A5053779997- Parasites and Host Interactions
- Drug-Induced Hepatotoxicity and Protection
- Parasite Biology and Host Interactions
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Influenza Virus Research Studies
- Respiratory viral infections research
- Liver physiology and pathology
- Bacteriophages and microbial interactions
- Helminth infection and control
- Hepatitis B Virus Studies
- Probiotics and Fermented Foods
- Liver Disease and Transplantation
- Parasitic Diseases Research and Treatment
- Gut microbiota and health
- Digestive system and related health
- Tuberculosis Research and Epidemiology
- Animal Disease Management and Epidemiology
- Antimicrobial Peptides and Activities
- Folate and B Vitamins Research
- Pneumonia and Respiratory Infections
- Biological Research and Disease Studies
- Analytical chemistry methods development
- Neonatal and Maternal Infections
- Animal Nutrition and Physiology
Nanjing University of Chinese Medicine
2025
Sun Yat-sen University
2014-2024
Third Affiliated Hospital of Sun Yat-sen University
2020-2024
Shengli Oilfield Central Hospital
2024
Weatherford College
2024
World Health Organization
2023
University of Illinois Chicago
2017-2020
Yuxi Normal University
2019
Epidemic Intelligence Service
2018
National Center for Immunization and Respiratory Diseases
2018
Influenza-associated deaths in children occur annually. We describe the epidemiology of influenza-associated pediatric from 2004-2005 through 2011-2012 influenza seasons.Deaths <18 years age with laboratory-confirmed virus infection were reported to Centers for Disease Control and Prevention by using a standard case report form collect data on demographic characteristics, medical conditions, clinical course, laboratory results. Characteristics no high-risk conditions compared those...
In this case-control study of 89 subjects infected with novel avian influenza A(H7N9) and 340 age- sex-matched controls, visiting live bird markets having poultry contact were independent risk factors for virus infection. Background. The majority human cases A(H7N9), which emerged in China spring 2013, include reported exposure to poultry. However, specific host disease are unknown, yet critical design prevention measures. Methods. April–June we conducted a 8 Chinese provinces. Patients...
Clonorchiasis caused by Clonorchis sinensis has become increasingly prevalent in recent years. Effective prevention strategies are urgently needed to control this food-borne infectious disease. Previous studies indicated that paramyosin of C. (CsPmy) is a potential vaccine candidate. We constructed recombinant plasmid PEB03-CotC-CsPmy, transformed it into Bacillus subtilis WB600 strain (B.s-CotC-CsPmy), and confirmed CsPmy expression on the spore surface SDS-PAGE, Western blotting...
Abstract Background Probiotic lactic acid bacteria (LAB) have been used in the anti-inflammation and anti-infection process of various diseases, including inflammatory bowel disease (IBD). Vitamin D receptor (VDR) plays an essential role pathogenesis IBD infectious diseases. Previous studies demonstrated that human VDR gene is a key host factor to shape gut microbiome. Furthermore, intestinal epithelial conditional knockout (VDRΔIEC) leads dysbiosis. Low expressions associated with impaired...
Long-term infections by Clonorchis sinensis are associated with cholangitis, cholecystitis, liver fibrosis, cirrhosis, and even cancer. Molecules from the worm play vital roles in disease progress. In present study, we identified explored molecular characterization of C. granulin (CsGRN), a growth factor-like protein excretory/secretory products (CsESPs). The encoding sequence conserved domains CsGRN were analysed bioinformatics tools. Recombinant (rCsGRN) was expressed Escherichia coli BL21...
Background The HuoXueTongFu Formula (HXTF) originates from the classic prescription “ DaHuangMuDan Decoction” “Synopsis of golden chamber”. Our previous study revealed that HXTF has a positive effect on postoperative peritoneal adhesion (PPA). However, specific mechanism PPA formation within time-to-treatment window not been fully elucidated. This aimed to determine critical roles as result its anti-inflammatory and antifibrinolytic activities for treatment. Methods eight main bioactive...
Clonorchiasis, a food-borne zoonosis, is caused by Clonorchis sinensis. The intestinal tract and bile ducts are crucial places for C. sinensis metacercariae to develop into adult worms. endospore of Bacillus subtilis an ideal oral immunization vehicle delivery heterologous antigens intestine. Cysteine protease (CsCP) endogenous key component in the excystment other physiological or pathological processes.We constructed fusion gene CotC (a coat protein)-CsCP obtained B. spores with...
Clonorchis sinensis (C. sinensis) is the most widespread human liver fluke in East Asia including China and Korea. Clonorchiasis as a neglected tropical zoonosis, leads to serious economic public health burden China. There are considerable evidences for an etiological relation between chronic clonorchiasis fibrosis beings. Liver highly conserved over-protected response hepatic tissue injury. Immune cells CD4+ T cell well dendritic (DC), pro-fibrogenic cytokines like interleukin 4 (IL-4),...
Background In vitro fertilization (IVF) researches have suggested that cystathionine β synthase (CBS) is involved in oocyte development. However, little known about the regional and cellular expression patterns of CBS ovary. The purpose this study was to analyze localization mice ovaries investigate profile during follicular Methods We used situ hybridization immunohistochemical analysis determine female Balb/c mice. Then follicles were collected from F1 (C57BL×Balb/c) cultured vitro. With...
Clonorchiasis, caused by chronic infection with Clonorchis sinensis (C. sinensis), is an important food-borne parasitic disease that seriously afflicts more than 35 million people globally, resulting in a socioeconomic burden endemic regions. C. adults long-term inhabit the microaerobic and limited-glucose environment of bile ducts. Energy metabolism plays key role facilitating adaptation adult flukes to crowded habitat hostile environment. To understand energy source for flukes, we compared...
Clonorchiasis, which is induced by the infection of Clonorchis sinensis (C. sinensis), highly associated with cholangiocarcinoma. Because available examination, treatment and interrupting transmission provide limited opportunities to prevent infection, it urgent develop integrated strategies control clonorchiasis. Glycolytic enzymes are crucial molecules for trematode survival have been targeted drug development. Hexokinase C. (CsHK), first key regulatory enzyme glycolytic pathway, was...
Numerous experimental and epidemiological studies have demonstrated a link between Clonorchis sinensis (C. sinensis) infestation cholangiocarcinoma (CCA) as well hepatocellular carcinoma (HCC). The underlying molecular mechanism involved in the malignancy of CCA HCC has not yet been addressed. Csseverin, component excretory/secretory products C. (CsESPs), was confirmed to cause obvious apoptotic inhibition human cell line PLC. However, antiapoptotic is unclear. In present study, we...
In China, people infected with hepatitis B virus (HBV) are commonly found in areas a high prevalence of Clonorchis sinensis, trematode worm. Published studies have reported that the progression is affected by coinfection C. sinensis.Clinical data from total 72 patients sinensis and HBV (as sole infection or coinfections) 29 healthy individuals were analysed. We also incubated hepatic stellate cell line LX-2 proteins adult worms (CsTPs) HBV-positive sera. addition, human hepatoblastoma...
Secreted phospholipase A2 (sPLA2) is a protein secreted by Clonorchis sinensis and component of excretory secretory products (CsESPs). Phospholipase well known for its role in liver fibrosis inhibition tumour cells. The JNK signalling pathway involved hepatic stellate cells (HSCs) activation. Blocking activity with SP600125 inhibits HSCs In previous study, the CssPLA2 was expressed insoluble inclusion bodies. Therefore, it's necessary to express water-soluble form determine whether enzymatic...