A5046183071- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Advanced Neuroimaging Techniques and Applications
- Adolescent and Pediatric Healthcare
- Advanced MRI Techniques and Applications
- Mental Health Research Topics
- Electroconvulsive Therapy Studies
- Schizophrenia research and treatment
- Mental Health Treatment and Access
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Psychosomatic Disorders and Their Treatments
- Neural dynamics and brain function
- Mental Health and Psychiatry
- Eosinophilic Esophagitis
- Child Nutrition and Feeding Issues
- Neurological disorders and treatments
- Stuttering Research and Treatment
- Psychiatric care and mental health services
- Health and Well-being Studies
Melbourne Health
2020-2021
The University of Melbourne
2020-2021
Orygen
2021
Monash University
2006-2020
Monash Alfred Psychiatry Research centre
2006-2007
The Alfred Hospital
2006-2007
Monash Health
2005
Changes in brain volume are a common finding Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous longitudinal suggest that deficits progress illness duration. However, major unresolved question concerns whether these changes driven by the underlying or represent iatrogenic effects antipsychotic medication. In this study, 62 antipsychotic-naïve patients first-episode (FEP) received either second-generation (risperidone paliperidone) placebo pill over treatment...
Altered functional connectivity (FC) is a common finding in resting-state magnetic resonance imaging (rs-fMRI) studies of people with psychosis, yet how FC disturbances evolve the early stages illness, and antipsychotic treatment influences these disturbances, remains unknown.To investigate longitudinal changes antipsychotic-naive antipsychotic-treated patients first-episode psychosis (FEP).This secondary analysis triple-blind, randomized clinical trial was conducted over 5-year recruitment...
Abstract Symptoms of mental illness can increase the risk disturbed behaviour. Joint intervention between police and health services is therefore sometimes needed to manage crisis events safely, divert people with a from further criminal justice system contact. This study explored how clinicians officers experience service interface identify perceived challenges tocollaboration possible solutions. was through circulation developed questionnaire staff Crisis Assessment Team Alfred Psychiatry...
Recent studies have proposed the existence of three distinct subgroups bipolar 1 disorder based on age at onset (AAO). The present study aims to investigate potential clinical and functional differences between these in an Australian sample.Participants (n = 239) were enrolled Bipolar Comprehensive Outcomes Study (BCOS), a 2-year longitudinal, observational, cross-sectional study. Assessment measures included Young Mania Rating Scale (YMRS), Hamilton Depression (HAMD21), Clinical Global...
Abstract Changes in brain volume are a common finding Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous longitudinal suggest that deficits progress illness duration. However, major unresolved question concerns whether these changes driven by the underlying or represent iatrogenic effects antipsychotic medication. Here, we report MRI findings from triple-blind randomised placebo-controlled study where 62 antipsychotic-naïve patients first episode (FEP) received...
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Abstract Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute dopaminergic dysfunction and symptom onset in psychosis, but it remains unclear whether this driven by aberrant bottom-up subcortical signaling or impaired top-down cortical regulation. Here, we used spectral dynamic causal modelling (DCM) resting-state functional magnetic resonance imaging (fMRI) characterize the effective connectivity dorsal ventral FST a sample 46 antipsychotic-naïve first-episode...
Abstract Background Altered functional connectivity (FC) is a common finding in resting-state Magnetic Resonance Imaging (rs-fMRI) studies of people with psychosis, yet how FC disturbances evolve the early stages illness, and antipsychotics may influence temporal evolution these disturbances, remains unclear. Here, we scanned first episode psychosis (FEP) patients who were not exposed to antipsychotic medication during six months illness at baseline, three months, 12 characterize changes...
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the 'Save PDF' action button.
Abstract Background Neuroimaging studies have found dysconnectivity of frontostriatal circuits across a broad spectrum psychotic symptoms. However, it is unknown whether within originates from disrupted bottom-up or top-down control signaling these systems. Here, we used dynamic causal modelling (DCM) to examine the effective connectivity systems in first-episode psychosis (FEP). Methods A total 55 FEP patients (26 males; mean [SD] age = 19.24 [2.89]) and 24 healthy controls (15 21.83...