A5100632713- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Immune Response and Inflammation
- Neuroendocrine Tumor Research Advances
- Cancer therapeutics and mechanisms
- Hip and Femur Fractures
- Tuberculosis Research and Epidemiology
- Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Network Time Synchronization Technologies
- Energy Efficient Wireless Sensor Networks
- Cardiac, Anesthesia and Surgical Outcomes
- Brain Metastases and Treatment
- Dermatologic Treatments and Research
- Oral and gingival health research
- Adenosine and Purinergic Signaling
- Fermentation and Sensory Analysis
- RNA Research and Splicing
- Frailty in Older Adults
- Cancer Mechanisms and Therapy
Zhejiang Cancer Hospital
2014-2024
Chinese Academy of Sciences
2011-2024
University of Chinese Academy of Sciences
2020-2023
Zhejiang Chinese Medical University
2023
Cancer Hospital of Chinese Academy of Medical Sciences
2020-2022
Roche (United States)
2021
The First Affiliated Hospital, Sun Yat-sen University
2016-2017
Sun Yat-sen University
2016-2017
Yunnan University
2016
Institute of Software
2011
Lysosomal storage diseases (LSDs) are a group of heterogeneous disorders caused by defects in lysosomal enzymes or transporters, resulting accumulation undegraded macromolecules metabolites. Macrophage numbers expanded several LSDs, leading to histiocytosis unknown pathophysiology. Here, we found that mice lacking the equilibrative nucleoside transporter 3 (ENT3) developed spontaneous and progressive macrophage-dominated histiocytosis. In absence ENT3, defective apoptotic cell clearance led...
Transforming growth factor-β (TGFβ) is a key driver of fibrogenesis. Three TGFβ isoforms (TGFβ1, TGFβ2, and TGFβ3) in mammals have distinct functions embryonic development; however, the postnatal pathological roles activation mechanisms TGFβ2 TGFβ3 not been well characterized. Here, we show that latent forms can be activated by integrin-independent lower thresholds compared to TGFβ1. Unlike TGFB1, TGFB2 TGFB3 expression increased human lung liver fibrotic tissues healthy control tissues....
In the present study, we observed expression of toll-like receptor 4 (TLR4) and its downstream signal pathway in peripheral blood monocytes (PBMs) from patients with acute cerebral infarct (ACI). The TLR4 MyD88 by PBMs was determined flow cytometry reverse transcriptase-polymerase chain reaction, nuclear factor-κB (NF-κB) activity detected electrophoretic mobility shift assay. Ischemia/reperfusion injury-induced edema, infarction area, neurologic impairment scores were gene knockout mice....
BackgroundTransforming growth factor β (TGF-β) is implicated as a key mediator of pathological fibrosis, but its pleiotropic activity in range homeostatic functions presents challenges to safe and effective therapeutic targeting. There are three isoforms TGF-β, TGF-β1, TGF-β2, TGF-β3, which bind common receptor complex composed TGF-βR1 TGF-βR2 induce similar intracellular signals vitro. We have recently shown that the cellular expression patterns activation thresholds TGF-β2 TGF-β3 distinct...
Endophytes proved to exert multiple effects on host plants, including growth promotion, stress resistance. However, whether endophytes have a role in metabolites shaping of grape has not been fully understood. Eight endophytic fungal strains which originally isolated from grapevines were re-inoculated field-grown this study, and their both leaves berries at maturity stage assessed, with special focused secondary antioxidant activities. High-density inoculation all these modified the...
According to the latest World Health Organization (WHO) classification in 2015, invasive mucinous adenocarcinoma (IMA) is defined as a new pathological subtype of lung (LUAD). However, whether this rare pathology has any difference prognosis than conventional LUAD debatable. Our study attempted compare clinical characteristics and IMA vs. noninvasive adenocarcinomas (NMA).A total 1,857 patients with who underwent radical resection were screened from 2010 2015 at Zhejiang Cancer Hospital....
Inhibiting the kinase IRAK4 may suppress a multicellular autoinflammatory loop in patients with lupus.
Previous small-size studies reported BRAF-mutated NSCLC patients have comparable sensitivity to immune checkpoint inhibitors (ICIs). However, how BRAF mutation affects the tumor microenvironment (TIME) is unknown. We performed Nanostring-panel RNA sequencing evaluate TIME in 57 mutated and wild-type (WT) specimens (cohort A). The efficacy of ICI monotherapy or combined therapies was determined 417 with WT B). found that BRAF-mutant tumors had similar ratios CD8+ T cells Tregs, balance...
Abstract Bone morphogenetic protein 1 (BMP1) belongs to the astacin/BMP1/tolloid-like family of zinc metalloproteinases, which play a fundamental role in development and formation extracellular matrix (ECM). BMP1 mediates cleavage carboxyl terminal (C-term) propeptides from procollagens, crucial step fibrillar collagen fiber formation. Blocking by small molecule or antibody inhibitors has been linked anti-fibrotic activity preclinical models skin, kidney liver fibrosis. Therefore, we reason...
Abstract Background Determining the tissue of origin (TOO) is essential for managing cancer unknown primary (CUP). In this study, we evaluated concordance between genome profiling and DNA methylation analysis in determining TOO lung-specific CUP assessed their performance by comparing clinical responses survival outcomes patients predicted with multiple or metastatic cancer. Methods We started retrospectively screening who presented both intra- extrathoracic tumors. Tumor samples from...
Second-line treatment options for small cell lung cancer (SCLC) are limited. Preclinical research shows that inhibition of poly (ADP-ribose) polymerase (PARP) could upregulate programmed death-ligand 1 (PD-L1), and thus render cells more sensitive to immune checkpoint inhibitors. This study investigated the tolerability, safety, preliminary antitumor activity fuzuloparib (a PARP inhibitor) plus SHR-1316 PD-L1 relapsed SCLC.Patients with SCLC who failed previous first-line platinum-based...
Multi-hop time synchronization in wireless sensor networks (WSNs) is often time-consuming and error-prone due to random time-stamp delays for MAC layer access unstable clocks of intermediate nodes. Constructive interference (CI), a recently discovered physical phenomenon, allows multiple nodes transmit forward an identical packet simultaneously. By leveraging CI, we propose direct multi-hop (DMH) by directly utilizing the time-stamps from sink node instead nodes, which avoids error caused...
Purpose: To compare the postoperative survival and mortality rates in intertrochanteric femoral fracture (IFF) patients who underwent either open reduction internal fixation (ORIF) or hip arthroplasty. Methods: Clinical data from senior had IFF ORIF arthroplasty were analyzed retrospectively. Survival curves compared between groups with Kaplan–Meier method log-rank test. Significant independent prognostic factors identified by Cox multivariate regression analysis. Results: All recovered...
To evaluate the long-term safety and efficacy of atezolizumab monotherapy in Chinese patients with previously treated, locally advanced or metastatic non-small cell lung cancer (NSCLC).In this open-label, single-arm, multicenter study, received 1200 mg intravenously on Day 1 each 21-day cycle. The primary endpoint was incidence atezolizumab-related serious adverse events (SAEs). Secondary endpoints included other measures. Patients available tumor tissue blood samples underwent biomarker...
Background: Programmed cell death-ligand-1 (PD-L1) has been highly up-regulated in various malignancies. The present study was intended to explore the frequency of PD-L1 expression and understand its role as a prognostic factor for overall survival primary small carcinoma esophagus (SCCE).
The aim was to investigate the association between uridine diphosphate glucuronide transferase 1A1 (UGT1A1) gene promoter region polymorphism and irinotecan-related adverse effects efficacy on recurrent refractory small cell lung cancer (SCLC).A total of 31 patients with SCLC were enrolled in this study from June 2012 August 2013 received at least two cycles single-agent irinotecan chemotherapy. evaluated. DNA extracted peripheral blood direct sequencing method employed test UGT1A1FNx0128...
The coverability of Wireless Sensor Networks (WSNs) is essentially a Quality Service (QoS) problem that measures how well the monitored area covered by one or more sensor nodes. cover-ability WSNs was examined combining existing computational geometry techniques such as Voronoi diagram and Delaunay triangulation with graph theoretical algorithmic techniques. Three new evaluation algorithms, known CRM (Comprehensive Risk Minimization), TWS (Threshold Weight Shortest path), CSM Support...
Abstract The IRAK4 kinase is a key regulator of TLR and IL1R signaling. Small molecule inhibitors represent an important advance in targeting these pathways. We developed high throughput whole blood assay to identify potent through the inhibition ligand (R848, LPS, Gardiquimod) induced inflammatory cytokine production (IL6, TNF, IFNa). Extensive optimization was carried out ensure rigorous measurement small potencies, percent maximum inhibition, endpoint correlations clearly distinguish...