A5081907162- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Treatment of Major Depression
- Natural Compound Pharmacology Studies
- Schizophrenia research and treatment
- Stress Responses and Cortisol
- Electrolyte and hormonal disorders
- Diet and metabolism studies
- Electroconvulsive Therapy Studies
- Personality Disorders and Psychopathology
- Mental Health Research Topics
- Biochemical Acid Research Studies
- Sleep and related disorders
- Medicinal Plant Extracts Effects
- Vitamin D Research Studies
- Gastrointestinal motility and disorders
- COVID-19 and Mental Health
- Child Abuse and Trauma
- Child and Adolescent Psychosocial and Emotional Development
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sleep and Wakefulness Research
- Posttraumatic Stress Disorder Research
- Ginkgo biloba and Cashew Applications
Barwon Health
2016-2025
Deakin University
2014-2025
Melbourne Clinic
2017-2020
The University of Melbourne
2017-2020
Florey Institute of Neuroscience and Mental Health
2016-2020
The Royal Melbourne Hospital
2018-2019
Orygen Youth Health
2017
Illness staging is widely utilized in several medical disciplines to help predict course or prognosis, and optimize treatment. Staging models psychiatry general, bipolar disorder particular, depend on the premise that psychopathology moves along a predictable path: an at-risk latency stage, prodrome progressing first clinical threshold episode, one more recurrences with potential revert progress late end-stage manifestations. The utility validity of model for its linking outcome, treatment...
Objective: Conventional antidepressant treatments result in symptom remission 30% of those treated for major depressive disorder, raising the need effective adjunctive therapies. Inflammation has an established role pathophysiology and minocycline been shown to modify immune-inflammatory processes also reduce oxidative stress promote neuronal growth. This double-blind, randomised, placebo-controlled trial examined (200 mg/day, addition treatment as usual) disorder. investigated 200 mg/day...
Abstract Objectives To understand treatment practices for bipolar disorders (BD), this study leveraged the Global Bipolar Cohort collaborative network to investigate pharmacotherapeutic patterns in multiple cohorts of well‐characterized individuals with BD North America, Europe, and Australia. Methods Data on pharmacotherapy, demographics, diagnostic subtypes, comorbidities were provided from each participating cohort. Individual site regional pooled proportional meta‐analyses generalized...
Abstract Background The depressive phase of bipolar disorder lasts longer than the manic and poses highest risk due to its negative impact on quality life mental health, peak in suicide attempts. Unfortunately, current therapies for are far more efficacious mania depression, suggesting an urgent need new improved depression. literature suggests chronic presence low-grade peripheral central inflammation is a key pathophysiology In particular, Angiotensin II Type I receptor (AT1R)...
ABSTRACT Introduction Post‐traumatic stress disorder (PTSD) is more prevalent in those with bipolar (BD) than the general population, rates of PTSD as high 55% some BD cohorts. Despite this, little research explores effects pharmacotherapy treatments comorbid and PTSD. This study aims to explore patterns use at baseline their impact on symptoms individuals alone Methods The Systematic Treatment Enhancement Program for (STEP‐BD) cohort was utilised examine compare between ( n = 3393) 304). We...
Background: Randomized controlled clinical trials that have investigated minocycline as an adjunctive treatment for major depressive disorder proved promising. Data from two studies were pooled to evaluate more definitively whether the addition of standard leads improvement symptoms when compared with placebo. Methods: Both multi-site, double-blinded, placebo-controlled 200 mg/day added usual during a 12-week period. The primary outcome measure was change in (Montgomery–Asberg Depression...
This study aimed to explore coping strategies, distress, and post-traumatic growth among Australians with without a history of mental health diagnosis during the COVID-19 pandemic.Australians (N = 381) completed an online survey between 4-August 2020 25-October-2020. Coping were ascertained via Brief COPE, Depression Anxiety Stress Scale (DASS-21), Post-Traumatic Growth Inventory (PTGI), respectively. Linear regression was conducted examine relationship DASS-21, PTGI, adjusting for...
We aimed to explore the relationships between diet quality, dietary inflammatory potential or body mass index and outcomes of a clinical trial nutraceutical treatment for bipolar depression.This is sub-study randomised controlled participants with depression who provided intake data (n = 133). Participants received 16 weeks adjunctive either placebo N-acetylcysteine-alone combination mitochondrial-enhancing nutraceuticals including N-acetylcysteine (combination treatment). were followed up 4...
Individuals with bipolar disorder (BD) generally engage in low levels of physical activity (PA), and yet few studies have investigated the relationship between PA change BD symptom severity. The aim this subanalysis an adjunctive nutraceutical randomized controlled trial for treatment depression was to explore PA, active treatments (a "mitochondrial cocktail"), clinical outcomes.Participants were receive N-acetylcysteine alone, a combination nutraceuticals (chosen potential increase...
Objectives: Garcinia mangostana Linn. (“mangosteen”) pericarp contains bioactive compounds that may target biological pathways implicated in schizophrenia. We conducted a double-blind randomized placebo-controlled trial evaluating the efficacy of adjunctive mangosteen pericarp, compared to placebo, treatment Methods: People diagnosed with schizophrenia or schizoaffective disorder ( Diagnostic and Statistical Manual Mental Disorders, Fifth Edition), recruited across 2 sites (Brisbane...
Gerard Anmella, Alcy Meehan, Melanie Ashton, Mohammadreza Mohebbi, Giovanna Fico, Chee H. Ng, Michael Maes, Lesley Berk, Michele De Prisco, Ajeet B. Singh, Gin S. Malhi, Seetal Dodd, Diego Hidalgo-Mazzei, Iria Grande, Isabella Pacchiarotti, Andrea Murru, Eduard Vieta, Olivia M. Dean. Clin Psychopharmacol Neurosci -0001;0:. https://doi.org/10.9758/cpn.23.1098
: Garcinia mangostana Linn., commonly known as mangosteen, is a tropical fruit with thick pericarp rind containing bioactive compounds that may be beneficial an adjunctive treatment for schizophrenia. The biological underpinnings of schizophrenia are believed to involve altered neurotransmission, inflammation, redox systems, mitochondrial dysfunction, and neurogenesis. Mangosteen contains xanthones which target these pathways improve symptoms; this supported by preclinical evidence. Here we...
This study aimed to explore effects of adjunctive minocycline treatment on inflammatory and neurogenesis markers in major depressive disorder (MDD). Serum samples were collected from a randomised, placebo-controlled 12-week clinical trial (200 mg/day, added as usual) for adults (n = 71) experiencing MDD determine changes interleukin-6 (IL-6), lipopolysaccharide binding protein (LBP) brain derived neurotrophic factor (BDNF). General Estimate Equation modelling explored moderation baseline...
Bipolar depression is characterized by neurobiological features including perturbed oxidative biology, reduction in antioxidant levels, and a concomitant rise stress markers. manifests systemic inflammation, mitochondrial dysfunction, changes brain growth factors. The depressive phase of the disorder most common responds least to conventional treatments. Garcinia mangostana Linn, commonly known as mangosteen, tropical fruit. pericarp's properties may reduce inflammation improve neurogenesis,...