A5056482318- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Mental Health Treatment and Access
- Diet and metabolism studies
- Psychosomatic Disorders and Their Treatments
- Tryptophan and brain disorders
- Fatty Acid Research and Health
- Obsessive-Compulsive Spectrum Disorders
- Digital Mental Health Interventions
- Autism Spectrum Disorder Research
- COVID-19 and Mental Health
- Cannabis and Cannabinoid Research
- Advanced Neuroimaging Techniques and Applications
- Psychiatric care and mental health services
- Resilience and Mental Health
- Alcoholism and Thiamine Deficiency
- Personality Disorders and Psychopathology
- Treatment of Major Depression
- Maternal Mental Health During Pregnancy and Postpartum
- Health disparities and outcomes
- Psychological Well-being and Life Satisfaction
Amsterdam University Medical Centers
2018-2025
University of Amsterdam
2015-2025
Amsterdam UMC Location University of Amsterdam
2014-2024
University of Zurich
2024
Charité - Universitätsmedizin Berlin
2022
Amsterdam Neuroscience
2016
Royal Netherlands Academy of Arts and Sciences
2015
Netherlands Institute for Neuroscience
2015
Amsterdam Institute for Addiction Research
2011
The Health Council of the Netherlands
2011
In order to bring about implementation of routine screening for psychosis risk, a brief version the Prodromal Questionnaire (PQ; Loewy et al., 2005) was developed and tested in general help-seeking population. We assessed consecutive patient sample 3533 young adults who were nonpsychotic disorders at secondary mental health services Hague with PQ. performed logistic regression analyses CHi-squared Automatic Interaction Detector decision tree analysis shorten original 92 items. Receiver...
A promising treatment to prevent onset and improve outcomes in patients at ultrahigh risk for psychosis is dietary supplementation with long-chain ω-3 polyunsaturated fatty acids (PUFAs).To determine whether PUFAs combination a high-quality psychosocial intervention (cognitive behavioral case management [CBCM]) more effective than placebo plus CBCM.NEURAPRO, double-blind, placebo-controlled, randomized clinical trial, was conducted from March 1, 2010, September 30, 2014, 10 specialized early...
: Evidence for the effectiveness of treatments subjects at ultrahigh risk (UHR) developing psychosis remains inconclusive.Objective: A new cognitive behavioral intervention specifically targeted biases (ie, Cognitive Behavioral Therapy [CBT] UHR patients plus treatment as usual [TAU] called CBTuhr) is compared with TAU in a group young help-seeking subjects.Methods: total 201 were recruited 4 sites and randomized. In most cases, CBTuhr was an add-on therapy because people seeking help...
Background Subjects at ‘ultra high risk’ (UHR) for developing psychosis have differences in white matter (WM) compared with healthy controls. WM integrity has not yet been investigated UHR subjects relation to the development of subsequent psychosis. Hence, we a prospective cohort comparing whole brain fractional anisotropy (FA) those later (UHR-P) who did (UHR-NP). Method We recruited 37 fulfilling criteria and 10 Baseline 3 Tesla magnetic resonance imaging (MRI) scans Positive Negative...
Background. Deep brain stimulation (DBS) is a promising new treatment for patients with treatment-refractory obsessive–compulsive disorder (OCD). However, since most DBS only show partial response, the still needs to be improved. In this study we hypothesized that cognitive–behavioural therapy (CBT) could optimize post-operative management in and evaluated efficacy of CBT as augmentation targeted at nucleus accumbens. Method. A total 16 OCD were treated After stabilization decline symptoms,...
Background Decline in social functioning occurs individuals who later develop psychosis. Aims To investigate whether baseline differences disability are present those do and not make a transition to psychosis group clinically at high risk is factor for transition. Method Prospective multicentre, naturalistic field study with an 18-month follow-up period on 245 help-seeking risk. Disability was assessed the Assessment Schedule of World Health Organization (WHODAS–II). Results At baseline,...
Dragt S, Nieman DH, Schultze‐Lutter F, van der Meer Becker H, de Haan L, Dingemans PM, Birchwood M, Patterson P, Salokangas RKR, Heinimaa Heinz A, Juckel G, Graf von Reventlow French Stevens Ruhrmann Klosterkötter J, Linszen on behalf of the EPOS group. Cannabis use and age at onset symptoms in subjects clinical high risk for psychosis. Objective: Numerous studies have found a robust association between cannabis Nevertheless, relationship early (or, retrospect, prodromal) psychosis remains...
Background Cognitive impairment is considered to be a core characteristic of schizophrenia. The relationship between psychosis and cognitive deterioration, however, remains unclear. This longitudinal study investigated the neuropsychological functioning patients before after their first psychotic episode. participants who later developed was compared that people at ultra-high risk (UHR) for did not develop follow-up healthy controls. Method Participants were 41 persons UHR (the group), whom...
Background: The period preceding the first psychotic episode is regarded as a promising for intervention. We aimed to develop an optimized prediction model of psychosis, considering different sources information. outcome this may be used individualized risk estimation. Methods: Sixty-one subjects clinically at high (CHR), participating in Dutch Prediction Psychosis Study, were assessed baseline with instruments yielding data on neuropsychology, symptomatology, environmental factors,...
Rietdijk J, Klaassen R, Ising H, Dragt S, Nieman DH, van de Kamp Cuijpers P, Linszen D, der Gaag M. Detection of people at risk developing a first psychosis: comparison two recruitment strategies. Objective: Better strategies are needed to improve the identification ultra‐high psychosis. This study explores effectiveness strategies: screening method in consecutive help‐seeking population entering secondary mental health services for non‐psychotic problems vs. referred diagnostic center an...
Previously, we demonstrated that cognitive behavior therapy for ultra-high risk (called CBTuhr) halved the incidence of psychosis over an 18-month period. Follow-up data from same study are used to evaluate longer-term effects at 4 years post-baseline. The Dutch Early Detection and Intervention Evaluation was a randomized controlled trial 196 UHR patients comparing CBTuhr with treatment-as-usual (TAU) comorbid disorders TAU only. Of original patients, 113 consented 4-year follow-up (57.7%; =...