A5090073956- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Schizophrenia research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Ion channel regulation and function
- Bipolar Disorder and Treatment
- Neuropeptides and Animal Physiology
- Diet and metabolism studies
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Effects and Toxicity Studies
- Genetics and Neurodevelopmental Disorders
- Drug Transport and Resistance Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Treatment of Major Depression
- Genetic Associations and Epidemiology
- Epilepsy research and treatment
- Analytical Chemistry and Chromatography
- Pharmacogenetics and Drug Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Neuroendocrine regulation and behavior
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Biosimilars and Bioanalytical Methods
Florey Institute of Neuroscience and Mental Health
2015-2024
The University of Melbourne
2014-2024
Swinburne University of Technology
2017-2024
Sunesis (United States)
2016-2023
Mental Health Australia
2016-2022
Cooperative Research Centre for Mental Health
2015-2020
Monash University
2003-2019
Monash Health
2001-2019
Centre for Mental Health
2019
Virginia Commonwealth University
2018
Human altruism is a widespread phenomenon that puzzled evolutionary biologists since Darwin. Economic games illustrate human by showing behavior deviates from economic predictions of profit maximization. A game most plainly shows this altruistic tendency the Dictator Game. We hypothesized to some extent hardwired and likely candidate may contribute individual differences in arginine vasopressin 1a ( AVPR1a ) receptor mammals such as vole has profound impact on affiliative behaviors. In...
Major depressive disorder is associated with an increased risk of mortality and aging-related diseases. The authors examined whether major depression higher epigenetic aging in blood as measured by DNA methylation (DNAm) patterns, clinical characteristics have a further impact on these the findings replicate brain tissue.DNAm age was estimated using all sites 811 depressed patients 319 control subjects no lifetime psychiatric disorders low symptoms from Netherlands Study Depression Anxiety....
Autophagy is a process preserving the balance between synthesis, degradation and recycling of cellular components therefore essential for neuronal survival function. Several key proteins govern autophagy pathway including beclin1 microtubule associated protein 1 light chain 3 (LC3). Here, we show brain-specific reduction in expression postmortem hippocampus schizophrenia patients, not detected peripheral lymphocytes. This contrast with activity-dependent neuroprotective (ADNP) ADNP2, which...
Multiple quantifiable biologic abnormalities have been localized to the hippocampus in schizophrenia. Alterations glutamate-mediated transmission at N-methyl-D-aspartic acid (NMDA)-sensitive receptors implicated pathophysiology of illness. The authors tested hypothesis that glutamatergic within and efferent from is altered schizophrenia.The analyzed postmortem hippocampal tissue individuals with schizophrenia healthy individuals. samples had collected by two brain banks, one Maryland other...
OBJECTIVE: Aberrant cholinergic inputs and synaptic neurotransmission in the prefrontal cortex induce cognitive impairment, which is a central feature of schizophrenia. Postsynaptic excitatory muscarinic M1 M4 receptors are major cholinoceptive targets hence may be involved pathology and/or pharmacotherapeutics METHOD: Using quantitative autoradiography, authors analyzed binding M1/M4 receptor selective antagonist [3H]pirenzepine (Brodmann's areas 8, 9, 10, 46) from schizophrenia patients...
Acid-reducing agents (ARAs) are the most commonly prescribed medications in North America and Western Europe. There currently no data describing prevalence of their use among cancer patients. However, this is a paramount question due to potential for significant drug–drug interactions (DDIs) between ARAs, proton pump inhibitors (PPIs), orally administered therapeutics that display pH-dependent solubility, which may lead decreased drug absorption therapeutic benefit. Of recently approved...
We performed integrated gene coexpression network analysis on two large microarray-based brain expression data sets generated from the prefrontal cortex obtained post-mortem 101 subjects, 47 subjects with schizophrenia and 54 normal control ranging in age 19 to 81 years. Twenty-eight modules of coexpressed genes functional interpretations were detected both those schizophrenia. Significant overlap “case” “control” module composition was observed, indicating that extensive differences...
Increasing evidence suggests that epigenetic factors have critical roles in gene regulation neuropsychiatric disorders and aging, both of which are typically associated with a wide range expression abnormalities. Here, we used chromatin immunoprecipitation-qPCR to measure levels acetylated histone H3 at lysines 9/14 (ac-H3K9K14), two marks transcriptionally active chromatin, the promoter regions eight schizophrenia-related genes n=82 postmortem prefrontal cortical samples from normal...
Lysosomal storage diseases (LSDs) are a group of heterogeneous disorders caused by defects in lysosomal enzymes or transporters, resulting accumulation undegraded macromolecules metabolites. Macrophage numbers expanded several LSDs, leading to histiocytosis unknown pathophysiology. Here, we found that mice lacking the equilibrative nucleoside transporter 3 (ENT3) developed spontaneous and progressive macrophage-dominated histiocytosis. In absence ENT3, defective apoptotic cell clearance led...
Acetylcholine has been implicated in both the pathophysiology and treatment of a number psychiatric disorders, with most data related to its role therapeutic potential focusing on schizophrenia. However, there is little thought given consequences documented changes cholinergic system how they may affect functioning brain. This review looks at interactions intrinsic neurotransmitters glutamate gamma-amino butyric acid as well those projection pathophysiologies disorders; dopamine serotonin....
Abstract Given the complexity and heterogeneity of genomic architecture underlying schizophrenia, molecular analyses these patients with defined large effect-size defects could provide valuable clues. We established human-induced pluripotent stem cells from two schizophrenia 22q11.2 deletion (two cell lines each subject, total four lines) three controls (total lines). Neurosphere size, neural differentiation efficiency, neurite outgrowth, cellular migration neurogenic-to-gliogenic competence...
Identification and characterisation of novel targets for treatment is a priority in the field psychiatry. FKBP5 gene with decades evidence suggesting its pathogenic role subset psychiatric patients, potential to be leveraged as therapeutic target these individuals. While it widely reported that FKBP5/FKBP51 mRNA/protein (FKBP5/1) expression impacted by disease state, risk genotype age, not known which cell types sub-anatomical areas human brain this occurs. This knowledge critical propel...