A5101502541- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Genetic Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Mitochondrial Function and Pathology
- Intensive Care Unit Cognitive Disorders
- Diet and metabolism studies
- Anesthesia and Neurotoxicity Research
- Nuclear Receptors and Signaling
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- RNA modifications and cancer
- Autism Spectrum Disorder Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Amino Acid Enzymes and Metabolism
- Schizophrenia research and treatment
- Sulfur Compounds in Biology
- Cardiac, Anesthesia and Surgical Outcomes
- Bioinformatics and Genomic Networks
Deakin University
2016-2025
Florey Institute of Neuroscience and Mental Health
2009-2025
The University of Melbourne
2005-2025
University of Leicester
2024
Barwon Health
2020-2023
Faculty of Public Health
2014
Mental Health Research Institute
2005-2010
Duke-NUS Medical School
2009
Abstract Rett syndrome, commonly associated with mutations of the methyl CpG‐binding protein 2 ( MECP2 ) gene, is characterised by an apparently normal early postnatal development followed deterioration acquired cognitive and motor coordination skills in childhood. To evaluate whether environmental factors may influence disease outcome we tested effect enrichment from 4 weeks age on behavioural competence mutant mice harboring a Mecp2 tm1Tam ‐null allele. Our findings show that improves...
Huntington's disease (HD) is a neurodegenerative disorder, involving psychiatric, cognitive and motor symptoms, caused by CAG-repeat expansion encoding an extended polyglutamine tract in the huntingtin protein. Oxidative stress excitotoxicity have previously been implicated pathogenesis of HD. We hypothesized that N-acetylcysteine (NAC) may reduce both oxidative through its actions on glutamate reuptake antioxidant capacity. The R6/1 transgenic mouse model HD was used to investigate effects...
Abstract Baicalin is a flavone glycoside derived from flowering plants belonging to the Scutellaria genus. Previous studies have reported baicalin’s anti-inflammatory and neuroprotective properties in rodent models, indicating potential of baicalin neuropsychiatric disorders where alterations numerous processes are observed. However, extent therapeutic effects remains undetermined human cell model, more specifically, neuronal cells mimic brain environment vitro. As proof concept, we treated...
Abnormalities in glutamatergic signalling are proposed schizophrenia light of the schizophreniform psychosis elicited by NMDA antagonists. The metabotropic glutamate receptor 5 (mGluR5) interacts closely with and is implicated several behavioural endophenotypes schizophrenia. We have demonstrated that mice lacking mGluR5 increased sensitivity to hyperlocomotive effects antagonist MK-801. Mice also show abnormal locomotor patterns, reduced prepulse inhibition (PPI), deficits on performance a...
Focal adhesions and their dynamic nature are essential for various physiological processes, including the formation of neurites, synaptic function plasticity. Alterations in these processes have been associated with schizophrenia bipolar disorder. This study aimed to explore impact pharmacological treatments used disorder on expression genes involved focal adhesion pathway, addressing a gap understanding interaction between medication effects disease pathophysiology. NT2-N (neuron-like)...
To create a gene expression signature (GES) to represent the biological effects of combination known drugs for bipolar disorder (BD) on cultured human neuronal cells (NT2-N) and rat brains, which also has evidence differential in individuals with BD. use GES identify new BD using Connectivity Map (CMap).Methods: NT2-N (n = 20) rats 8) were treated drug (lithium, valproate, quetiapine lamotrigine) or vehicle 24 6 h, respectively. Following next-generation sequencing, genes was assessed edgeR...
The aim of this study was to repurpose a drug for the treatment bipolar depression.
Rett syndrome (RTT) is a neurodevelopmental disorder associated with mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2) and consequent dysregulation of brain maturation. Patients suffer from range debilitating physical symptoms, however, behavioral emotional symptoms also severely affect their quality life. Here, we present previously unreported clinically relevant affective dysfunction female heterozygous Mecp2(tm1Tam) mouse model RTT (129sv C57BL6 mixed...
Objective This study aimed to explore effects of adjunctive N -acetylcysteine (NAC) treatment on inflammatory and neurogenesis markers in unipolar depression. Methods We embarked a 12-week clinical trial NAC (2000 mg/day compared with placebo) as an for A follow-up visit was conducted 4 weeks following the completion treatment. collected serum samples at baseline end phase (week 12) determine changes interleukin-6 (IL6), C-reactive protein (CRP) brain-derived neurotrophic factor (BDNF)...
Altered protein synthesis has been implicated in the pathophysiology of several neuropsychiatric disorders, particularly schizophrenia. Ribosomes are machinery responsible for synthesis. However, there remains little information on whether current psychotropic drugs affect ribosomes and contribute to their therapeutic effects. We treated human neuronal-like (NT2-N) cells with amisulpride (10 µM), aripiprazole (0.1 clozapine lamotrigine (50 lithium (2.5 mM), quetiapine risperidone valproate...
Recent reports suggest a link between positive regulation of the Hippo pathway with bipolar disorder (BD), and is known to interact multiple other signaling pathways previously associated BD psychiatric disorders. In this study, neuronal-like NT2 cells were treated amisulpride (10 µM), aripiprazole (0.1 clozapine lamotrigine (50 lithium (2.5 mM), quetiapine risperidone valproate (0.5 or vehicle control for 24 h. Genome-wide mRNA expression was quantified analyzed using gene set enrichment...
Formaldehyde has a dramatic enhancing effect on not only the sensitivity but also selectivity of permanganate chemiluminescence detection towards thiol compounds, including glutathione – an important biomarker oxidative stress.
Bipolar disorder is a mental health condition with progressive social and cognitive function disturbances. Most patients' treatments are based on polypharmacy, but no biological basis little known of the drugs' interactions. The aim this study was to analyze effects lithium, valproate, quetiapine, lamotrigine, interactions between them, markers inflammation, bioenergetics, mitochondrial function, oxidative stress in neuron-like cells microglial cells.Neuron-like lipopolysaccharide-stimulated...
Abstract Objective This study aimed to explore effects of adjunctive treatment with N -acetyl cysteine (NAC) on markers inflammation and neurogenesis in bipolar depression. Methods is a secondary analysis placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, 32 the open-label maintenance phases clinical trial determine changes interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-α (TNF-α), C-reactive protein (CRP) brain-derived neurotrophic factor (BDNF)...
Background: The drugs commonly used to treat bipolar disorder have limited efficacy and drug discovery is hampered by the paucity of knowledge pathophysiology this disease. This study aims explore role microRNAs in understand molecular mechanisms action drugs. Methods: transcriptional effects combination (lithium, valproate, lamotrigine quetiapine) cultured human neuronal cells were studied using next generation sequencing. Differential expression genes ( n=20) n=6) was assessed...