Depression
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Diet and metabolism studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health and Patient Involvement
- Electroconvulsive Therapy Studies
- Psychiatric care and mental health services
- Adolescent and Pediatric Healthcare
- Family Caregiving in Mental Illness
- Health Systems, Economic Evaluations, Quality of Life
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Digital Mental Health Interventions
- Cannabis and Cannabinoid Research
The University of Melbourne
2016-2025
Orygen
2006-2025
Orygen Youth Health
2014-2024
Copenhagen University Hospital
2023
Park Centre for Mental Health
2023
Ludwig-Maximilians-Universität München
2023
University Hospital Cologne
2021
University of Cologne
2021
Mental Health Australia
2014-2020
Monash University
2005-2020
Personalized medicine is rapidly becoming a reality in today's physical medicine. However, as yet this largely an aspirational goal psychiatry, despite significant advances our understanding of the biochemical, genetic and neurobiological processes underlying major mental disorders. Preventive relies on availability predictive tools; psychiatry we still lack these. Furthermore, current diagnostic systems, with their focus well-established, chronic illness, do not support pre-emptive, let...
The role of nutrition in mental health is becoming increasingly acknowledged. Along with dietary intake, can also be obtained from “nutrient supplements”, such as polyunsaturated fatty acids (PUFAs), vitamins, minerals, antioxidants, amino and pre/probiotic supplements. Recently, a large number meta‐analyses have emerged examining nutrient supplements the treatment disorders. To produce meta‐review this top‐tier evidence, we identified, synthesized appraised all randomized controlled trials...
Abstract This article describes the rationale, aims, and methodology of Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). is largest international collaboration to date that will develop algorithms predict trajectories outcomes individuals at clinical high risk (CHR) for psychosis advance development use novel pharmacological interventions CHR individuals. We present a description participating research networks data processing analysis coordination center, their processes...
Abstract Lithium and quetiapine are effective treatments for bipolar disorder, but their potential neuroprotective effects in humans remain unclear. A single blinded equivalence randomized controlled maintenance trial was conducted a prospective cohort of first-episode mania (FEM) patients ( n =26) to longitudinally compare the putative protective lithium quetapine on grey white matter volume. healthy control sample also collected =20). Using structural MRI scans, voxel-wise volumes at...
Changes in brain volume are a common finding Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous longitudinal suggest that deficits progress illness duration. However, major unresolved question concerns whether these changes driven by the underlying or represent iatrogenic effects antipsychotic medication. In this study, 62 antipsychotic-naïve patients first-episode (FEP) received either second-generation (risperidone paliperidone) placebo pill over treatment...
Psychotic illness is associated with anatomically distributed gray matter reductions that can worsen progression, but the mechanisms underlying specific spatial patterning of these changes unknown.
Abstract Modern research management, particularly for publicly funded studies, assumes a data governance model in which grantees are considered stewards rather than owners of important sets. Thus, there is an expectation that collected shared as widely possible with the general community. This presents problems complex studies involve sensitive health information. The latter requires balancing participant privacy needs Here, we report on operation ecosystem crafted Accelerating Medicines...
The ACE project involved 62 participants with a first episode of psychosis randomly assigned to either cognitive behaviour therapy (CBT) intervention known as Active Cognitive Therapy for Early Psychosis (ACE) or control condition Befriending. study hypotheses were that: (1) treating in the acute phase would lead faster reductions positive and negative symptoms more rapid improvement functioning than Befriending; (2) these improvements be sustained at 1-year follow-up; (3) fewer...
Background High unemployment is a hallmark of psychotic illness. Individual placement and support (IPS) may be effective at assisting the vocational recoveries young people with first-episode psychosis (FEP). Aims To examine effectiveness IPS FEP to gain employment (Australian Clinical Trials Registry ACTRN12608000094370). Method Young ( n = 146) who were interested in recovery randomised using computer-generated random permuted blocks on 1:1 ratio to: (a) 6 months addition treatment as...
Abstract This triple-blind (participants, clinicians, and researchers) randomized controlled noninferiority trial examined whether intensive psychosocial intervention (cognitive-behavioral case management, CBCM) for first-episode psychosis (FEP) in 15–25 year-olds managed a specialized early service was noninferior to usual treatment of antipsychotic medication plus CBCM delivered during the first 6 months treatment. To maximize safety, participants were required have low levels suicidality...
Altered functional connectivity (FC) is a common finding in resting-state magnetic resonance imaging (rs-fMRI) studies of people with psychosis, yet how FC disturbances evolve the early stages illness, and antipsychotic treatment influences these disturbances, remains unknown.To investigate longitudinal changes antipsychotic-naive antipsychotic-treated patients first-episode psychosis (FEP).This secondary analysis triple-blind, randomized clinical trial was conducted over 5-year recruitment...
Abstract Aim To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome psychosis (CHR‐P): Structured Interview Psychosis‐risk Syndromes (SIPS) Comprehensive Assessment of At‐Risk Mental States (CAARMS). Methods The initial workshop is described in companion report from Addington et al. After workshop, lead experts each instrument continued harmonizing attenuated positive symptoms criteria CHR‐P through an intensive series joint...
Abstract Aim: The study aims to investigate affect recognition in young people at different stages of psychotic illness. Methods: Seventy‐nine ultra‐high risk patients, 30 first‐episode schizophrenia patients and healthy control subjects completed a facial labelling test an affective prosody test. Psychiatric symptoms were assessed using the Positive Negative Syndrome Scale (PANSS). Results: We observed significant impairments vocal emotion both clinical groups compared with group. These...
To identify cognitive subgroups (comprising neurocognition and social cognition domains) within first-episode psychosis (FEP) patients including a healthy control group for comparison. Predictive validity of clusters in relation to symptoms functioning was also investigated.A comprehensive battery administered 133 FEP participants 46 controls. Ward's method hierarchical agglomerative cluster analysis with k-means verification used determine clusters. Clusters were externally validated...