A5015532195- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Treatment and Access
- Adolescent and Pediatric Healthcare
- Mental Health Research Topics
- Personality Disorders and Psychopathology
- Family Caregiving in Mental Illness
- Suicide and Self-Harm Studies
- Tryptophan and brain disorders
- Obsessive-Compulsive Spectrum Disorders
- Dysphagia Assessment and Management
- Mental Health and Psychiatry
- Functional Brain Connectivity Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Health disparities and outcomes
- Digital Mental Health Interventions
- Electroconvulsive Therapy Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Family and Disability Support Research
- Tracheal and airway disorders
- Treatment of Major Depression
- Mental Health and Patient Involvement
- Cannabis and Cannabinoid Research
- Family Support in Illness
The University of Melbourne
2016-2025
Orygen
2009-2025
Monash University
2015-2025
Park Centre for Mental Health
2025
Orygen Youth Health
2015-2024
Danetre Hospital
2024
Bristol Zoological Society
2024
Northamptonshire Healthcare NHS Foundation Trust
2021-2023
The Royal Melbourne Hospital
2023
University of Canberra
2020-2022
<h3>Context</h3> The use of antipsychotic medication for the prevention psychotic disorders is controversial. Long-chain ω-3 (omega-3) polyunsaturated fatty acids (PUFAs) may be beneficial in a range psychiatric conditions, including schizophrenia. Given that PUFAs are generally to health and without clinically relevant adverse effects, their preventive psychosis merits investigation. <h3>Objective</h3> To determine whether reduce rate progression first-episode disorder adolescents young...
The possible therapeutic impact of dietary changes on existing mental illness is largely unknown. Using a randomised controlled trial design, we aimed to investigate the efficacy improvement program for treatment major depressive episodes. 'SMILES' was 12-week, parallel-group, single blind, an adjunctive intervention in moderate severe depression. consisted seven individual nutritional consulting sessions delivered by clinical dietician. control condition comprised social support protocol...
Illness staging is widely utilized in several medical disciplines to help predict course or prognosis, and optimize treatment. Staging models psychiatry general, bipolar disorder particular, depend on the premise that psychopathology moves along a predictable path: an at-risk latency stage, prodrome progressing first clinical threshold episode, one more recurrences with potential revert progress late end-stage manifestations. The utility validity of model for its linking outcome, treatment...
The substantial individual heterogeneity that characterizes people with mental illness is often ignored by classical case-control research, which relies on group mean comparisons. Here we present a comprehensive, multiscale characterization of the gray matter volume (GMV) differences in 1,294 cases diagnosed one six conditions (attention-deficit/hyperactivity disorder, autism spectrum bipolar depression, obsessive-compulsive disorder and schizophrenia) 1,465 matched controls. Normative...
To determine the effects of gender on mental health literacy in young people between 12 and 25 years age.Computer-Assisted Telephone Interviewing was employed to conduct a cross-sectional structured interview focusing people's awareness depression psychosis.The sample comprised 1207 Australians (539 males 668 females) ages 12-25 recruited from two metropolitan regional areas within Victoria. Six hundred six respondents were presented vignette 601 psychosis vignette.Female (60.7%)...
Psychotic-like experiences (PLEs) increase the risk of schizophrenia and other psychotic disorders yet are common in community. Some PLEs, such as those associated with depression, distress, poor functioning, may confer increased risk. The aim this study is to determine prevalence PLEs a nonpsychotic clinical sample investigate whether any subtypes above factors. Consecutive referrals youth psychiatric service (N = 140) were assessed measure functioning. PLE data factor analyzed,...
Bechdolf A, Thompson Nelson B, Cotton S, Simmons MB, Amminger GP, Leicester Francey SM, McNab C, Krstev H, Sidis McGorry PD, Yung AR. Experience of trauma and conversion to psychosis in an ultra‐high‐risk (prodromal) group. Objective: We aimed replicate a recent finding high prevalence history patients at ‘ultra‐high risk’ (UHR) psychotic disorder investigate whether predicts this population. Method: A consecutive sample UHR was assessed. History accessed with the General Trauma...
Objectives: To assess young people's ability to recognise clinically defined depression and psychosis, the types of help they thought appropriate for these problems, their knowledge treatments, perceptions regarding prognosis. Design: A cross-sectional telephone survey using structured interviews. Vignettes a person with either or psychosis were presented, followed by questions related recognition disorder, best forms treatment Participants: randomly selected sample 1207 people aged 12–25...
Article Abstract Objective: Major depressive disorder (MDD) is one of the most common psychiatric disorders, conferring considerable individual, family, and community burden. To date, treatments for MDD have been derived from monoamine hypothesis, there a paucity emerging antidepressants, especially with novel mechanisms action treatment targets. N-acetylcysteine (NAC) redox-active glutathione precursor that decreases inflammatory cytokines, modulates glutamate, promotes neurogenesis,...
Objectives There are no established tools to identify individuals at risk for developing bipolar disorder. We developed a set of ultra‐high‐risk criteria disorder [bipolar at‐risk ( BAR )]. The primary aim the present study was determine predictive validity criteria. Methods This 12‐month prospective that conducted Orygen Youth Health Clinical Program, public mental health program young people aged 15–24 years in metropolitan Melbourne, Australia. At intake, screen‐positive and matched group...
Abstract Background Quality of life (QoL) is an important construct when assessing treatment outcomes. Aims To examine the relative contributions functioning, psychological well‐being and self‐efficacy on self‐perceived QoL with a sample total laryngectomy patients in Australia who had surgery for advanced laryngeal cancer. Methods & Procedures In cross‐sectional study, 113 members Laryngectomy Associations New South Wales Victoria, Australia, were recruited, each was sent series...
Abstract Lithium and quetiapine are effective treatments for bipolar disorder, but their potential neuroprotective effects in humans remain unclear. A single blinded equivalence randomized controlled maintenance trial was conducted a prospective cohort of first-episode mania (FEM) patients ( n =26) to longitudinally compare the putative protective lithium quetapine on grey white matter volume. healthy control sample also collected =20). Using structural MRI scans, voxel-wise volumes at...