A5101643914- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Cancer-related molecular mechanisms research
- Membrane Separation Technologies
- Mesenchymal stem cell research
- Knee injuries and reconstruction techniques
- Orthopaedic implants and arthroplasty
- Surface Modification and Superhydrophobicity
- Orthopedic Infections and Treatments
- Blood transfusion and management
- Circular RNAs in diseases
- Lower Extremity Biomechanics and Pathologies
- Proteoglycans and glycosaminoglycans research
- Membrane Separation and Gas Transport
- MicroRNA in disease regulation
- Platelet Disorders and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Silk-based biomaterials and applications
- Cardiac, Anesthesia and Surgical Outcomes
- Hip and Femur Fractures
- Hip disorders and treatments
- Venous Thromboembolism Diagnosis and Management
- RNA modifications and cancer
- Frailty in Older Adults
- Nanomaterials and Printing Technologies
Sun Yat-sen University
2014-2024
The First Affiliated Hospital, Sun Yat-sen University
2013-2024
Tiangong University
2023-2024
Baylor Scott & White Medical Center - Temple
2024
Taipei Tzu Chi Hospital
2023
Bristol-Myers Squibb (United States)
2023
Key Laboratory of Guangdong Province
2021
Hangzhou Normal University
2021
Weatherford College
2020
Metalloproteinases (MMPs) are key regulators of osteoarthritis (OA) and collagen degradation have been shown to participate in endochondral ossification. The aim this study was determine whether microRNA-320 (miR-320) regulates the expression MMP-13 chondrogenesis inflammation.miR-320 assessed vitro, ATDC5 cell model interleukin-1β (IL-1β)-treated primary mouse chondrocytes (PMCs), vivo, normal OA human cartilage by situ hybridization. PMCs were transfected with miR-320 or its antisense...
Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-specific gene expression human chondrocytes. The aim this study was to determine whether microRNA-193b-3p (miR-193b-3p) regulates HDAC3 during chondrogenesis and chondrocyte metabolism. Methods: miR-193b-3p assessed mesenchymal stem cell (hMSC) model chondrogenesis, interleukin-1β (IL-1β)-treated primary chondrocytes (PHCs), non-degraded degraded cartilage. hMSCs PHCs were transfected with or its antisense...
Abstract The development of low‐pressure or pressureless self‐driven membranes is important for saving energy and overcoming the critical trade‐off effect in membrane separation processes. However, conventional rely on gravity, which effective large‐sized materials but still ineffective fine small molecules. Herein, inspired by capillary that exists nature, a force‐induced membrane‐driving strategy at ultra‐low pressures demonstrated. Hydrophilic nanoparticles are prepared cross‐linking...
Abstract Human adipose‐derived stem cells (hADSC) are capable of differentiating into an osteogenic lineage. It is believed that microRNAs (miRNAs) play important roles in regulating this differentiation human cells, although its molecular mechanism remains unclear. We investigated the miRNA expression profile during hADSCs, and assessed involved miRNAs differentiation. obtained cultured stems from donors who underwent elective liposuction or other abdominal surgery at our institution....
Cartilage generation and degradation are regulated by miRNAs. Our previous study has shown altered expression of miR‐193b in chondrogenic human adipose‐derived mesenchymal stem cells (hADSCs). In the current study, we investigated role chondrogenesis cartilage degradation. Luciferase reporter assays showed that targeted seed sequences TGFB2 TGFBR3 3′‐UTRs. MiR‐193b suppressed early markers ATDC5 cells, TNF‐alpha IL‐1b‐induced PMCs. conclusion, may inhibit targeting TGFBR3, regulate...
Abstract Micro(mi)RNAs are small, non‐coding RNA molecules known to play a significant role in osteoarthritis (OA) initiation and development, similar matrix metalloproteinases (MMPs), they participate cartilage degeneration cleave multiple extracellular matrices. The aim of this study was determine whether the expression MMP‐19 interleukin (IL)‐1β‐induced human chondrocytes is directly regulated by miR‐193b‐3p. Expression levels miR‐193b‐3p normal cartilage, interleukin‐1 β (IL‐1β)‐induced...
Application of chondrogenic growth factors is a routine strategy to induce chondrogenesis hMSCs, but they have economic and safety problems in the long term. It expected that scaffold material itself could play an important role hMSCs. In this study we tested whether novel tricalcium phosphate-collagen-hyaluronan (TCP-COL-HA) had inherent chondro-inductive capacity for both ATDC5 hMSCs without any exogenous vitro. were seeded onto TCP-COL-HA scaffolds cultured basal medium 3 weeks...
tRNA-derived fragments (tRFs) are new noncoding RNAs, and recent studies have shown that tRNAs tRFs important functions in cell metabolism via posttranscriptional regulation of gene expression. However, whether regulate cellular the anterior cruciate ligament (ACL) remains elusive. The aim this study was to investigate role action mechanism ACL metabolism. A tRF array used determine expression profiles different human cells, quantitative real-time polymerase chain reaction fluorescence situ...
Purpose: To compare the postoperative survival and mortality rates in intertrochanteric femoral fracture (IFF) patients who underwent either open reduction internal fixation (ORIF) or hip arthroplasty. Methods: Clinical data from senior had IFF ORIF arthroplasty were analyzed retrospectively. Survival curves compared between groups with Kaplan–Meier method log-rank test. Significant independent prognostic factors identified by Cox multivariate regression analysis. Results: All recovered...
Abstract Background The meniscus plays a vital role in the normal biomechanics of knee. However, it is not well studied at molecular level. purpose this study was to determine whether and pathological changes meniscal tissue vary depending on presence or absence and/or anterior cruciate ligament tear (ACL). Methods Six menisci (group A), seven simple torn B) with concomitant tears C) were collected. We observed used real-time polymerase chain reaction along immunohistochemistry situ...
Comparison of different anticoagulants in blood management and complications with tranexamic acid (TXA) total hip arthroplasty (THA) is unclear. Our aim was to compare the efficacy safety among receiving nadroparin calcium, enoxaparin sodium or rivaroxaban after TXA THA.150 patients undergoing primary unilateral THA were received 15 mg/kg intravenous (IV-TXA) before skin incision, followed by 1 calcium (Group A), B), C) randomly during hospitalization. The outcome hidden loss (HBL). Other...
Hyaluronan (HA) provides a favorable environment for chondrogenesis of bone marrow mesenchymal stem cells (BMSCs). A previous report from our group indicated that addition HA increases the chondro-inductive capacity scaffolds. Therefore, this study aimed to investigate whether Mw could affect BMSCs seeded on TCP-COL-HA Human (hBMSCs) and rabbit (rBMSCs) were isolated expanded. TCP-COL scaffolds with two different Mws assessed their induce cartilage regeneration hBMSCs in vitro vivo. The...
Abstract Purpose We describe a surgical technique for ACL reconstruction combined with anterolateral structure reinforcement and report early clinical follow-up results. Methods The semitendinosus gracilis tendons are braided into 5 strands the femoral tunnel tibial created. graft is passed through use of traction suture end fixed absorbable interference screws at 30° knee flexion. used as an to pass proximal exit then depth iliotibial bundle anterior Gerdy’s tubercle, bony created from...
The influence of the graft sagittal inclination angle (SIA) on knee stability, biomechanics, and maturity has been elucidated. However, no study comprehensively described effects SIA aforementioned postoperative prognostic indicators. So, we aimed to determine whether a is associated with maturity, joint function after anterior cruciate ligament (ACL) reconstruction. Patients who had undergone ACL reconstruction between April 2019 February 2022 those intact were eligible. Using magnetic...